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Inter-relationships of interleukin-6, cardiovascular risk factors and the metabolic syndrome among older men.
J Thromb Haemost. 2007 Aug; 5(8):1637-43.JT

Abstract

OBJECTIVES

Interleukin-6 (IL-6) has been implicated in the development of cardiovascular disease. We have examined the relationship between plasma IL-6 and insulin resistance, and metabolic, inflammatory and hemostatic markers.

METHODS

We examined 3490 men aged 60-79 years who were drawn from general practices in 24 British towns. The men were not diabetic and were not taking warfarin.

RESULTS

IL-6 was significantly associated with age, body mass index (BMI), waist circumference (WC), cigarette smoking, low physical activity, social class and alcohol intake (U-shaped). IL-6 showed no association with insulin resistance or its other components (blood glucose, triglycerides, blood pressure) except high-density lipoprotein-cholesterol (inversely), and no association with hematocrit, factor (F) VII or adiponectin after adjustment for age and WC. IL-6 was strongly associated with markers of inflammation (C-reactive protein, fibrinogen, white cell count); plasma viscosity; elevated markers of coagulation (fibrin D-dimer, FVIII, FIX); markers of endothelial dysfunction (von Willebrand factor, tissue plasminogen activator); and to a smaller extent with platelet count, APC ratio and gamma glutamyltransferase. Risk of the metabolic syndrome increased significantly with increasing IL-6 but was attenuated after adjustment for BMI.

CONCLUSION

IL-6 may have a potential role as a mediator between cardiovascular risk factors and several biological mechanisms for cardiovascular disease.

Authors+Show Affiliations

Department of Primary Care and Population Sciences, Royal Free and University College Medical School, London, UK. goya@pcps.ucl.ac.ukNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17596140

Citation

Wannamethee, S G., et al. "Inter-relationships of Interleukin-6, Cardiovascular Risk Factors and the Metabolic Syndrome Among Older Men." Journal of Thrombosis and Haemostasis : JTH, vol. 5, no. 8, 2007, pp. 1637-43.
Wannamethee SG, Whincup PH, Rumley A, et al. Inter-relationships of interleukin-6, cardiovascular risk factors and the metabolic syndrome among older men. J Thromb Haemost. 2007;5(8):1637-43.
Wannamethee, S. G., Whincup, P. H., Rumley, A., & Lowe, G. D. (2007). Inter-relationships of interleukin-6, cardiovascular risk factors and the metabolic syndrome among older men. Journal of Thrombosis and Haemostasis : JTH, 5(8), 1637-43.
Wannamethee SG, et al. Inter-relationships of Interleukin-6, Cardiovascular Risk Factors and the Metabolic Syndrome Among Older Men. J Thromb Haemost. 2007;5(8):1637-43. PubMed PMID: 17596140.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Inter-relationships of interleukin-6, cardiovascular risk factors and the metabolic syndrome among older men. AU - Wannamethee,S G, AU - Whincup,P H, AU - Rumley,A, AU - Lowe,G D O, Y1 - 2007/06/01/ PY - 2007/6/29/pubmed PY - 2007/9/28/medline PY - 2007/6/29/entrez SP - 1637 EP - 43 JF - Journal of thrombosis and haemostasis : JTH JO - J Thromb Haemost VL - 5 IS - 8 N2 - OBJECTIVES: Interleukin-6 (IL-6) has been implicated in the development of cardiovascular disease. We have examined the relationship between plasma IL-6 and insulin resistance, and metabolic, inflammatory and hemostatic markers. METHODS: We examined 3490 men aged 60-79 years who were drawn from general practices in 24 British towns. The men were not diabetic and were not taking warfarin. RESULTS: IL-6 was significantly associated with age, body mass index (BMI), waist circumference (WC), cigarette smoking, low physical activity, social class and alcohol intake (U-shaped). IL-6 showed no association with insulin resistance or its other components (blood glucose, triglycerides, blood pressure) except high-density lipoprotein-cholesterol (inversely), and no association with hematocrit, factor (F) VII or adiponectin after adjustment for age and WC. IL-6 was strongly associated with markers of inflammation (C-reactive protein, fibrinogen, white cell count); plasma viscosity; elevated markers of coagulation (fibrin D-dimer, FVIII, FIX); markers of endothelial dysfunction (von Willebrand factor, tissue plasminogen activator); and to a smaller extent with platelet count, APC ratio and gamma glutamyltransferase. Risk of the metabolic syndrome increased significantly with increasing IL-6 but was attenuated after adjustment for BMI. CONCLUSION: IL-6 may have a potential role as a mediator between cardiovascular risk factors and several biological mechanisms for cardiovascular disease. SN - 1538-7933 UR - https://www.unboundmedicine.com/medline/citation/17596140/Inter_relationships_of_interleukin_6_cardiovascular_risk_factors_and_the_metabolic_syndrome_among_older_men_ L2 - https://doi.org/10.1111/j.1538-7836.2007.02643.x DB - PRIME DP - Unbound Medicine ER -