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Enhanced dissolution of oxcarbazepine microcrystals using a static mixer process.
Colloids Surf B Biointerfaces. 2007 Oct 01; 59(2):208-14.CS

Abstract

The purpose of this study was to form micronized powders of Oxcarbazepine (OXC), a poorly water-soluble drug, using a static mixer technique to enhance the dissolution rate. Controlled precipitation was achieved injecting the organic OXC solution rapidly into an aqueous methylcellulose (MC) protective solution by means of a static mixer thus providing turbulent and homogeneous mixing. Furthermore, a factorial design was implemented for data analysis. The physicochemical properties of the freeze-dried dispersions were evaluated by differential scanning calorimetry (DSC), infrared spectroscopy (FTIR) and X-ray diffraction (XRD). Drug microcrystals showed a narrow size distribution with approximately 2 microm mean particle size and high drug loading. DSC and FTIR studies revealed that the drug remained in crystalline state and no drug-polymer interaction occurred. The dissolution studies showed enhanced dissolution of OXC microcrystals compared to the pure drug. The static mixer technique was proved capable for micro-sized polymeric particles. This is an inexpensive, less time consuming and fully scalable process for development of poorly soluble drugs.

Authors+Show Affiliations

Douroumis D
Department of Pharmaceutical Technology, Friedrich-Schiller University of Jena, Lessing Strasse 8, D-07743 Jena, Germany. dionysios.douroumis@phoqus.com
Fahr A
No affiliation info available

MeSH

Calorimetry, Differential ScanningCarbamazepineChemical PrecipitationCrystallizationOxcarbazepineParticle SizePowdersSolubilitySpectroscopy, Fourier Transform InfraredX-Ray Diffraction

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17588726

Citation

Douroumis, D, and A Fahr. "Enhanced Dissolution of Oxcarbazepine Microcrystals Using a Static Mixer Process." Colloids and Surfaces. B, Biointerfaces, vol. 59, no. 2, 2007, pp. 208-14.
Douroumis D, Fahr A. Enhanced dissolution of oxcarbazepine microcrystals using a static mixer process. Colloids Surf B Biointerfaces. 2007;59(2):208-14.
Douroumis, D., & Fahr, A. (2007). Enhanced dissolution of oxcarbazepine microcrystals using a static mixer process. Colloids and Surfaces. B, Biointerfaces, 59(2), 208-14.
Douroumis D, Fahr A. Enhanced Dissolution of Oxcarbazepine Microcrystals Using a Static Mixer Process. Colloids Surf B Biointerfaces. 2007 Oct 1;59(2):208-14. PubMed PMID: 17588726.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Enhanced dissolution of oxcarbazepine microcrystals using a static mixer process. AU - Douroumis,D, AU - Fahr,A, Y1 - 2007/05/18/ PY - 2006/09/18/received PY - 2007/05/04/revised PY - 2007/05/09/accepted PY - 2007/6/26/pubmed PY - 2008/9/3/medline PY - 2007/6/26/entrez SP - 208 EP - 14 JF - Colloids and surfaces. B, Biointerfaces JO - Colloids Surf B Biointerfaces VL - 59 IS - 2 N2 - The purpose of this study was to form micronized powders of Oxcarbazepine (OXC), a poorly water-soluble drug, using a static mixer technique to enhance the dissolution rate. Controlled precipitation was achieved injecting the organic OXC solution rapidly into an aqueous methylcellulose (MC) protective solution by means of a static mixer thus providing turbulent and homogeneous mixing. Furthermore, a factorial design was implemented for data analysis. The physicochemical properties of the freeze-dried dispersions were evaluated by differential scanning calorimetry (DSC), infrared spectroscopy (FTIR) and X-ray diffraction (XRD). Drug microcrystals showed a narrow size distribution with approximately 2 microm mean particle size and high drug loading. DSC and FTIR studies revealed that the drug remained in crystalline state and no drug-polymer interaction occurred. The dissolution studies showed enhanced dissolution of OXC microcrystals compared to the pure drug. The static mixer technique was proved capable for micro-sized polymeric particles. This is an inexpensive, less time consuming and fully scalable process for development of poorly soluble drugs. SN - 0927-7765 UR - https://www.unboundmedicine.com/medline/citation/17588726/Enhanced_dissolution_of_oxcarbazepine_microcrystals_using_a_static_mixer_process_ DB - PRIME DP - Unbound Medicine ER -