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The effects of energy-rich diets on discrimination reversal learning and on BDNF in the hippocampus and prefrontal cortex of the rat.
Behav Brain Res. 2007 Aug 22; 182(1):57-66.BB

Abstract

Male rats received normal chow or high-fat diets rich in dextrose (HFD) or sucrose (HFS). Half of the rats received 90-day unrestricted access to their diet prior to training, whereas the other half were food restricted throughout the study. We evaluated the effects of these dietary manipulations on discrimination and reversal performance and on post-training levels of brain-derived neurotrophic factor (BDNF) in the prefrontal cortex and the ventral and dorsal hippocampus. Neither diet nor restriction condition affected discrimination acquisition. However, prior unrestricted access to the HFD diet impaired discrimination reversal learning and reduced BDNF in the prefrontal cortex and ventral hippocampus. Also, rats given the HFD diet responded more than controls to the previously rewarded cue at the outset of discrimination reversal. The results suggest that consumption of the HFD diet may have had enduring effects on learning processes, some of which may contribute to the control of intake regulation.

Authors+Show Affiliations

The Ingestive Behavior Research Center, Purdue University, IN, USA. skanoski@purdue.eduNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

17590450

Citation

Kanoski, Scott E., et al. "The Effects of Energy-rich Diets On Discrimination Reversal Learning and On BDNF in the Hippocampus and Prefrontal Cortex of the Rat." Behavioural Brain Research, vol. 182, no. 1, 2007, pp. 57-66.
Kanoski SE, Meisel RL, Mullins AJ, et al. The effects of energy-rich diets on discrimination reversal learning and on BDNF in the hippocampus and prefrontal cortex of the rat. Behav Brain Res. 2007;182(1):57-66.
Kanoski, S. E., Meisel, R. L., Mullins, A. J., & Davidson, T. L. (2007). The effects of energy-rich diets on discrimination reversal learning and on BDNF in the hippocampus and prefrontal cortex of the rat. Behavioural Brain Research, 182(1), 57-66.
Kanoski SE, et al. The Effects of Energy-rich Diets On Discrimination Reversal Learning and On BDNF in the Hippocampus and Prefrontal Cortex of the Rat. Behav Brain Res. 2007 Aug 22;182(1):57-66. PubMed PMID: 17590450.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effects of energy-rich diets on discrimination reversal learning and on BDNF in the hippocampus and prefrontal cortex of the rat. AU - Kanoski,Scott E, AU - Meisel,Robert L, AU - Mullins,Amanda J, AU - Davidson,Terry L, Y1 - 2007/05/22/ PY - 2007/02/08/received PY - 2007/04/26/revised PY - 2007/05/07/accepted PY - 2007/6/26/pubmed PY - 2007/10/13/medline PY - 2007/6/26/entrez SP - 57 EP - 66 JF - Behavioural brain research JO - Behav. Brain Res. VL - 182 IS - 1 N2 - Male rats received normal chow or high-fat diets rich in dextrose (HFD) or sucrose (HFS). Half of the rats received 90-day unrestricted access to their diet prior to training, whereas the other half were food restricted throughout the study. We evaluated the effects of these dietary manipulations on discrimination and reversal performance and on post-training levels of brain-derived neurotrophic factor (BDNF) in the prefrontal cortex and the ventral and dorsal hippocampus. Neither diet nor restriction condition affected discrimination acquisition. However, prior unrestricted access to the HFD diet impaired discrimination reversal learning and reduced BDNF in the prefrontal cortex and ventral hippocampus. Also, rats given the HFD diet responded more than controls to the previously rewarded cue at the outset of discrimination reversal. The results suggest that consumption of the HFD diet may have had enduring effects on learning processes, some of which may contribute to the control of intake regulation. SN - 0166-4328 UR - https://www.unboundmedicine.com/medline/citation/17590450/The_effects_of_energy_rich_diets_on_discrimination_reversal_learning_and_on_BDNF_in_the_hippocampus_and_prefrontal_cortex_of_the_rat_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0166-4328(07)00251-3 DB - PRIME DP - Unbound Medicine ER -