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Hepatitis B vaccination and first central nervous system demyelinating events: reanalysis of a case-control study using the self-controlled case series method.
Vaccine 2007; 25(31):5938-43V

Abstract

The hypothesis that hepatitis B vaccination is a risk factor for multiple sclerosis has been discussed at length. The data from an earlier case-control study were reanalyzed using the self-controlled case series method. Using the matched cases from the case-control study, we found a relative incidence of 1.68, 95% CI (0.77-3.68) for the 0-60-day post-vaccination risk period; this compares to an odds ratio of 1.8, 95% CI (0.7-4.6). When an additional 53 unmatched cases not used in the case-control study were included, the relative incidence was 1.35, 95% CI (0.66-2.79). Our results throw further light on the methodological aspects of the case series method. We recommend that, when case-control studies of vaccination and adverse events are planned, case series analyses based on the cases are also undertaken when appropriate.

Authors+Show Affiliations

INSERM U780, Université Paris XI, Villejuif, France. m.hocine@open.ac.ukNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17597263

Citation

Hocine, M N., et al. "Hepatitis B Vaccination and First Central Nervous System Demyelinating Events: Reanalysis of a Case-control Study Using the Self-controlled Case Series Method." Vaccine, vol. 25, no. 31, 2007, pp. 5938-43.
Hocine MN, Farrington CP, Touzé E, et al. Hepatitis B vaccination and first central nervous system demyelinating events: reanalysis of a case-control study using the self-controlled case series method. Vaccine. 2007;25(31):5938-43.
Hocine, M. N., Farrington, C. P., Touzé, E., Whitaker, H. J., Fourrier, A., Moreau, T., & Tubert-Bitter, P. (2007). Hepatitis B vaccination and first central nervous system demyelinating events: reanalysis of a case-control study using the self-controlled case series method. Vaccine, 25(31), pp. 5938-43.
Hocine MN, et al. Hepatitis B Vaccination and First Central Nervous System Demyelinating Events: Reanalysis of a Case-control Study Using the Self-controlled Case Series Method. Vaccine. 2007 Aug 1;25(31):5938-43. PubMed PMID: 17597263.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hepatitis B vaccination and first central nervous system demyelinating events: reanalysis of a case-control study using the self-controlled case series method. AU - Hocine,M N, AU - Farrington,C P, AU - Touzé,E, AU - Whitaker,H J, AU - Fourrier,A, AU - Moreau,T, AU - Tubert-Bitter,P, Y1 - 2007/06/08/ PY - 2007/04/19/received PY - 2007/05/10/revised PY - 2007/05/12/accepted PY - 2007/6/29/pubmed PY - 2007/10/20/medline PY - 2007/6/29/entrez SP - 5938 EP - 43 JF - Vaccine JO - Vaccine VL - 25 IS - 31 N2 - The hypothesis that hepatitis B vaccination is a risk factor for multiple sclerosis has been discussed at length. The data from an earlier case-control study were reanalyzed using the self-controlled case series method. Using the matched cases from the case-control study, we found a relative incidence of 1.68, 95% CI (0.77-3.68) for the 0-60-day post-vaccination risk period; this compares to an odds ratio of 1.8, 95% CI (0.7-4.6). When an additional 53 unmatched cases not used in the case-control study were included, the relative incidence was 1.35, 95% CI (0.66-2.79). Our results throw further light on the methodological aspects of the case series method. We recommend that, when case-control studies of vaccination and adverse events are planned, case series analyses based on the cases are also undertaken when appropriate. SN - 0264-410X UR - https://www.unboundmedicine.com/medline/citation/17597263/full_citation L2 - https://linkinghub.elsevier.com/retrieve/pii/S0264-410X(07)00594-4 DB - PRIME DP - Unbound Medicine ER -