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Preparation, characterization and in vivo evaluation of ibuprofen binary solid dispersions with poloxamer 188.
Int J Pharm. 2007 Oct 01; 343(1-2):228-37.IJ

Abstract

Ibuprofen-Poloxamer 188 (P 188) binary solid dispersions (SD) with different drug loadings were prepared, characterized by scanning electron microscopy (SEM), differential scanning calorimetry (DSC) and Fourier transform infrared spectroscopy (FTIR), and evaluated for solubility, in vitro release, and oral bioavailability of ibuprofen in rats. Loss of their individual surface properties during melting and solidification as revealed by SEM micrographs indicated the formation of effective SDs. Absence or shifting towards the lower melting temperature of the drug peak in SDs and physical mixtures in DSC study indicated the possibilities of its interactions with P 188. However, no such interactions in the solid state were confirmed by FTIR spectra which showed the presence of drug crystalline in SDs. Immediate and complete release of ibuprofen from SDs might be because of the reduction in the drug crystalline due to eutectic formation, and their dosing to fasted rats resulted in a significant increase in the area under curve (AUC) of the plasma concentration versus time curve and the maximum plasma concentration (Cmax), and a significant decrease in the time to reach Cmax (Tmax) over ibuprofen and physical mixtures.

Authors+Show Affiliations

College of Pharmacy, Yeungnam University, Gyongsan 712-749, South Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17597315

Citation

Newa, Madhuri, et al. "Preparation, Characterization and in Vivo Evaluation of Ibuprofen Binary Solid Dispersions With Poloxamer 188." International Journal of Pharmaceutics, vol. 343, no. 1-2, 2007, pp. 228-37.
Newa M, Bhandari KH, Li DX, et al. Preparation, characterization and in vivo evaluation of ibuprofen binary solid dispersions with poloxamer 188. Int J Pharm. 2007;343(1-2):228-37.
Newa, M., Bhandari, K. H., Li, D. X., Kwon, T. H., Kim, J. A., Yoo, B. K., Woo, J. S., Lyoo, W. S., Yong, C. S., & Choi, H. G. (2007). Preparation, characterization and in vivo evaluation of ibuprofen binary solid dispersions with poloxamer 188. International Journal of Pharmaceutics, 343(1-2), 228-37.
Newa M, et al. Preparation, Characterization and in Vivo Evaluation of Ibuprofen Binary Solid Dispersions With Poloxamer 188. Int J Pharm. 2007 Oct 1;343(1-2):228-37. PubMed PMID: 17597315.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Preparation, characterization and in vivo evaluation of ibuprofen binary solid dispersions with poloxamer 188. AU - Newa,Madhuri, AU - Bhandari,Krishna Hari, AU - Li,Dong Xun, AU - Kwon,Tae-Hyub, AU - Kim,Jung Ae, AU - Yoo,Bong Kyu, AU - Woo,Jong Soo, AU - Lyoo,Won Seok, AU - Yong,Chul Soon, AU - Choi,Han Gon, Y1 - 2007/05/21/ PY - 2007/01/24/received PY - 2007/04/05/revised PY - 2007/05/17/accepted PY - 2007/6/29/pubmed PY - 2007/12/6/medline PY - 2007/6/29/entrez SP - 228 EP - 37 JF - International journal of pharmaceutics JO - Int J Pharm VL - 343 IS - 1-2 N2 - Ibuprofen-Poloxamer 188 (P 188) binary solid dispersions (SD) with different drug loadings were prepared, characterized by scanning electron microscopy (SEM), differential scanning calorimetry (DSC) and Fourier transform infrared spectroscopy (FTIR), and evaluated for solubility, in vitro release, and oral bioavailability of ibuprofen in rats. Loss of their individual surface properties during melting and solidification as revealed by SEM micrographs indicated the formation of effective SDs. Absence or shifting towards the lower melting temperature of the drug peak in SDs and physical mixtures in DSC study indicated the possibilities of its interactions with P 188. However, no such interactions in the solid state were confirmed by FTIR spectra which showed the presence of drug crystalline in SDs. Immediate and complete release of ibuprofen from SDs might be because of the reduction in the drug crystalline due to eutectic formation, and their dosing to fasted rats resulted in a significant increase in the area under curve (AUC) of the plasma concentration versus time curve and the maximum plasma concentration (Cmax), and a significant decrease in the time to reach Cmax (Tmax) over ibuprofen and physical mixtures. SN - 0378-5173 UR - https://www.unboundmedicine.com/medline/citation/17597315/Preparation_characterization_and_in_vivo_evaluation_of_ibuprofen_binary_solid_dispersions_with_poloxamer_188_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-5173(07)00462-0 DB - PRIME DP - Unbound Medicine ER -