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Nicotine receptor gene CHRNA4 modulates early event-related potentials in auditory and visual oddball target detection tasks.
Neuroscience. 2007 Jul 29; 147(4):974-85.N

Abstract

The present study seeks to identify effects of a common genetic polymorphism in the human nicotinic alpha4beta2 receptor on components of the cognitive event-related potentials in auditory and visual modalities. The same sense thymine-to-cytosine polymorphism (c.1629T-C; Ser543Ser) was shown to preferentially modulate early components in both modalities. Specifically, the auditory N1 component amplitude was higher for T allele homozygotes than for C allele carriers. The visual P1 component revealed the same pattern of significant polymorphic modulation, but the later N1 amplitude differences were only marginally significant. There was no reliable indication of interactions between genotype and task factors. Parallel modulation of early latency modality-specific event-related potential (ERP) components in vision and audition may indicate that the CHRNA4 polymorphism affects factors that are common to top-down modulation of sensory processing across modalities.

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Authors+Show Affiliations

Espeseth T
Center for the Study of Human Cognition, Department of Psychology, University of Oslo, and Department of Medical Biochemistry, Rikshospitalet-Radiumhospitalet Medical Center, Oslo, Norway. thomas.espeseth@psykologi.uio.no
Endestad T
No affiliation info available
Rootwelt H
No affiliation info available
Reinvang I
No affiliation info available

MeSH

Acoustic StimulationAgedAnalysis of VarianceApolipoproteins EAttentionAuditory PerceptionElectroencephalographyEvoked Potentials, AuditoryEvoked Potentials, VisualFemaleHumansMaleMiddle AgedPhotic StimulationPolymorphism, GeneticReaction TimeReceptors, NicotinicSerineVisual Perception

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17590520

Citation

Espeseth, T, et al. "Nicotine Receptor Gene CHRNA4 Modulates Early Event-related Potentials in Auditory and Visual Oddball Target Detection Tasks." Neuroscience, vol. 147, no. 4, 2007, pp. 974-85.
Espeseth T, Endestad T, Rootwelt H, et al. Nicotine receptor gene CHRNA4 modulates early event-related potentials in auditory and visual oddball target detection tasks. Neuroscience. 2007;147(4):974-85.
Espeseth, T., Endestad, T., Rootwelt, H., & Reinvang, I. (2007). Nicotine receptor gene CHRNA4 modulates early event-related potentials in auditory and visual oddball target detection tasks. Neuroscience, 147(4), 974-85.
Espeseth T, et al. Nicotine Receptor Gene CHRNA4 Modulates Early Event-related Potentials in Auditory and Visual Oddball Target Detection Tasks. Neuroscience. 2007 Jul 29;147(4):974-85. PubMed PMID: 17590520.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Nicotine receptor gene CHRNA4 modulates early event-related potentials in auditory and visual oddball target detection tasks. AU - Espeseth,T, AU - Endestad,T, AU - Rootwelt,H, AU - Reinvang,I, Y1 - 2007/06/27/ PY - 2007/01/12/received PY - 2007/03/30/revised PY - 2007/04/16/accepted PY - 2007/6/26/pubmed PY - 2007/11/1/medline PY - 2007/6/26/entrez SP - 974 EP - 85 JF - Neuroscience JO - Neuroscience VL - 147 IS - 4 N2 - The present study seeks to identify effects of a common genetic polymorphism in the human nicotinic alpha4beta2 receptor on components of the cognitive event-related potentials in auditory and visual modalities. The same sense thymine-to-cytosine polymorphism (c.1629T-C; Ser543Ser) was shown to preferentially modulate early components in both modalities. Specifically, the auditory N1 component amplitude was higher for T allele homozygotes than for C allele carriers. The visual P1 component revealed the same pattern of significant polymorphic modulation, but the later N1 amplitude differences were only marginally significant. There was no reliable indication of interactions between genotype and task factors. Parallel modulation of early latency modality-specific event-related potential (ERP) components in vision and audition may indicate that the CHRNA4 polymorphism affects factors that are common to top-down modulation of sensory processing across modalities. SN - 0306-4522 UR - https://www.unboundmedicine.com/medline/citation/17590520/Nicotine_receptor_gene_CHRNA4_modulates_early_event_related_potentials_in_auditory_and_visual_oddball_target_detection_tasks_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0306-4522(07)00534-9 DB - PRIME DP - Unbound Medicine ER -