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Alveoli increase in number but not size from birth to adulthood in rhesus monkeys.
Am J Physiol Lung Cell Mol Physiol. 2007 Sep; 293(3):L570-9.AJ

Abstract

Postnatal developmental stages of lung parenchyma in rhesus monkeys is about one-third that of humans. Alveoli in humans are reported to be formed up to 8 yr of age. We used design-based stereological methods to estimate the number of alveoli (N(alv)) in male and female rhesus monkeys over the first 7 yr of life. Twenty-six rhesus monkeys (13 males ranging in age from 4 to 1,920 days and lung volumes from 41.7 to 602 cm(3), 13 females ranging in age from 22 to 2,675 days and lung volumes from 43.5 to 380 cm(3)) were necropsied and lungs fixed, isotropically oriented, fractionated, sampled, embedded, and sectioned for alveolar counting. Parenchymal, alveolar, alveolar duct core air, and interalveolar septal tissue volumes increased rapidly during the first 2 yr with slowed growth from 2 to 7 yr. The rate of change was greater in males than females. N(alv) also showed consistent growth throughout the study, with increases in N(alv) best predicted by increases in lung volume. However, mean alveolar volume showed little relationship with age, lung volume, or body weight but was larger in females and showed a greater size distribution than in males. Alveoli increase in number but not volume throughout postnatal development in rhesus monkeys.

Authors+Show Affiliations

California National Primate Research Center, One Shields Ave., University of California, Davis, Davis, CA 95616, USA. dmhyde@primate.ucdavis.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

17586691

Citation

Hyde, Dallas M., et al. "Alveoli Increase in Number but Not Size From Birth to Adulthood in Rhesus Monkeys." American Journal of Physiology. Lung Cellular and Molecular Physiology, vol. 293, no. 3, 2007, pp. L570-9.
Hyde DM, Blozis SA, Avdalovic MV, et al. Alveoli increase in number but not size from birth to adulthood in rhesus monkeys. Am J Physiol Lung Cell Mol Physiol. 2007;293(3):L570-9.
Hyde, D. M., Blozis, S. A., Avdalovic, M. V., Putney, L. F., Dettorre, R., Quesenberry, N. J., Singh, P., & Tyler, N. K. (2007). Alveoli increase in number but not size from birth to adulthood in rhesus monkeys. American Journal of Physiology. Lung Cellular and Molecular Physiology, 293(3), L570-9.
Hyde DM, et al. Alveoli Increase in Number but Not Size From Birth to Adulthood in Rhesus Monkeys. Am J Physiol Lung Cell Mol Physiol. 2007;293(3):L570-9. PubMed PMID: 17586691.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Alveoli increase in number but not size from birth to adulthood in rhesus monkeys. AU - Hyde,Dallas M, AU - Blozis,Shelley A, AU - Avdalovic,Mark V, AU - Putney,Lei F, AU - Dettorre,Rachel, AU - Quesenberry,Nathanial J, AU - Singh,Paramjit, AU - Tyler,Nancy K, Y1 - 2007/06/22/ PY - 2007/6/26/pubmed PY - 2007/10/18/medline PY - 2007/6/26/entrez SP - L570 EP - 9 JF - American journal of physiology. Lung cellular and molecular physiology JO - Am J Physiol Lung Cell Mol Physiol VL - 293 IS - 3 N2 - Postnatal developmental stages of lung parenchyma in rhesus monkeys is about one-third that of humans. Alveoli in humans are reported to be formed up to 8 yr of age. We used design-based stereological methods to estimate the number of alveoli (N(alv)) in male and female rhesus monkeys over the first 7 yr of life. Twenty-six rhesus monkeys (13 males ranging in age from 4 to 1,920 days and lung volumes from 41.7 to 602 cm(3), 13 females ranging in age from 22 to 2,675 days and lung volumes from 43.5 to 380 cm(3)) were necropsied and lungs fixed, isotropically oriented, fractionated, sampled, embedded, and sectioned for alveolar counting. Parenchymal, alveolar, alveolar duct core air, and interalveolar septal tissue volumes increased rapidly during the first 2 yr with slowed growth from 2 to 7 yr. The rate of change was greater in males than females. N(alv) also showed consistent growth throughout the study, with increases in N(alv) best predicted by increases in lung volume. However, mean alveolar volume showed little relationship with age, lung volume, or body weight but was larger in females and showed a greater size distribution than in males. Alveoli increase in number but not volume throughout postnatal development in rhesus monkeys. SN - 1040-0605 UR - https://www.unboundmedicine.com/medline/citation/17586691/Alveoli_increase_in_number_but_not_size_from_birth_to_adulthood_in_rhesus_monkeys_ L2 - https://journals.physiology.org/doi/10.1152/ajplung.00467.2006?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -