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Renal cell cancer and body size at different ages: an Italian multicenter case-control study.
Am J Epidemiol 2007; 166(5):582-91AJ

Abstract

An increased risk of renal cell cancer (RCC) has been reported in overweight persons. The authors aimed to clarify which anthropometric measures are associated with risk of RCC and whether risk may vary according to selected variables. Between 1992 and 2004, they carried out an Italian multicenter case-control study including 767 (494 men, 273 women) incident cases of RCC and 1,534 hospital controls, frequency-matched to cases. To estimate odds ratios and 95% confidence intervals, they used conditional logistic regression matched on study center, sex, and age and adjusted for period of interview, years of education, smoking habits, and family history of kidney cancer. Using body-size measurements taken 1 year prior to diagnosis/interview, the authors found an odds ratio of 1.3 (95% confidence interval (CI): 1.0, 1.7) among obese persons (body mass index (BMI; weight (kg)/height (m)(2)) > or =30) versus normal-weight persons (BMI <25) and an odds ratio of 1.5 (95% CI: 1.1, 2.0) among persons in the highest tertile of waist-to-hip ratio. Direct associations emerged for BMI > or =30 (vs. <25) at ages 30 years (odds ratio = 1.5, 95% CI: 1.0, 2.3) and 50 years (odds ratio = 1.5, 95% CI: 1.1, 2.0). The direct association with waist-to-hip ratio was stronger among women than among men. RCC risks among overweight and obese persons were apparently higher in never smokers, persons with the clear-cell histologic type, and persons with a Fuhrman nuclear grade of G3-G4.

Authors+Show Affiliations

S.O.C. Epidemiologia e Biostatistica, Centro di Riferimento Oncologico, Aviano (PN), Italy. epidemiology@cro.itNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17591592

Citation

Dal Maso, Luigino, et al. "Renal Cell Cancer and Body Size at Different Ages: an Italian Multicenter Case-control Study." American Journal of Epidemiology, vol. 166, no. 5, 2007, pp. 582-91.
Dal Maso L, Zucchetto A, Tavani A, et al. Renal cell cancer and body size at different ages: an Italian multicenter case-control study. Am J Epidemiol. 2007;166(5):582-91.
Dal Maso, L., Zucchetto, A., Tavani, A., Montella, M., Ramazzotti, V., Talamini, R., ... Franceschi, S. (2007). Renal cell cancer and body size at different ages: an Italian multicenter case-control study. American Journal of Epidemiology, 166(5), pp. 582-91.
Dal Maso L, et al. Renal Cell Cancer and Body Size at Different Ages: an Italian Multicenter Case-control Study. Am J Epidemiol. 2007 Sep 1;166(5):582-91. PubMed PMID: 17591592.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Renal cell cancer and body size at different ages: an Italian multicenter case-control study. AU - Dal Maso,Luigino, AU - Zucchetto,Antonella, AU - Tavani,Alessandra, AU - Montella,Maurizio, AU - Ramazzotti,Valerio, AU - Talamini,Renato, AU - Canzonieri,Vincenzo, AU - Garbeglio,Antonio, AU - Negri,Eva, AU - Tonini,Annamaria, AU - La Vecchia,Carlo, AU - Franceschi,Silvia, Y1 - 2007/06/24/ PY - 2007/6/27/pubmed PY - 2007/10/19/medline PY - 2007/6/27/entrez SP - 582 EP - 91 JF - American journal of epidemiology JO - Am. J. Epidemiol. VL - 166 IS - 5 N2 - An increased risk of renal cell cancer (RCC) has been reported in overweight persons. The authors aimed to clarify which anthropometric measures are associated with risk of RCC and whether risk may vary according to selected variables. Between 1992 and 2004, they carried out an Italian multicenter case-control study including 767 (494 men, 273 women) incident cases of RCC and 1,534 hospital controls, frequency-matched to cases. To estimate odds ratios and 95% confidence intervals, they used conditional logistic regression matched on study center, sex, and age and adjusted for period of interview, years of education, smoking habits, and family history of kidney cancer. Using body-size measurements taken 1 year prior to diagnosis/interview, the authors found an odds ratio of 1.3 (95% confidence interval (CI): 1.0, 1.7) among obese persons (body mass index (BMI; weight (kg)/height (m)(2)) > or =30) versus normal-weight persons (BMI <25) and an odds ratio of 1.5 (95% CI: 1.1, 2.0) among persons in the highest tertile of waist-to-hip ratio. Direct associations emerged for BMI > or =30 (vs. <25) at ages 30 years (odds ratio = 1.5, 95% CI: 1.0, 2.3) and 50 years (odds ratio = 1.5, 95% CI: 1.1, 2.0). The direct association with waist-to-hip ratio was stronger among women than among men. RCC risks among overweight and obese persons were apparently higher in never smokers, persons with the clear-cell histologic type, and persons with a Fuhrman nuclear grade of G3-G4. SN - 0002-9262 UR - https://www.unboundmedicine.com/medline/citation/17591592/Renal_cell_cancer_and_body_size_at_different_ages:_an_Italian_multicenter_case_control_study_ L2 - https://academic.oup.com/aje/article-lookup/doi/10.1093/aje/kwm108 DB - PRIME DP - Unbound Medicine ER -