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Serum C3 is a stronger inflammatory marker of insulin resistance than C-reactive protein, leukocyte count, and erythrocyte sedimentation rate: comparison study in an elderly population.
Diabetes Care. 2007 Sep; 30(9):2362-8.DC

Abstract

OBJECTIVE

This study was performed to ascertain the relative relevance of some inflammatory markers in insulin resistance.

RESEARCH DESIGN AND METHODS

Four inflammatory markers (leukocyte count, erythrocyte sedimentation rate [ESR], high-sensitivity C-reactive protein [CRP], and C3 complement) were assessed as possible determinants of the homeostasis model assessment (HOMA) index, together with the five elements of the metabolic syndrome (National Cholesterol Education Program Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults [Adult Treatment Panel III] definition), total cholesterol, physical activity, and four indicators of adiposity (BMI, waist circumference, percent body fat, and hepatic steatosis) in an unselected population of 990 subjects aged 65-91 years (the Pianoro Study).

RESULTS

In univariable analysis, C3, CRP, and leukocyte count, but not ESR, were significantly correlated with HOMA index. In multivariable analysis, C3 remained associated with insulin resistance with the highest partial R(2) value (0.049), independently of all other covariates. The other most significant (P < 0.0001) determinants of HOMA index were total cholesterol (inverse association, R(2) = 0.026), waist circumference (R(2) = 0.023), triglycerides (R(2) = 0.022), and hepatic steatosis (R(2) = 0.021) (R(2) = 0.450 for the whole model). The adjusted relative risks of having the metabolic syndrome for the subjects with inflammatory markers in the high tertile, with respect to those with lower values, were (prevalence ratio [95% CI]): 1.77 (1.41-2.22) for C3, 1.38 (1.12-1.70) for leukocyte count, 1.17 (0.94-1.46) for CRP, and 1.13 (0.91-1.40) for ESR.

CONCLUSIONS

Of the four inflammatory markers simultaneously assessed in our elderly population, only C3 was strongly associated with insulin resistance, independently of the components of the metabolic syndrome and the main indexes of abdominal and general obesity.

Authors+Show Affiliations

Department of Internal Medicine, Cardioangiology, and Hepatology, University of Bologna, Bologna, Italy. amuscari@med.unibo.itNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17595349

Citation

Muscari, Antonio, et al. "Serum C3 Is a Stronger Inflammatory Marker of Insulin Resistance Than C-reactive Protein, Leukocyte Count, and Erythrocyte Sedimentation Rate: Comparison Study in an Elderly Population." Diabetes Care, vol. 30, no. 9, 2007, pp. 2362-8.
Muscari A, Antonelli S, Bianchi G, et al. Serum C3 is a stronger inflammatory marker of insulin resistance than C-reactive protein, leukocyte count, and erythrocyte sedimentation rate: comparison study in an elderly population. Diabetes Care. 2007;30(9):2362-8.
Muscari, A., Antonelli, S., Bianchi, G., Cavrini, G., Dapporto, S., Ligabue, A., Ludovico, C., Magalotti, D., Poggiopollini, G., & Zoli, M. (2007). Serum C3 is a stronger inflammatory marker of insulin resistance than C-reactive protein, leukocyte count, and erythrocyte sedimentation rate: comparison study in an elderly population. Diabetes Care, 30(9), 2362-8.
Muscari A, et al. Serum C3 Is a Stronger Inflammatory Marker of Insulin Resistance Than C-reactive Protein, Leukocyte Count, and Erythrocyte Sedimentation Rate: Comparison Study in an Elderly Population. Diabetes Care. 2007;30(9):2362-8. PubMed PMID: 17595349.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Serum C3 is a stronger inflammatory marker of insulin resistance than C-reactive protein, leukocyte count, and erythrocyte sedimentation rate: comparison study in an elderly population. AU - Muscari,Antonio, AU - Antonelli,Serafina, AU - Bianchi,Giampaolo, AU - Cavrini,Giulia, AU - Dapporto,Susanna, AU - Ligabue,Amedeo, AU - Ludovico,Cosimo, AU - Magalotti,Donatella, AU - Poggiopollini,Guido, AU - Zoli,Marco, AU - ,, Y1 - 2007/06/26/ PY - 2007/6/28/pubmed PY - 2007/9/7/medline PY - 2007/6/28/entrez SP - 2362 EP - 8 JF - Diabetes care JO - Diabetes Care VL - 30 IS - 9 N2 - OBJECTIVE: This study was performed to ascertain the relative relevance of some inflammatory markers in insulin resistance. RESEARCH DESIGN AND METHODS: Four inflammatory markers (leukocyte count, erythrocyte sedimentation rate [ESR], high-sensitivity C-reactive protein [CRP], and C3 complement) were assessed as possible determinants of the homeostasis model assessment (HOMA) index, together with the five elements of the metabolic syndrome (National Cholesterol Education Program Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults [Adult Treatment Panel III] definition), total cholesterol, physical activity, and four indicators of adiposity (BMI, waist circumference, percent body fat, and hepatic steatosis) in an unselected population of 990 subjects aged 65-91 years (the Pianoro Study). RESULTS: In univariable analysis, C3, CRP, and leukocyte count, but not ESR, were significantly correlated with HOMA index. In multivariable analysis, C3 remained associated with insulin resistance with the highest partial R(2) value (0.049), independently of all other covariates. The other most significant (P < 0.0001) determinants of HOMA index were total cholesterol (inverse association, R(2) = 0.026), waist circumference (R(2) = 0.023), triglycerides (R(2) = 0.022), and hepatic steatosis (R(2) = 0.021) (R(2) = 0.450 for the whole model). The adjusted relative risks of having the metabolic syndrome for the subjects with inflammatory markers in the high tertile, with respect to those with lower values, were (prevalence ratio [95% CI]): 1.77 (1.41-2.22) for C3, 1.38 (1.12-1.70) for leukocyte count, 1.17 (0.94-1.46) for CRP, and 1.13 (0.91-1.40) for ESR. CONCLUSIONS: Of the four inflammatory markers simultaneously assessed in our elderly population, only C3 was strongly associated with insulin resistance, independently of the components of the metabolic syndrome and the main indexes of abdominal and general obesity. SN - 1935-5548 UR - https://www.unboundmedicine.com/medline/citation/17595349/Serum_C3_is_a_stronger_inflammatory_marker_of_insulin_resistance_than_C_reactive_protein_leukocyte_count_and_erythrocyte_sedimentation_rate:_comparison_study_in_an_elderly_population_ L2 - http://care.diabetesjournals.org/cgi/pmidlookup?view=long&amp;pmid=17595349 DB - PRIME DP - Unbound Medicine ER -