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A study of the secretion mechanism of the sebaceous gland using three-dimensional reconstruction to examine the morphological relationship between the sebaceous gland and the arrector pili muscle in the follicular unit.
Br J Dermatol. 2007 Aug; 157(2):325-30.BJ

Abstract

BACKGROUND

New models of the structural relationship between the arrector pili (AP) muscle and the sebaceous gland (SG) have been proposed recently.

OBJECTIVES

The purpose of the present study was to establish the actual morphological relationship between components of the follicular unit (FU) including the hair follicles, AP muscle and SG using 3D reconstruction of serially sectioned specimens so as to expand previous explanations of the secretory mechanism of the SG and to suggest other possible mechanisms based on newly proposed model.

METHODS

Scalp skin specimens were processed using routine histological procedures, with serially sectioned tissue slides being stained with Masson's trichrome. 'Reconstruct' software was used to align, assemble and reconstruct the sections, with observations of the 3D-reconstructed FU [including hair follicles (HFs), AP muscle and SG].

RESULTS

Fifty FUs were reconstructed. The AP muscle was curved and concave as it supported the basal portion of the sebaceous lobules in the perifolliculum. Sebaceous lobules were located between the AP muscle and HFs (angular area) and some sebaceous lobules located in the opposite (counter-angular) area.

CONCLUSIONS

We propose that the concave part of the AP muscle pushes up the basal portion of the sebaceous lobule between the HFs and AP muscle during AP muscle contraction and hair erection. In addition, the sebaceous lobule located at the counter-angular position is squeezed by the HF during AP muscle relaxation and hair repositioning. Combined with the previous mechanism of SG secretion, this newly established mechanism based on the 3D structure of the FU will improve our understanding of AP muscle function and SG secretion.

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Authors+Show Affiliations

Song WC
Department of Anatomy, College of Medicine, Konkuk University, 322 Danwol-dong, Chungju, Chungbuk, 380-701, Republic of Korea.
Hu KS
No affiliation info available
Kim HJ
No affiliation info available
Koh KS
No affiliation info available

MeSH

AdultHair FollicleHumansImage Processing, Computer-AssistedModels, AnatomicMuscle ContractionMuscle RelaxationMuscle, SmoothScalpSebaceous Glands

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17596168

Citation

Song, W-C, et al. "A Study of the Secretion Mechanism of the Sebaceous Gland Using Three-dimensional Reconstruction to Examine the Morphological Relationship Between the Sebaceous Gland and the Arrector Pili Muscle in the Follicular Unit." The British Journal of Dermatology, vol. 157, no. 2, 2007, pp. 325-30.
Song WC, Hu KS, Kim HJ, et al. A study of the secretion mechanism of the sebaceous gland using three-dimensional reconstruction to examine the morphological relationship between the sebaceous gland and the arrector pili muscle in the follicular unit. Br J Dermatol. 2007;157(2):325-30.
Song, W. C., Hu, K. S., Kim, H. J., & Koh, K. S. (2007). A study of the secretion mechanism of the sebaceous gland using three-dimensional reconstruction to examine the morphological relationship between the sebaceous gland and the arrector pili muscle in the follicular unit. The British Journal of Dermatology, 157(2), 325-30.
Song WC, et al. A Study of the Secretion Mechanism of the Sebaceous Gland Using Three-dimensional Reconstruction to Examine the Morphological Relationship Between the Sebaceous Gland and the Arrector Pili Muscle in the Follicular Unit. Br J Dermatol. 2007;157(2):325-30. PubMed PMID: 17596168.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A study of the secretion mechanism of the sebaceous gland using three-dimensional reconstruction to examine the morphological relationship between the sebaceous gland and the arrector pili muscle in the follicular unit. AU - Song,W-C, AU - Hu,K-S, AU - Kim,H-J, AU - Koh,K-S, Y1 - 2007/06/26/ PY - 2007/6/29/pubmed PY - 2007/11/14/medline PY - 2007/6/29/entrez SP - 325 EP - 30 JF - The British journal of dermatology JO - Br J Dermatol VL - 157 IS - 2 N2 - BACKGROUND: New models of the structural relationship between the arrector pili (AP) muscle and the sebaceous gland (SG) have been proposed recently. OBJECTIVES: The purpose of the present study was to establish the actual morphological relationship between components of the follicular unit (FU) including the hair follicles, AP muscle and SG using 3D reconstruction of serially sectioned specimens so as to expand previous explanations of the secretory mechanism of the SG and to suggest other possible mechanisms based on newly proposed model. METHODS: Scalp skin specimens were processed using routine histological procedures, with serially sectioned tissue slides being stained with Masson's trichrome. 'Reconstruct' software was used to align, assemble and reconstruct the sections, with observations of the 3D-reconstructed FU [including hair follicles (HFs), AP muscle and SG]. RESULTS: Fifty FUs were reconstructed. The AP muscle was curved and concave as it supported the basal portion of the sebaceous lobules in the perifolliculum. Sebaceous lobules were located between the AP muscle and HFs (angular area) and some sebaceous lobules located in the opposite (counter-angular) area. CONCLUSIONS: We propose that the concave part of the AP muscle pushes up the basal portion of the sebaceous lobule between the HFs and AP muscle during AP muscle contraction and hair erection. In addition, the sebaceous lobule located at the counter-angular position is squeezed by the HF during AP muscle relaxation and hair repositioning. Combined with the previous mechanism of SG secretion, this newly established mechanism based on the 3D structure of the FU will improve our understanding of AP muscle function and SG secretion. SN - 0007-0963 UR - https://www.unboundmedicine.com/medline/citation/17596168/A_study_of_the_secretion_mechanism_of_the_sebaceous_gland_using_three_dimensional_reconstruction_to_examine_the_morphological_relationship_between_the_sebaceous_gland_and_the_arrector_pili_muscle_in_the_follicular_unit_ L2 - https://doi.org/10.1111/j.1365-2133.2007.08036.x DB - PRIME DP - Unbound Medicine ER -