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Women and celiac disease: association with unexplained infertility.
Minerva Med 2007; 98(3):217-9MM

Abstract

Celiac disease (CD) is a permanent intolerance to gluten characterized by destructions of the small intestinal villi and malabsorption. The gluten-free diet (GFD) results in healing of the mucosa, resolution of the malabsorpitive states, and reversal of great part of CD effects. Among the extradigestive complications associated with CD, unexplained infertility has been reported since the 70's. The prevalence of CD among women with unexplained infertility is 2.5-3.5%, higher, although not always significantly, than control population. To date, it is widely accepted that untreated CD represents a risk for abortion, low birth weight babies and short-breast feeding period. These features can be corrected by GFD. Some discrepancies could stem from the heterogeneity of the studies. Regarding a potential pathogenic mechanism, since CD causes malabsorption of folic acid and other nutrients, this pathway has been proposed to explain the unfavourable outcomes of pregnancy. However, this remains a speculation. In conclusion, each woman with unexplained infertility should be screened for CD.

Authors+Show Affiliations

Department of Gastro-Hepatology, Molinette Hospital, Turin, Italy. rinaldo_pellican@hotmail.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article
Review

Language

eng

PubMed ID

17592443

Citation

Pellicano, R, et al. "Women and Celiac Disease: Association With Unexplained Infertility." Minerva Medica, vol. 98, no. 3, 2007, pp. 217-9.
Pellicano R, Astegiano M, Bruno M, et al. Women and celiac disease: association with unexplained infertility. Minerva Med. 2007;98(3):217-9.
Pellicano, R., Astegiano, M., Bruno, M., Fagoonee, S., & Rizzetto, M. (2007). Women and celiac disease: association with unexplained infertility. Minerva Medica, 98(3), pp. 217-9.
Pellicano R, et al. Women and Celiac Disease: Association With Unexplained Infertility. Minerva Med. 2007;98(3):217-9. PubMed PMID: 17592443.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Women and celiac disease: association with unexplained infertility. AU - Pellicano,R, AU - Astegiano,M, AU - Bruno,M, AU - Fagoonee,S, AU - Rizzetto,M, PY - 2007/6/27/pubmed PY - 2007/12/6/medline PY - 2007/6/27/entrez SP - 217 EP - 9 JF - Minerva medica JO - Minerva Med. VL - 98 IS - 3 N2 - Celiac disease (CD) is a permanent intolerance to gluten characterized by destructions of the small intestinal villi and malabsorption. The gluten-free diet (GFD) results in healing of the mucosa, resolution of the malabsorpitive states, and reversal of great part of CD effects. Among the extradigestive complications associated with CD, unexplained infertility has been reported since the 70's. The prevalence of CD among women with unexplained infertility is 2.5-3.5%, higher, although not always significantly, than control population. To date, it is widely accepted that untreated CD represents a risk for abortion, low birth weight babies and short-breast feeding period. These features can be corrected by GFD. Some discrepancies could stem from the heterogeneity of the studies. Regarding a potential pathogenic mechanism, since CD causes malabsorption of folic acid and other nutrients, this pathway has been proposed to explain the unfavourable outcomes of pregnancy. However, this remains a speculation. In conclusion, each woman with unexplained infertility should be screened for CD. SN - 0026-4806 UR - https://www.unboundmedicine.com/medline/citation/17592443/Women_and_celiac_disease:_association_with_unexplained_infertility_ L2 - http://www.diseaseinfosearch.org/result/1186 DB - PRIME DP - Unbound Medicine ER -