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Exposure to marijuana smoke impairs memory retrieval in mice.
J Pharmacol Exp Ther. 2007 Sep; 322(3):1067-75.JP

Abstract

Marijuana (Cannabis sativa) and its primary psychoactive component, delta-9-tetrahydrocannabinol (Delta(9)-THC), have long been known to disrupt cognition in humans. Although Delta(9)-THC and other cannabinoids disrupt performance in a wide range of animal models of learning and memory, few studies have investigated the effects of smoked marijuana in these paradigms. Moreover, in preclinical studies, cannabinoids are generally administered before acquisition, and because retention is generally evaluated soon afterward, it is difficult to distinguish between processes related to acquisition and retrieval. In the present study, we investigated the specific effects of marijuana smoke and injected Delta(9)-THC on acquisition versus memory retrieval in a mouse repeated acquisition Morris water-maze task. To distinguish between these processes, subjects were administered Delta(9)-THC or they were exposed to marijuana smoke either 30 min before acquisition or 30 min before the retention test. Inhalation of marijuana smoke or injected Delta(9)-THC impaired the ability of the mice to learn the location of the hidden platform and to recall the platform location once learning had already taken place. In contrast, neither drug impaired performance in a cued task in which the platform was made visible. Finally, the cannabinoid-1 (CB(1)) receptor antagonist N-(piperidin-1-yl)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide HCl (rimonabant) blocked the memory disruptive effects of both Delta(9)-THC and marijuana. These data represent the first evidence demonstrating that marijuana impairs memory retrieval through a CB(1) receptor mechanism of action and independently of its effects on sensorimotor performance, motivation, and initial acquisition.

Authors+Show Affiliations

Department of Pharmacology and Toxicology, Medical College of Virginia Campus, Virginia Commonwealth University, Box 980613, Richmond, VA 23298-0613, USA.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

17586723

Citation

Niyuhire, Floride, et al. "Exposure to Marijuana Smoke Impairs Memory Retrieval in Mice." The Journal of Pharmacology and Experimental Therapeutics, vol. 322, no. 3, 2007, pp. 1067-75.
Niyuhire F, Varvel SA, Martin BR, et al. Exposure to marijuana smoke impairs memory retrieval in mice. J Pharmacol Exp Ther. 2007;322(3):1067-75.
Niyuhire, F., Varvel, S. A., Martin, B. R., & Lichtman, A. H. (2007). Exposure to marijuana smoke impairs memory retrieval in mice. The Journal of Pharmacology and Experimental Therapeutics, 322(3), 1067-75.
Niyuhire F, et al. Exposure to Marijuana Smoke Impairs Memory Retrieval in Mice. J Pharmacol Exp Ther. 2007;322(3):1067-75. PubMed PMID: 17586723.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Exposure to marijuana smoke impairs memory retrieval in mice. AU - Niyuhire,Floride, AU - Varvel,Stephen A, AU - Martin,Billy R, AU - Lichtman,Aron H, Y1 - 2007/06/22/ PY - 2007/6/26/pubmed PY - 2007/10/20/medline PY - 2007/6/26/entrez SP - 1067 EP - 75 JF - The Journal of pharmacology and experimental therapeutics JO - J Pharmacol Exp Ther VL - 322 IS - 3 N2 - Marijuana (Cannabis sativa) and its primary psychoactive component, delta-9-tetrahydrocannabinol (Delta(9)-THC), have long been known to disrupt cognition in humans. Although Delta(9)-THC and other cannabinoids disrupt performance in a wide range of animal models of learning and memory, few studies have investigated the effects of smoked marijuana in these paradigms. Moreover, in preclinical studies, cannabinoids are generally administered before acquisition, and because retention is generally evaluated soon afterward, it is difficult to distinguish between processes related to acquisition and retrieval. In the present study, we investigated the specific effects of marijuana smoke and injected Delta(9)-THC on acquisition versus memory retrieval in a mouse repeated acquisition Morris water-maze task. To distinguish between these processes, subjects were administered Delta(9)-THC or they were exposed to marijuana smoke either 30 min before acquisition or 30 min before the retention test. Inhalation of marijuana smoke or injected Delta(9)-THC impaired the ability of the mice to learn the location of the hidden platform and to recall the platform location once learning had already taken place. In contrast, neither drug impaired performance in a cued task in which the platform was made visible. Finally, the cannabinoid-1 (CB(1)) receptor antagonist N-(piperidin-1-yl)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide HCl (rimonabant) blocked the memory disruptive effects of both Delta(9)-THC and marijuana. These data represent the first evidence demonstrating that marijuana impairs memory retrieval through a CB(1) receptor mechanism of action and independently of its effects on sensorimotor performance, motivation, and initial acquisition. SN - 0022-3565 UR - https://www.unboundmedicine.com/medline/citation/17586723/Exposure_to_marijuana_smoke_impairs_memory_retrieval_in_mice_ DB - PRIME DP - Unbound Medicine ER -