TY - JOUR T1 - Intake of added sugar and sugar-sweetened drink and serum uric acid concentration in US men and women. AU - Gao,Xiang, AU - Qi,Lu, AU - Qiao,Ning, AU - Choi,Hyon K, AU - Curhan,Gary, AU - Tucker,Katherine L, AU - Ascherio,Alberto, Y1 - 2007/06/25/ PY - 2007/6/27/pubmed PY - 2007/8/9/medline PY - 2007/6/27/entrez SP - 306 EP - 12 JF - Hypertension (Dallas, Tex. : 1979) JO - Hypertension VL - 50 IS - 2 N2 - Fructose-induced hyperuricemia might have a causal role in metabolic syndrome, hypertension, and other chronic disease. However, no study has investigated whether sugar added to foods or sugar-sweetened beverages, which are major sources of fructose, are associated with serum uric acid concentration in free-living populations. We examined the relationship between the intakes of added sugars and sugar-sweetened beverages and serum uric acid concentrations in the National Health and Nutrition Examination Survey 2001-2002, a nationally representative sample of men and women. We included 4073 subjects (1988 men and 2085 women) >18 years of age in the current study. Dietary intake was assessed by a single 24-hour recall. We used multivariate linear regression to adjust for age, gender, intake of energy and alcohol, body mass index, use of diuretics, beta-blockers, and other covariates. Male subjects in the highest intake quartile of estimated intake of added sugars or sugar-sweetened drinks had higher plasma uric acid concentrations than those in the lowest intake quartiles (P<0.001 for both) after adjusting for potential confounders, whereas we did not observe significant associations for females (P for trend>0.2; P for interaction <0.01). Further research is needed to confirm causality of these associations and the observed difference by gender. SN - 1524-4563 UR - https://www.unboundmedicine.com/medline/citation/17592072/Intake_of_added_sugar_and_sugar_sweetened_drink_and_serum_uric_acid_concentration_in_US_men_and_women_ DB - PRIME DP - Unbound Medicine ER -