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Evaluation of optical coherence tomography and heidelberg retinal tomography parameters in detecting early and moderate glaucoma.
Invest Ophthalmol Vis Sci. 2007 Jul; 48(7):3138-45.IO

Abstract

PURPOSE

To evaluate the relationship between optic nerve head (ONH) and peripapillary retinal nerve fiber layer (RNFL) parameters by optical coherence tomography (OCT) and confocal scanning laser ophthalmoscopy (Heidelberg retinal tomography; HRT; Heidelberg Engineering, Heidelberg, Germany) in early and moderate glaucoma and to compare several OCT-based automated classifiers with those inbuilt in HRT for detection of glaucomatous damage.

METHODS

This cross-sectional study included 60 eyes of 60 patients with glaucoma (30 early and 30 moderate visual field defects) and 60 eyes of 60 healthy subjects. All patients underwent Fast Optic Disc and Fast Peripapillary RNFL scans on the OCT and then HRT evaluation of the ONH during the same visit. Glaucoma variables obtained from OCT and HRT analyses were compared among the groups. Receiver operator characteristic (ROC) curves generated by performing linear discriminant analysis (LDA), artificial neural networks (ANNs), and classification and regression trees (CART) on OCT-based parameters were compared with the Moorfield regression analysis (MRA), R Bathija (RB), and FS Mickelberg (FSM) functions in the HRT, to classify eyes as either glaucomatous or normal.

RESULTS

No statistically significant difference was found in the disc area measured by the OCT and HRT analyses within each study group (P > 0.05). The areas under ROC curves were 0.9822 (LDF), 0.9791 (CART), and 0.9383 (ANN) as compared with 0.859 (FSM), 0.842 (RB) and 0.767 (MRA).

CONCLUSIONS

OCT-based automated classifiers performed better than HRT classifiers in distinguishing glaucomatous from healthy eyes. Such parameters should be integrated in the OCT to improve its diagnostic abilities.

Authors+Show Affiliations

Glaucoma Research Facility, Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India. drprashantnaithani@yahoo.co.inNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Evaluation Study
Journal Article

Language

eng

PubMed ID

17591883

Citation

Naithani, Prashant, et al. "Evaluation of Optical Coherence Tomography and Heidelberg Retinal Tomography Parameters in Detecting Early and Moderate Glaucoma." Investigative Ophthalmology & Visual Science, vol. 48, no. 7, 2007, pp. 3138-45.
Naithani P, Sihota R, Sony P, et al. Evaluation of optical coherence tomography and heidelberg retinal tomography parameters in detecting early and moderate glaucoma. Invest Ophthalmol Vis Sci. 2007;48(7):3138-45.
Naithani, P., Sihota, R., Sony, P., Dada, T., Gupta, V., Kondal, D., & Pandey, R. M. (2007). Evaluation of optical coherence tomography and heidelberg retinal tomography parameters in detecting early and moderate glaucoma. Investigative Ophthalmology & Visual Science, 48(7), 3138-45.
Naithani P, et al. Evaluation of Optical Coherence Tomography and Heidelberg Retinal Tomography Parameters in Detecting Early and Moderate Glaucoma. Invest Ophthalmol Vis Sci. 2007;48(7):3138-45. PubMed PMID: 17591883.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Evaluation of optical coherence tomography and heidelberg retinal tomography parameters in detecting early and moderate glaucoma. AU - Naithani,Prashant, AU - Sihota,Ramanjit, AU - Sony,Parul, AU - Dada,Tanuj, AU - Gupta,Viney, AU - Kondal,Dimple, AU - Pandey,Ravindra M, PY - 2007/6/27/pubmed PY - 2007/8/24/medline PY - 2007/6/27/entrez SP - 3138 EP - 45 JF - Investigative ophthalmology & visual science JO - Invest Ophthalmol Vis Sci VL - 48 IS - 7 N2 - PURPOSE: To evaluate the relationship between optic nerve head (ONH) and peripapillary retinal nerve fiber layer (RNFL) parameters by optical coherence tomography (OCT) and confocal scanning laser ophthalmoscopy (Heidelberg retinal tomography; HRT; Heidelberg Engineering, Heidelberg, Germany) in early and moderate glaucoma and to compare several OCT-based automated classifiers with those inbuilt in HRT for detection of glaucomatous damage. METHODS: This cross-sectional study included 60 eyes of 60 patients with glaucoma (30 early and 30 moderate visual field defects) and 60 eyes of 60 healthy subjects. All patients underwent Fast Optic Disc and Fast Peripapillary RNFL scans on the OCT and then HRT evaluation of the ONH during the same visit. Glaucoma variables obtained from OCT and HRT analyses were compared among the groups. Receiver operator characteristic (ROC) curves generated by performing linear discriminant analysis (LDA), artificial neural networks (ANNs), and classification and regression trees (CART) on OCT-based parameters were compared with the Moorfield regression analysis (MRA), R Bathija (RB), and FS Mickelberg (FSM) functions in the HRT, to classify eyes as either glaucomatous or normal. RESULTS: No statistically significant difference was found in the disc area measured by the OCT and HRT analyses within each study group (P > 0.05). The areas under ROC curves were 0.9822 (LDF), 0.9791 (CART), and 0.9383 (ANN) as compared with 0.859 (FSM), 0.842 (RB) and 0.767 (MRA). CONCLUSIONS: OCT-based automated classifiers performed better than HRT classifiers in distinguishing glaucomatous from healthy eyes. Such parameters should be integrated in the OCT to improve its diagnostic abilities. SN - 0146-0404 UR - https://www.unboundmedicine.com/medline/citation/17591883/Evaluation_of_optical_coherence_tomography_and_heidelberg_retinal_tomography_parameters_in_detecting_early_and_moderate_glaucoma_ L2 - https://iovs.arvojournals.org/article.aspx?doi=10.1167/iovs.06-1407 DB - PRIME DP - Unbound Medicine ER -