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Alcohol, smoking, and body size in relation to incident Hodgkin's and non-Hodgkin's lymphoma risk.

Abstract

Studies associate alcohol consumption, cigarette smoking, and body size with the risk of overall or subtype lymphoma. Current data come mostly from case-control studies or prospective studies with few cases. In the prospective National Institutes of Health-former American Association of Retired Persons (NIH-AARP) Diet and Health Study, the authors assessed the above lifestyle factors via baseline questionnaire among 285,079 men and 188,905 women aged 50-71 years and ascertained histologically confirmed Hodgkin's lymphoma (n = 58) and non-Hodgkin's lymphoma (n = 1,381) cases through linkage with cancer registries from 1995 to 2000. Compared with nondrinkers, alcohol consumers had a lower risk for non-Hodgkin's lymphoma overall (for >28 drinks/week: adjusted relative risk (RR) = 0.77, 95% confidence interval (CI): 0.59, 1.00; p(trend) among drinkers = 0.02) and for its main subtypes. Compared with never smokers, current smokers and recent quitters (<or=4 years ago) had higher risk of Hodgkin's lymphoma (RR = 2.25, 95% CI: 1.04, 4.89; RR = 4.20, 95% CI: 1.94, 9.09, respectively), whereas current or former smokers had lower risk of follicular non-Hodgkin's lymphoma (RR = 0.67, 95% CI: 0.52, 0.86). Severe obesity (body mass index of >or=35: RR = 1.29, 95% CI: 1.02, 1.64) and taller height (RR = 1.19, 95% CI: 1.03, 1.38) were associated moderately with non-Hodgkin's lymphoma. These findings add to the evidence that lifestyle factors and relevant anthropometric characteristics play a role in lymphoma etiology.

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  • Authors+Show Affiliations

    ,

    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, MD 20852, USA. limu@mail.nih.gov

    , , , , , , , , ,

    Source

    American journal of epidemiology 166:6 2007 Sep 15 pg 697-708

    MeSH

    Aged
    Alcohol Drinking
    Anthropometry
    Body Size
    Chi-Square Distribution
    Female
    Hodgkin Disease
    Humans
    Incidence
    Lymphoma, Non-Hodgkin
    Male
    Middle Aged
    Proportional Hazards Models
    Prospective Studies
    SEER Program
    Smoking
    Surveys and Questionnaires
    United States

    Pub Type(s)

    Journal Article
    Research Support, N.I.H., Intramural

    Language

    eng

    PubMed ID

    17596266

    Citation

    Lim, Unhee, et al. "Alcohol, Smoking, and Body Size in Relation to Incident Hodgkin's and non-Hodgkin's Lymphoma Risk." American Journal of Epidemiology, vol. 166, no. 6, 2007, pp. 697-708.
    Lim U, Morton LM, Subar AF, et al. Alcohol, smoking, and body size in relation to incident Hodgkin's and non-Hodgkin's lymphoma risk. Am J Epidemiol. 2007;166(6):697-708.
    Lim, U., Morton, L. M., Subar, A. F., Baris, D., Stolzenberg-Solomon, R., Leitzmann, M., ... Hartge, P. (2007). Alcohol, smoking, and body size in relation to incident Hodgkin's and non-Hodgkin's lymphoma risk. American Journal of Epidemiology, 166(6), pp. 697-708.
    Lim U, et al. Alcohol, Smoking, and Body Size in Relation to Incident Hodgkin's and non-Hodgkin's Lymphoma Risk. Am J Epidemiol. 2007 Sep 15;166(6):697-708. PubMed PMID: 17596266.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Alcohol, smoking, and body size in relation to incident Hodgkin's and non-Hodgkin's lymphoma risk. AU - Lim,Unhee, AU - Morton,Lindsay M, AU - Subar,Amy F, AU - Baris,Dalsu, AU - Stolzenberg-Solomon,Rachael, AU - Leitzmann,Michael, AU - Kipnis,Victor, AU - Mouw,Traci, AU - Carroll,Leslie, AU - Schatzkin,Arthur, AU - Hartge,Patricia, Y1 - 2007/06/27/ PY - 2007/6/29/pubmed PY - 2007/10/19/medline PY - 2007/6/29/entrez SP - 697 EP - 708 JF - American journal of epidemiology JO - Am. J. Epidemiol. VL - 166 IS - 6 N2 - Studies associate alcohol consumption, cigarette smoking, and body size with the risk of overall or subtype lymphoma. Current data come mostly from case-control studies or prospective studies with few cases. In the prospective National Institutes of Health-former American Association of Retired Persons (NIH-AARP) Diet and Health Study, the authors assessed the above lifestyle factors via baseline questionnaire among 285,079 men and 188,905 women aged 50-71 years and ascertained histologically confirmed Hodgkin's lymphoma (n = 58) and non-Hodgkin's lymphoma (n = 1,381) cases through linkage with cancer registries from 1995 to 2000. Compared with nondrinkers, alcohol consumers had a lower risk for non-Hodgkin's lymphoma overall (for >28 drinks/week: adjusted relative risk (RR) = 0.77, 95% confidence interval (CI): 0.59, 1.00; p(trend) among drinkers = 0.02) and for its main subtypes. Compared with never smokers, current smokers and recent quitters (<or=4 years ago) had higher risk of Hodgkin's lymphoma (RR = 2.25, 95% CI: 1.04, 4.89; RR = 4.20, 95% CI: 1.94, 9.09, respectively), whereas current or former smokers had lower risk of follicular non-Hodgkin's lymphoma (RR = 0.67, 95% CI: 0.52, 0.86). Severe obesity (body mass index of >or=35: RR = 1.29, 95% CI: 1.02, 1.64) and taller height (RR = 1.19, 95% CI: 1.03, 1.38) were associated moderately with non-Hodgkin's lymphoma. These findings add to the evidence that lifestyle factors and relevant anthropometric characteristics play a role in lymphoma etiology. SN - 0002-9262 UR - https://www.unboundmedicine.com/medline/citation/17596266/Alcohol_smoking_and_body_size_in_relation_to_incident_Hodgkin's_and_non_Hodgkin's_lymphoma_risk_ L2 - https://academic.oup.com/aje/article-lookup/doi/10.1093/aje/kwm122 DB - PRIME DP - Unbound Medicine ER -