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Herpes simplex virus infection and genital ulcer disease among patients with sexually transmitted infections in Dar es Salaam, Tanzania.
Acta Derm Venereol. 2007; 87(4):355-9.AD

Abstract

The relative importance of Haemophilus ducreyi and Treponema pallidum in genital ulcer disease in Africa has decreased recently, whereas that of herpes simplex virus (HSV) type 2 has increased. We analysed 301 lesional specimens from Tanzanian patients with genital ulcer disease for the presence of H. ducreyi, T. pallidum and HSV-1/HSV-2 by performing a separate PCR for each pathogen. Infectious agents were detected in 211 (70%) of the cases. A single pathogen was found in 191 samples and two or more pathogens in the remaining 20. HSV-2 represented 83% of all identified pathogens, HSV-1 8%, T. pallidum 4% and H. ducreyi 5%. HSV-1 was identified as a single pathogen in four samples, in combination with others in an additional 14 samples. Thus, HSV-1 can also be the cause of genital ulcer disease in Africa. Regular surveillance of genital ulcer disease aetiology is important in programs for management of genital ulcer disease and HIV in Africa.

Authors+Show Affiliations

Department of Dermatology, Institute of Medicine, University of Bergen, Bergen, Norway. arvid.nilsen@helse-bergen.noNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17598041

Citation

Nilsen, Arvid, et al. "Herpes Simplex Virus Infection and Genital Ulcer Disease Among Patients With Sexually Transmitted Infections in Dar Es Salaam, Tanzania." Acta Dermato-venereologica, vol. 87, no. 4, 2007, pp. 355-9.
Nilsen A, Kasubi MJ, Mohn SC, et al. Herpes simplex virus infection and genital ulcer disease among patients with sexually transmitted infections in Dar es Salaam, Tanzania. Acta Derm Venereol. 2007;87(4):355-9.
Nilsen, A., Kasubi, M. J., Mohn, S. C., Mwakagile, D., Langeland, N., & Haarr, L. (2007). Herpes simplex virus infection and genital ulcer disease among patients with sexually transmitted infections in Dar es Salaam, Tanzania. Acta Dermato-venereologica, 87(4), 355-9.
Nilsen A, et al. Herpes Simplex Virus Infection and Genital Ulcer Disease Among Patients With Sexually Transmitted Infections in Dar Es Salaam, Tanzania. Acta Derm Venereol. 2007;87(4):355-9. PubMed PMID: 17598041.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Herpes simplex virus infection and genital ulcer disease among patients with sexually transmitted infections in Dar es Salaam, Tanzania. AU - Nilsen,Arvid, AU - Kasubi,Mabula Joseph, AU - Mohn,Stein Christian, AU - Mwakagile,Davis, AU - Langeland,Nina, AU - Haarr,Lars, PY - 2007/6/29/pubmed PY - 2007/10/19/medline PY - 2007/6/29/entrez SP - 355 EP - 9 JF - Acta dermato-venereologica JO - Acta Derm Venereol VL - 87 IS - 4 N2 - The relative importance of Haemophilus ducreyi and Treponema pallidum in genital ulcer disease in Africa has decreased recently, whereas that of herpes simplex virus (HSV) type 2 has increased. We analysed 301 lesional specimens from Tanzanian patients with genital ulcer disease for the presence of H. ducreyi, T. pallidum and HSV-1/HSV-2 by performing a separate PCR for each pathogen. Infectious agents were detected in 211 (70%) of the cases. A single pathogen was found in 191 samples and two or more pathogens in the remaining 20. HSV-2 represented 83% of all identified pathogens, HSV-1 8%, T. pallidum 4% and H. ducreyi 5%. HSV-1 was identified as a single pathogen in four samples, in combination with others in an additional 14 samples. Thus, HSV-1 can also be the cause of genital ulcer disease in Africa. Regular surveillance of genital ulcer disease aetiology is important in programs for management of genital ulcer disease and HIV in Africa. SN - 0001-5555 UR - https://www.unboundmedicine.com/medline/citation/17598041/Herpes_simplex_virus_infection_and_genital_ulcer_disease_among_patients_with_sexually_transmitted_infections_in_Dar_es_Salaam_Tanzania_ L2 - https://www.medicaljournals.se/acta/content/abstract/10.2340/00015555-0241 DB - PRIME DP - Unbound Medicine ER -