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ACE inhibitors and persistent left ventricular hypertrophy after renal transplantation: a randomized clinical trial.
Am J Kidney Dis. 2007 Jul; 50(1):133-42.AJ

Abstract

BACKGROUND

Interventional studies of left ventricular hypertrophy (LVH) in renal transplant recipients are scarce and to date evaluated only patients immediately after renal transplantation.

STUDY DESIGN

Randomized controlled trial that assessed the effectiveness of angiotensin-converting enzyme (ACE) inhibitors in regressing persistent LVH after successful transplantation.

SETTING & PARTICIPANTS

70 renal transplant recipients (47 men; age, 30 to 68 years) without diabetes previously randomly assigned to either cyclosporine or tacrolimus therapy, with LVH persisting 3 to 6 months after transplantation.

INTERVENTION

Subjects were randomly assigned to either lisinopril (ACE-inhibitor group; 36 patients) or no therapy (control group; 34 subjects).

OUTCOMES

Main outcome was change in left ventricular mass index (LVMi) at month 18.

RESULTS

A consistent decrease in both systolic (SBP) and diastolic blood pressure (DBP) was observed in both groups (between-group differences, -1.7 +/- 3.3 mm Hg; 95% confidence interval [CI], -4.8 to 8.2; P = 0.6 for SBP; 0.3 +/- 2.2 mm Hg; 95% CI, -4.8 to 4.1; P = 0.9 for DBP), whereas LVMi regressed more in the ACE-inhibitor group (between-group difference, 10.1 +/- 16.3 g/m(2.7); 95% CI, 4.2 to 16.1; P < 0.01). A significant interaction of ACE inhibitors with cyclosporine in affecting LVMi change was shown by means of post hoc multiple regression analysis (P < 0.01; differences between cyclosporine and tacrolimus group, 13.3 +/- 3.9 g/m(2.7); 95% CI, 5.3 to 21.2; P < 0.01 in the ACE-inhibitor group; 3.7 +/- 4.2 g/m(2.7); 95% CI, -4.7 to 12.2; P = 0.4 in the control group).

LIMITATIONS

Single-center study with small sample size. Interaction of ACE inhibitors with cyclosporine treatment emerged from post hoc analysis.

CONCLUSION

A prolonged course of ACE-inhibitor therapy is effective in regressing the persistent LVH of renal transplant recipients by mechanisms independent of effects on BP. This regression seems to be at least in part the effect of an interaction between ACE inhibitors and cyclosporine.

Authors+Show Affiliations

Divisione di Nefrologia, Dialisi e Trapianto, Azienda Ospedaliera Universitaria S. Martino, Genova, Italy. ernesto.paoletti@hsanmartino.it <ernesto.paoletti@hsanmartino.it>No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

17591533

Citation

Paoletti, Ernesto, et al. "ACE Inhibitors and Persistent Left Ventricular Hypertrophy After Renal Transplantation: a Randomized Clinical Trial." American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation, vol. 50, no. 1, 2007, pp. 133-42.
Paoletti E, Cassottana P, Amidone M, et al. ACE inhibitors and persistent left ventricular hypertrophy after renal transplantation: a randomized clinical trial. Am J Kidney Dis. 2007;50(1):133-42.
Paoletti, E., Cassottana, P., Amidone, M., Gherzi, M., Rolla, D., & Cannella, G. (2007). ACE inhibitors and persistent left ventricular hypertrophy after renal transplantation: a randomized clinical trial. American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation, 50(1), 133-42.
Paoletti E, et al. ACE Inhibitors and Persistent Left Ventricular Hypertrophy After Renal Transplantation: a Randomized Clinical Trial. Am J Kidney Dis. 2007;50(1):133-42. PubMed PMID: 17591533.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - ACE inhibitors and persistent left ventricular hypertrophy after renal transplantation: a randomized clinical trial. AU - Paoletti,Ernesto, AU - Cassottana,Paolo, AU - Amidone,Marco, AU - Gherzi,Maurizio, AU - Rolla,Davide, AU - Cannella,Giuseppe, PY - 2006/11/01/received PY - 2007/04/13/accepted PY - 2007/6/27/pubmed PY - 2007/6/29/medline PY - 2007/6/27/entrez SP - 133 EP - 42 JF - American journal of kidney diseases : the official journal of the National Kidney Foundation JO - Am J Kidney Dis VL - 50 IS - 1 N2 - BACKGROUND: Interventional studies of left ventricular hypertrophy (LVH) in renal transplant recipients are scarce and to date evaluated only patients immediately after renal transplantation. STUDY DESIGN: Randomized controlled trial that assessed the effectiveness of angiotensin-converting enzyme (ACE) inhibitors in regressing persistent LVH after successful transplantation. SETTING & PARTICIPANTS: 70 renal transplant recipients (47 men; age, 30 to 68 years) without diabetes previously randomly assigned to either cyclosporine or tacrolimus therapy, with LVH persisting 3 to 6 months after transplantation. INTERVENTION: Subjects were randomly assigned to either lisinopril (ACE-inhibitor group; 36 patients) or no therapy (control group; 34 subjects). OUTCOMES: Main outcome was change in left ventricular mass index (LVMi) at month 18. RESULTS: A consistent decrease in both systolic (SBP) and diastolic blood pressure (DBP) was observed in both groups (between-group differences, -1.7 +/- 3.3 mm Hg; 95% confidence interval [CI], -4.8 to 8.2; P = 0.6 for SBP; 0.3 +/- 2.2 mm Hg; 95% CI, -4.8 to 4.1; P = 0.9 for DBP), whereas LVMi regressed more in the ACE-inhibitor group (between-group difference, 10.1 +/- 16.3 g/m(2.7); 95% CI, 4.2 to 16.1; P < 0.01). A significant interaction of ACE inhibitors with cyclosporine in affecting LVMi change was shown by means of post hoc multiple regression analysis (P < 0.01; differences between cyclosporine and tacrolimus group, 13.3 +/- 3.9 g/m(2.7); 95% CI, 5.3 to 21.2; P < 0.01 in the ACE-inhibitor group; 3.7 +/- 4.2 g/m(2.7); 95% CI, -4.7 to 12.2; P = 0.4 in the control group). LIMITATIONS: Single-center study with small sample size. Interaction of ACE inhibitors with cyclosporine treatment emerged from post hoc analysis. CONCLUSION: A prolonged course of ACE-inhibitor therapy is effective in regressing the persistent LVH of renal transplant recipients by mechanisms independent of effects on BP. This regression seems to be at least in part the effect of an interaction between ACE inhibitors and cyclosporine. SN - 1523-6838 UR - https://www.unboundmedicine.com/medline/citation/17591533/ACE_inhibitors_and_persistent_left_ventricular_hypertrophy_after_renal_transplantation:_a_randomized_clinical_trial_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0272-6386(07)00734-2 DB - PRIME DP - Unbound Medicine ER -