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Use of antidepressants and rates of hip bone loss in older women: the study of osteoporotic fractures.
Arch Intern Med. 2007 Jun 25; 167(12):1240-5.AI

Abstract

BACKGROUND

Serotonin transporters have recently been described in bone, raising the possibility that medications that block serotonin reuptake could affect bone metabolism.

METHODS

We assessed current use of selective serotonin reuptake inhibitors (SSRIs) and tricyclic antidepressants (TCAs) and obtained serial bone mineral density (BMD) measurements in a cohort of 2722 older women (mean age, 78.5 years) participating in the Study of Osteoporotic Fractures, a prospective cohort study of community-dwelling women. Hip BMD was measured at the sixth examination and an average of 4.9 years later at the eighth examination. We categorized women as nonusers (used no SSRIs or TCAs at either examination; n=2406), SSRI users (used SSRIs but no TCAs at either examination; n=198), or TCA users (used TCAs but no SSRIs at either examination; n=118). Depressive symptoms were identified using a cutoff score of at least 6 on the Geriatric Depression Scale.

RESULTS

After adjustment for potential confounders, including the Geriatric Depression Scale score, mean total hip BMD decreased 0.47% per year in nonusers compared with 0.82% in SSRI users (P<.001) and 0.47% in TCA users (P=.99). Higher rates of bone loss were also observed at the 2 hip subregions for SSRI users. Results were not substantially altered when women who scored at least 6 on the Geriatric Depression Scale were excluded from the analysis.

CONCLUSION

Use of SSRIs but not TCAs is associated with an increased rate of bone loss at the hip in this cohort of older women.

Authors+Show Affiliations

Department of Medicine, University of Minnesota, and Center for Chronic Disease Outcomes Research, Minneapolis Veterans Affairs Medical Center, 1100 Washington Ave S, Suite 201, Minneapolis, MN 55415, USA. sdiem@umn.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

17592096

Citation

Diem, Susan J., et al. "Use of Antidepressants and Rates of Hip Bone Loss in Older Women: the Study of Osteoporotic Fractures." Archives of Internal Medicine, vol. 167, no. 12, 2007, pp. 1240-5.
Diem SJ, Blackwell TL, Stone KL, et al. Use of antidepressants and rates of hip bone loss in older women: the study of osteoporotic fractures. Arch Intern Med. 2007;167(12):1240-5.
Diem, S. J., Blackwell, T. L., Stone, K. L., Yaffe, K., Haney, E. M., Bliziotes, M. M., & Ensrud, K. E. (2007). Use of antidepressants and rates of hip bone loss in older women: the study of osteoporotic fractures. Archives of Internal Medicine, 167(12), 1240-5.
Diem SJ, et al. Use of Antidepressants and Rates of Hip Bone Loss in Older Women: the Study of Osteoporotic Fractures. Arch Intern Med. 2007 Jun 25;167(12):1240-5. PubMed PMID: 17592096.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Use of antidepressants and rates of hip bone loss in older women: the study of osteoporotic fractures. AU - Diem,Susan J, AU - Blackwell,Terri L, AU - Stone,Katie L, AU - Yaffe,Kristine, AU - Haney,Elizabeth M, AU - Bliziotes,Michael M, AU - Ensrud,Kristine E, PY - 2007/6/27/pubmed PY - 2007/8/19/medline PY - 2007/6/27/entrez SP - 1240 EP - 5 JF - Archives of internal medicine JO - Arch. Intern. Med. VL - 167 IS - 12 N2 - BACKGROUND: Serotonin transporters have recently been described in bone, raising the possibility that medications that block serotonin reuptake could affect bone metabolism. METHODS: We assessed current use of selective serotonin reuptake inhibitors (SSRIs) and tricyclic antidepressants (TCAs) and obtained serial bone mineral density (BMD) measurements in a cohort of 2722 older women (mean age, 78.5 years) participating in the Study of Osteoporotic Fractures, a prospective cohort study of community-dwelling women. Hip BMD was measured at the sixth examination and an average of 4.9 years later at the eighth examination. We categorized women as nonusers (used no SSRIs or TCAs at either examination; n=2406), SSRI users (used SSRIs but no TCAs at either examination; n=198), or TCA users (used TCAs but no SSRIs at either examination; n=118). Depressive symptoms were identified using a cutoff score of at least 6 on the Geriatric Depression Scale. RESULTS: After adjustment for potential confounders, including the Geriatric Depression Scale score, mean total hip BMD decreased 0.47% per year in nonusers compared with 0.82% in SSRI users (P<.001) and 0.47% in TCA users (P=.99). Higher rates of bone loss were also observed at the 2 hip subregions for SSRI users. Results were not substantially altered when women who scored at least 6 on the Geriatric Depression Scale were excluded from the analysis. CONCLUSION: Use of SSRIs but not TCAs is associated with an increased rate of bone loss at the hip in this cohort of older women. SN - 0003-9926 UR - https://www.unboundmedicine.com/medline/citation/17592096/Use_of_antidepressants_and_rates_of_hip_bone_loss_in_older_women:_the_study_of_osteoporotic_fractures_ L2 - https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/10.1001/archinte.167.12.1240 DB - PRIME DP - Unbound Medicine ER -