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Peptide YY, cholecystokinin, insulin and ghrelin response to meal did not change, but mean serum levels of insulin is reduced in children with Prader-Willi syndrome.
J Korean Med Sci 2007; 22(3):436-41JK

Abstract

Prader-Willi syndrome (PWS) is a contiguous gene syndrome characterized by uncontrollable eating or hyperphagia. Several studies have confirmed that plasma ghrelin levels are markedly elevated in PWS adults and children. The study of anorexigenic hormones is of interest because of their regulation of appetite by negative signals. To study the pattern and response of the anorexigenic hormones such as cholecystokinin (CCK) and peptide YY (PYY) to a meal in PWS, we measured the plasma CCK, PYY, ghrelin and serum insulin levels in PWS patients (n=4) and in controls (n=4) hourly for a day, and analyzed hormone levels and hormonal responses to meals. Repeated measures of ANOVA of hormone levels demonstrated that only insulin levels decreased (p=0.013) and CCK (p=0.005) and ghrelin (p=0.0007) increased in PWS over 24 hr. However, no significant group x time interactions (ghrelin: p=0.89, CCK: p=0.93, PYY: p=0.68 and insulin: p=0.85) were observed; in addition, there were no differences in an assessment of a three-hour area under the curve after breakfast. These results suggest that the response pattern of hormones to meals in PWS patients parallels that of normal controls. In addition, the decrease of insulin levels over 24 hr, in spite of obesity and elevated ghrelin levels, suggests that the baseline insulin level, not the insulin response to meals, may be abnormal in patients with PWS.

Authors+Show Affiliations

Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Irwon-dong, Gangnam-gu, Seoul, Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17596650

Citation

Paik, Kyung Hoon, et al. "Peptide YY, Cholecystokinin, Insulin and Ghrelin Response to Meal Did Not Change, but Mean Serum Levels of Insulin Is Reduced in Children With Prader-Willi Syndrome." Journal of Korean Medical Science, vol. 22, no. 3, 2007, pp. 436-41.
Paik KH, Jin DK, Lee KH, et al. Peptide YY, cholecystokinin, insulin and ghrelin response to meal did not change, but mean serum levels of insulin is reduced in children with Prader-Willi syndrome. J Korean Med Sci. 2007;22(3):436-41.
Paik, K. H., Jin, D. K., Lee, K. H., Armstrong, L., Lee, J. E., Oh, Y. J., ... Choe, Y. H. (2007). Peptide YY, cholecystokinin, insulin and ghrelin response to meal did not change, but mean serum levels of insulin is reduced in children with Prader-Willi syndrome. Journal of Korean Medical Science, 22(3), pp. 436-41.
Paik KH, et al. Peptide YY, Cholecystokinin, Insulin and Ghrelin Response to Meal Did Not Change, but Mean Serum Levels of Insulin Is Reduced in Children With Prader-Willi Syndrome. J Korean Med Sci. 2007;22(3):436-41. PubMed PMID: 17596650.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Peptide YY, cholecystokinin, insulin and ghrelin response to meal did not change, but mean serum levels of insulin is reduced in children with Prader-Willi syndrome. AU - Paik,Kyung Hoon, AU - Jin,Dong-Kyu, AU - Lee,Kyung Han, AU - Armstrong,Lee, AU - Lee,Ji Eun, AU - Oh,Yoo Joung, AU - Kim,Seonwoo, AU - Kwon,Eun Kyung, AU - Choe,Yon Ho, PY - 2007/6/29/pubmed PY - 2007/8/10/medline PY - 2007/6/29/entrez SP - 436 EP - 41 JF - Journal of Korean medical science JO - J. Korean Med. Sci. VL - 22 IS - 3 N2 - Prader-Willi syndrome (PWS) is a contiguous gene syndrome characterized by uncontrollable eating or hyperphagia. Several studies have confirmed that plasma ghrelin levels are markedly elevated in PWS adults and children. The study of anorexigenic hormones is of interest because of their regulation of appetite by negative signals. To study the pattern and response of the anorexigenic hormones such as cholecystokinin (CCK) and peptide YY (PYY) to a meal in PWS, we measured the plasma CCK, PYY, ghrelin and serum insulin levels in PWS patients (n=4) and in controls (n=4) hourly for a day, and analyzed hormone levels and hormonal responses to meals. Repeated measures of ANOVA of hormone levels demonstrated that only insulin levels decreased (p=0.013) and CCK (p=0.005) and ghrelin (p=0.0007) increased in PWS over 24 hr. However, no significant group x time interactions (ghrelin: p=0.89, CCK: p=0.93, PYY: p=0.68 and insulin: p=0.85) were observed; in addition, there were no differences in an assessment of a three-hour area under the curve after breakfast. These results suggest that the response pattern of hormones to meals in PWS patients parallels that of normal controls. In addition, the decrease of insulin levels over 24 hr, in spite of obesity and elevated ghrelin levels, suggests that the baseline insulin level, not the insulin response to meals, may be abnormal in patients with PWS. SN - 1011-8934 UR - https://www.unboundmedicine.com/medline/citation/17596650/Peptide_YY_cholecystokinin_insulin_and_ghrelin_response_to_meal_did_not_change_but_mean_serum_levels_of_insulin_is_reduced_in_children_with_Prader_Willi_syndrome_ L2 - https://jkms.org/DOIx.php?id=10.3346/jkms.2007.22.3.436 DB - PRIME DP - Unbound Medicine ER -