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Monoaminergic agents modulate antidepressant-like effect caused by diphenyl diselenide in rats.
Prog Neuropsychopharmacol Biol Psychiatry. 2007 Aug 15; 31(6):1261-9.PN

Abstract

In this study, the antidepressant-like effect caused by diphenyl diselenide on rat forced swimming test (FST) was investigated. The involvement of the monoaminergic system in the antidepressant-like effect was also evaluated. Diphenyl diselenide (0.1-30 mg/kg), given by oral route (p.o.), 30 min earlier, reduced the immobility time in the FST, without accompanying changes in ambulation when assessed in an open field. The anti-immobility effect of diphenyl diselenide (1 mg/kg, p.o.) on the FST was prevented by pretreatment of rats with p-chlorophenylalanine methyl ester (PCPA; 100 mg/kg, i.p., an inhibitor of serotonin synthesis, given once a day, for 3 consecutive days), WAY100635 (0.1 mg/kg, s.c., a selective 5-HT(1A) receptor antagonist), ketanserin (1 mg/kg, i.p., a 5-HT(2A)/(2C) receptor antagonist), ondasentron (1 mg/kg, i.p., a 5-HT(3) receptor antagonist), haloperidol (1 mg/kg, i.p., a D(1), D(2) and D(3) receptor antagonist), SCH233390 (0.05 mg/kg, s.c., a D(1) receptor antagonist), sulpiride (50 mg/kg, i.p., a D(2) receptor antagonist), prazosin (1 mg/kg, i.p., an alpha(1)-adrenoceptor antagonist), yohimbine (1 mg/kg, i.p., an alpha(2)-adrenoceptor antagonist). However, the anti-immobility effect caused by diphenyl diselenide (1 mg/kg, p.o.) on the FST was not affected by pretreatment with propanolol (2 mg/kg, i.p., a beta-adrenoceptor antagonist). Furthermore, monoamine oxidase (MAO) activity was inhibited (39%) in the animals treated with diphenyl diselenide (30 mg/kg, p.o.) when compared to the control group. Taken together these data demonstrated that the antidepressant-like effect caused by diphenyl diselenide seems to be mediated by involvement of the central monoaminergic system.

Authors+Show Affiliations

Laboratório de Síntese, Reatividade e Avaliação Farmacológica e Toxicológica de Organocalcogênios, Centro de Ciências Naturais e Exatas, Universidade Federal de Santa Maria, 97105-900, Santa Maria, RS, Brazil.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17590255

Citation

Savegnago, Lucielli, et al. "Monoaminergic Agents Modulate Antidepressant-like Effect Caused By Diphenyl Diselenide in Rats." Progress in Neuro-psychopharmacology & Biological Psychiatry, vol. 31, no. 6, 2007, pp. 1261-9.
Savegnago L, Jesse CR, Pinto LG, et al. Monoaminergic agents modulate antidepressant-like effect caused by diphenyl diselenide in rats. Prog Neuropsychopharmacol Biol Psychiatry. 2007;31(6):1261-9.
Savegnago, L., Jesse, C. R., Pinto, L. G., Rocha, J. B., Nogueira, C. W., & Zeni, G. (2007). Monoaminergic agents modulate antidepressant-like effect caused by diphenyl diselenide in rats. Progress in Neuro-psychopharmacology & Biological Psychiatry, 31(6), 1261-9.
Savegnago L, et al. Monoaminergic Agents Modulate Antidepressant-like Effect Caused By Diphenyl Diselenide in Rats. Prog Neuropsychopharmacol Biol Psychiatry. 2007 Aug 15;31(6):1261-9. PubMed PMID: 17590255.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Monoaminergic agents modulate antidepressant-like effect caused by diphenyl diselenide in rats. AU - Savegnago,Lucielli, AU - Jesse,Cristiano R, AU - Pinto,Larissa G, AU - Rocha,Joao B T, AU - Nogueira,Cristina W, AU - Zeni,Gilson, Y1 - 2007/05/25/ PY - 2007/03/10/received PY - 2007/04/28/revised PY - 2007/05/17/accepted PY - 2007/6/26/pubmed PY - 2007/11/1/medline PY - 2007/6/26/entrez SP - 1261 EP - 9 JF - Progress in neuro-psychopharmacology & biological psychiatry JO - Prog Neuropsychopharmacol Biol Psychiatry VL - 31 IS - 6 N2 - In this study, the antidepressant-like effect caused by diphenyl diselenide on rat forced swimming test (FST) was investigated. The involvement of the monoaminergic system in the antidepressant-like effect was also evaluated. Diphenyl diselenide (0.1-30 mg/kg), given by oral route (p.o.), 30 min earlier, reduced the immobility time in the FST, without accompanying changes in ambulation when assessed in an open field. The anti-immobility effect of diphenyl diselenide (1 mg/kg, p.o.) on the FST was prevented by pretreatment of rats with p-chlorophenylalanine methyl ester (PCPA; 100 mg/kg, i.p., an inhibitor of serotonin synthesis, given once a day, for 3 consecutive days), WAY100635 (0.1 mg/kg, s.c., a selective 5-HT(1A) receptor antagonist), ketanserin (1 mg/kg, i.p., a 5-HT(2A)/(2C) receptor antagonist), ondasentron (1 mg/kg, i.p., a 5-HT(3) receptor antagonist), haloperidol (1 mg/kg, i.p., a D(1), D(2) and D(3) receptor antagonist), SCH233390 (0.05 mg/kg, s.c., a D(1) receptor antagonist), sulpiride (50 mg/kg, i.p., a D(2) receptor antagonist), prazosin (1 mg/kg, i.p., an alpha(1)-adrenoceptor antagonist), yohimbine (1 mg/kg, i.p., an alpha(2)-adrenoceptor antagonist). However, the anti-immobility effect caused by diphenyl diselenide (1 mg/kg, p.o.) on the FST was not affected by pretreatment with propanolol (2 mg/kg, i.p., a beta-adrenoceptor antagonist). Furthermore, monoamine oxidase (MAO) activity was inhibited (39%) in the animals treated with diphenyl diselenide (30 mg/kg, p.o.) when compared to the control group. Taken together these data demonstrated that the antidepressant-like effect caused by diphenyl diselenide seems to be mediated by involvement of the central monoaminergic system. SN - 0278-5846 UR - https://www.unboundmedicine.com/medline/citation/17590255/Monoaminergic_agents_modulate_antidepressant_like_effect_caused_by_diphenyl_diselenide_in_rats_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0278-5846(07)00178-9 DB - PRIME DP - Unbound Medicine ER -