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The effects of energy-rich diets on discrimination reversal learning and on BDNF in the hippocampus and prefrontal cortex of the rat.

Abstract

Male rats received normal chow or high-fat diets rich in dextrose (HFD) or sucrose (HFS). Half of the rats received 90-day unrestricted access to their diet prior to training, whereas the other half were food restricted throughout the study. We evaluated the effects of these dietary manipulations on discrimination and reversal performance and on post-training levels of brain-derived neurotrophic factor (BDNF) in the prefrontal cortex and the ventral and dorsal hippocampus. Neither diet nor restriction condition affected discrimination acquisition. However, prior unrestricted access to the HFD diet impaired discrimination reversal learning and reduced BDNF in the prefrontal cortex and ventral hippocampus. Also, rats given the HFD diet responded more than controls to the previously rewarded cue at the outset of discrimination reversal. The results suggest that consumption of the HFD diet may have had enduring effects on learning processes, some of which may contribute to the control of intake regulation.

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  • Authors+Show Affiliations

    ,

    The Ingestive Behavior Research Center, Purdue University, IN, USA. skanoski@purdue.edu

    , ,

    Source

    Behavioural brain research 182:1 2007 Aug 22 pg 57-66

    MeSH

    Analysis of Variance
    Animals
    Avoidance Learning
    Behavior, Animal
    Body Weight
    Brain-Derived Neurotrophic Factor
    Dietary Fats
    Discrimination (Psychology)
    Hippocampus
    Male
    Prefrontal Cortex
    Rats
    Rats, Sprague-Dawley

    Pub Type(s)

    Journal Article
    Research Support, N.I.H., Extramural

    Language

    eng

    PubMed ID

    17590450

    Citation

    Kanoski, Scott E., et al. "The Effects of Energy-rich Diets On Discrimination Reversal Learning and On BDNF in the Hippocampus and Prefrontal Cortex of the Rat." Behavioural Brain Research, vol. 182, no. 1, 2007, pp. 57-66.
    Kanoski SE, Meisel RL, Mullins AJ, et al. The effects of energy-rich diets on discrimination reversal learning and on BDNF in the hippocampus and prefrontal cortex of the rat. Behav Brain Res. 2007;182(1):57-66.
    Kanoski, S. E., Meisel, R. L., Mullins, A. J., & Davidson, T. L. (2007). The effects of energy-rich diets on discrimination reversal learning and on BDNF in the hippocampus and prefrontal cortex of the rat. Behavioural Brain Research, 182(1), pp. 57-66.
    Kanoski SE, et al. The Effects of Energy-rich Diets On Discrimination Reversal Learning and On BDNF in the Hippocampus and Prefrontal Cortex of the Rat. Behav Brain Res. 2007 Aug 22;182(1):57-66. PubMed PMID: 17590450.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - The effects of energy-rich diets on discrimination reversal learning and on BDNF in the hippocampus and prefrontal cortex of the rat. AU - Kanoski,Scott E, AU - Meisel,Robert L, AU - Mullins,Amanda J, AU - Davidson,Terry L, Y1 - 2007/05/22/ PY - 2007/02/08/received PY - 2007/04/26/revised PY - 2007/05/07/accepted PY - 2007/6/26/pubmed PY - 2007/10/13/medline PY - 2007/6/26/entrez SP - 57 EP - 66 JF - Behavioural brain research JO - Behav. Brain Res. VL - 182 IS - 1 N2 - Male rats received normal chow or high-fat diets rich in dextrose (HFD) or sucrose (HFS). Half of the rats received 90-day unrestricted access to their diet prior to training, whereas the other half were food restricted throughout the study. We evaluated the effects of these dietary manipulations on discrimination and reversal performance and on post-training levels of brain-derived neurotrophic factor (BDNF) in the prefrontal cortex and the ventral and dorsal hippocampus. Neither diet nor restriction condition affected discrimination acquisition. However, prior unrestricted access to the HFD diet impaired discrimination reversal learning and reduced BDNF in the prefrontal cortex and ventral hippocampus. Also, rats given the HFD diet responded more than controls to the previously rewarded cue at the outset of discrimination reversal. The results suggest that consumption of the HFD diet may have had enduring effects on learning processes, some of which may contribute to the control of intake regulation. SN - 0166-4328 UR - https://www.unboundmedicine.com/medline/citation/17590450/The_effects_of_energy_rich_diets_on_discrimination_reversal_learning_and_on_BDNF_in_the_hippocampus_and_prefrontal_cortex_of_the_rat_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0166-4328(07)00251-3 DB - PRIME DP - Unbound Medicine ER -