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Carbohydrate versus energy restriction: effects on weight loss, body composition and metabolism.
Ann Nutr Metab. 2007; 51(3):232-43.AN

Abstract

BACKGROUND/AIMS

To compare weight loss, body composition, and metabolic changes in response to carbohydrate versus dietary energy restriction (DER) in obese mice.

METHODS

One hundred C57BL/6 mice were randomized into five groups of 20. The group of high-carbohydrate (HC) mice consumed an HC diet ad libitum and the group of high-fat (HF) mice consumed an HF diet ad libitum for 14 weeks. Additional groups consumed the HF diet for 7 weeks ad libitum and during weeks 8-14 were switched to either a low-carbohydrate diet (LC) consumed ad libitum, the HC diet pair-fed (PF) to the energy intake of the LC group, or an HC DER regimen providing 70% of the energy intake of the HF group.

RESULTS

At 14 weeks, the LC and HF groups weighed more and exhibited higher percent fat mass and lower bone mineral density than the HC, PF, and DER groups. Relative to the DER group, the LC group displayed comparable serum ketone bodies but higher serum glucose, triglycerides, cholesterol, leptin, insulin, and insulin-like growth factor-1.

CONCLUSIONS

In contrast to DER, the LC diet did not cause weight loss or reduce serum markers associated with obesity-related diseases other than diabetes in obese mice, suggesting that carbohydraterestriction without reduced energy intake does not induce weight loss.

Authors+Show Affiliations

Division of Nutritional Sciences, Department of Human Ecology at the University of Texas at Austin, Austin, TX 78712, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17587795

Citation

Williams, Elizabeth A., et al. "Carbohydrate Versus Energy Restriction: Effects On Weight Loss, Body Composition and Metabolism." Annals of Nutrition & Metabolism, vol. 51, no. 3, 2007, pp. 232-43.
Williams EA, Perkins SN, Smith NC, et al. Carbohydrate versus energy restriction: effects on weight loss, body composition and metabolism. Ann Nutr Metab. 2007;51(3):232-43.
Williams, E. A., Perkins, S. N., Smith, N. C., Hursting, S. D., & Lane, M. A. (2007). Carbohydrate versus energy restriction: effects on weight loss, body composition and metabolism. Annals of Nutrition & Metabolism, 51(3), 232-43.
Williams EA, et al. Carbohydrate Versus Energy Restriction: Effects On Weight Loss, Body Composition and Metabolism. Ann Nutr Metab. 2007;51(3):232-43. PubMed PMID: 17587795.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Carbohydrate versus energy restriction: effects on weight loss, body composition and metabolism. AU - Williams,Elizabeth A, AU - Perkins,Susan N, AU - Smith,Nicole C P, AU - Hursting,Stephen D, AU - Lane,Michelle A, Y1 - 2007/06/18/ PY - 2006/08/08/received PY - 2007/03/27/accepted PY - 2007/6/26/pubmed PY - 2007/10/3/medline PY - 2007/6/26/entrez SP - 232 EP - 43 JF - Annals of nutrition & metabolism JO - Ann. Nutr. Metab. VL - 51 IS - 3 N2 - BACKGROUND/AIMS: To compare weight loss, body composition, and metabolic changes in response to carbohydrate versus dietary energy restriction (DER) in obese mice. METHODS: One hundred C57BL/6 mice were randomized into five groups of 20. The group of high-carbohydrate (HC) mice consumed an HC diet ad libitum and the group of high-fat (HF) mice consumed an HF diet ad libitum for 14 weeks. Additional groups consumed the HF diet for 7 weeks ad libitum and during weeks 8-14 were switched to either a low-carbohydrate diet (LC) consumed ad libitum, the HC diet pair-fed (PF) to the energy intake of the LC group, or an HC DER regimen providing 70% of the energy intake of the HF group. RESULTS: At 14 weeks, the LC and HF groups weighed more and exhibited higher percent fat mass and lower bone mineral density than the HC, PF, and DER groups. Relative to the DER group, the LC group displayed comparable serum ketone bodies but higher serum glucose, triglycerides, cholesterol, leptin, insulin, and insulin-like growth factor-1. CONCLUSIONS: In contrast to DER, the LC diet did not cause weight loss or reduce serum markers associated with obesity-related diseases other than diabetes in obese mice, suggesting that carbohydraterestriction without reduced energy intake does not induce weight loss. SN - 1421-9697 UR - https://www.unboundmedicine.com/medline/citation/17587795/Carbohydrate_versus_energy_restriction:_effects_on_weight_loss_body_composition_and_metabolism_ L2 - https://www.karger.com?DOI=10.1159/000104143 DB - PRIME DP - Unbound Medicine ER -