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Metabolic syndrome is not associated with markers of subclinical atherosclerosis, serum adiponectin and endogenous androgen concentrations in Japanese men with Type 2 diabetes.
Diabet Med. 2007 Aug; 24(8):864-71.DM

Abstract

AIMS

Metabolic syndrome is characterized by its association with certain cardiovascular disease risk factors. The aim of this study was to investigate the relationships between metabolic syndrome and markers of subclinical atherosclerosis, serum adiponectin and endogenous androgen concentrations in Japanese men with Type 2 diabetes.

METHODS

Using the 2005 International Diabetes Federation (IDF) definition, we assessed the prevalence of the metabolic syndrome in 424 consecutive men with Type 2 diabetes aged 40-75 years in a cross-sectional study. We compared characteristics including ultrasonographic carotid atherosclerosis markers, pulse-wave velocity (PWV), and serum adiponectin, free testosterone, and dehydroepiandrosterone sulphate (DHEA-S) concentrations in diabetic patients with and without the metabolic syndrome.

RESULTS

The prevalence of the metabolic syndrome in Japanese men with Type 2 diabetes was 46.9%. Men with the metabolic syndrome had higher urinary albumin excretion rate than those without. Carotid intima-media thickness (0.97 +/- 0.26 vs. 0.91 +/- 0.18 mm), plaque score [3.3 (1.5-8.1) vs. 3.8 (1.3-6.2)], PWV (1818 +/- 331 vs. 1749 +/- 331 cm/s) and ankle-brachial index (1.10 +/- 0.14 vs. 1.08 +/- 0.16) did not differ significantly between patients with and without the metabolic syndrome. Similarly, serum adiponectin [3.70 (2.06-6.09) vs. 4.65 (3.09-7.02) microg/ml], free testosterone (36.4 +/- 10.7 vs. 34.7 +/- 11.1 pmol/l), and DHEA-S concentrations (3.29 +/- 1.83 vs. 3.17 +/- 1.63 micromol/l) did not differ significantly between groups,

CONCLUSIONS

The metabolic syndrome, as defined by the IDF, is not significantly associated with subclinical atherosclerosis markers, serum adiponectin, or endogenous androgen concentrations in Japanese men with Type 2 diabetes.

Authors+Show Affiliations

Department of Endocrinology and Metabolism, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Kyoto, Japan. sayarinapm@hotmail.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study

Language

eng

PubMed ID

17593243

Citation

Fukui, M, et al. "Metabolic Syndrome Is Not Associated With Markers of Subclinical Atherosclerosis, Serum Adiponectin and Endogenous Androgen Concentrations in Japanese Men With Type 2 Diabetes." Diabetic Medicine : a Journal of the British Diabetic Association, vol. 24, no. 8, 2007, pp. 864-71.
Fukui M, Ose H, Kitagawa Y, et al. Metabolic syndrome is not associated with markers of subclinical atherosclerosis, serum adiponectin and endogenous androgen concentrations in Japanese men with Type 2 diabetes. Diabet Med. 2007;24(8):864-71.
Fukui, M., Ose, H., Kitagawa, Y., Kamiuchi, K., Nakayama, I., Ohta, M., Obayashi, H., Yamasaki, M., Hasegawa, G., Yoshikawa, T., & Nakamura, N. (2007). Metabolic syndrome is not associated with markers of subclinical atherosclerosis, serum adiponectin and endogenous androgen concentrations in Japanese men with Type 2 diabetes. Diabetic Medicine : a Journal of the British Diabetic Association, 24(8), 864-71.
Fukui M, et al. Metabolic Syndrome Is Not Associated With Markers of Subclinical Atherosclerosis, Serum Adiponectin and Endogenous Androgen Concentrations in Japanese Men With Type 2 Diabetes. Diabet Med. 2007;24(8):864-71. PubMed PMID: 17593243.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Metabolic syndrome is not associated with markers of subclinical atherosclerosis, serum adiponectin and endogenous androgen concentrations in Japanese men with Type 2 diabetes. AU - Fukui,M, AU - Ose,H, AU - Kitagawa,Y, AU - Kamiuchi,K, AU - Nakayama,I, AU - Ohta,M, AU - Obayashi,H, AU - Yamasaki,M, AU - Hasegawa,G, AU - Yoshikawa,T, AU - Nakamura,N, Y1 - 2007/06/25/ PY - 2007/6/27/pubmed PY - 2007/11/10/medline PY - 2007/6/27/entrez SP - 864 EP - 71 JF - Diabetic medicine : a journal of the British Diabetic Association JO - Diabet Med VL - 24 IS - 8 N2 - AIMS: Metabolic syndrome is characterized by its association with certain cardiovascular disease risk factors. The aim of this study was to investigate the relationships between metabolic syndrome and markers of subclinical atherosclerosis, serum adiponectin and endogenous androgen concentrations in Japanese men with Type 2 diabetes. METHODS: Using the 2005 International Diabetes Federation (IDF) definition, we assessed the prevalence of the metabolic syndrome in 424 consecutive men with Type 2 diabetes aged 40-75 years in a cross-sectional study. We compared characteristics including ultrasonographic carotid atherosclerosis markers, pulse-wave velocity (PWV), and serum adiponectin, free testosterone, and dehydroepiandrosterone sulphate (DHEA-S) concentrations in diabetic patients with and without the metabolic syndrome. RESULTS: The prevalence of the metabolic syndrome in Japanese men with Type 2 diabetes was 46.9%. Men with the metabolic syndrome had higher urinary albumin excretion rate than those without. Carotid intima-media thickness (0.97 +/- 0.26 vs. 0.91 +/- 0.18 mm), plaque score [3.3 (1.5-8.1) vs. 3.8 (1.3-6.2)], PWV (1818 +/- 331 vs. 1749 +/- 331 cm/s) and ankle-brachial index (1.10 +/- 0.14 vs. 1.08 +/- 0.16) did not differ significantly between patients with and without the metabolic syndrome. Similarly, serum adiponectin [3.70 (2.06-6.09) vs. 4.65 (3.09-7.02) microg/ml], free testosterone (36.4 +/- 10.7 vs. 34.7 +/- 11.1 pmol/l), and DHEA-S concentrations (3.29 +/- 1.83 vs. 3.17 +/- 1.63 micromol/l) did not differ significantly between groups, CONCLUSIONS: The metabolic syndrome, as defined by the IDF, is not significantly associated with subclinical atherosclerosis markers, serum adiponectin, or endogenous androgen concentrations in Japanese men with Type 2 diabetes. SN - 0742-3071 UR - https://www.unboundmedicine.com/medline/citation/17593243/Metabolic_syndrome_is_not_associated_with_markers_of_subclinical_atherosclerosis_serum_adiponectin_and_endogenous_androgen_concentrations_in_Japanese_men_with_Type_2_diabetes_ L2 - https://doi.org/10.1111/j.1464-5491.2007.02213.x DB - PRIME DP - Unbound Medicine ER -