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Effect of the -420C/G variant of the resistin gene promoter on metabolic syndrome, obesity, myocardial infarction and kidney dysfunction.
J Intern Med. 2007 Jul; 262(1):104-12.JI

Abstract

OBJECTIVE

Resistin is an adipokine that has been suggested to be correlated with markers of inflammation and to be predictive of coronary atherosclerosis and type II diabetes in humans. A common single nucleotide polymorphism (SNP) (-420C/G) in the promoter of resistin is associated with increased resistin plasma levels and susceptibility to type II diabetes. The aim of this study was to investigate the association of the -420C/G polymorphism with metabolic syndrome, obesity, myocardial infarction and kidney disease.

DESIGN AND RESULTS

First we studied 1542 subjects from the PLIC study (a population based cohort). GG carriers showed an higher prevalence of obesity and metabolic syndrome as well as increased plasma triglycerides levels, BMI, systolic and diastolic blood pressure and cardiovascular risk according to Framingham algorithm (P < 0.05 for all). Next we investigated the presence of the -420C/G resistin polymorphism in a case-control study that included 300 subject with myocardial infarction and 300 age and sex matched controls and then we studied the role of the -420C/G SNP in 88 patients with mild to moderate renal dysfunction. No statistically significant differences in allele frequencies between the PLIC study, the myocardial infarction (MI) cases and the subjects with renal dysfunction were observed. Pro-inflammatory gene expression profiling of peripheral blood mononuclear cells failed to detect any difference between wild type subjects and carriers of the rare allele.

CONCLUSION

Our data suggest that the presence of the -420C/G SNP of the resistin gene is associated with increased obesity and metabolic syndrome, although it is not different in subjects at high cardiovascular risk such as patients with myocardial infarction or patients with renal dysfunction compared with controls.

Authors+Show Affiliations

Department of Pharmacological Sciences, University of Milan, Milan, Italy. Danilo.Norata@unimi.itNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17598818

Citation

Norata, G D., et al. "Effect of the -420C/G Variant of the Resistin Gene Promoter On Metabolic Syndrome, Obesity, Myocardial Infarction and Kidney Dysfunction." Journal of Internal Medicine, vol. 262, no. 1, 2007, pp. 104-12.
Norata GD, Ongari M, Garlaschelli K, et al. Effect of the -420C/G variant of the resistin gene promoter on metabolic syndrome, obesity, myocardial infarction and kidney dysfunction. J Intern Med. 2007;262(1):104-12.
Norata, G. D., Ongari, M., Garlaschelli, K., Tibolla, G., Grigore, L., Raselli, S., Vettoretti, S., Baragetti, I., Noto, D., Cefalù, A. B., Buccianti, G., Averna, M., & Catapano, A. L. (2007). Effect of the -420C/G variant of the resistin gene promoter on metabolic syndrome, obesity, myocardial infarction and kidney dysfunction. Journal of Internal Medicine, 262(1), 104-12.
Norata GD, et al. Effect of the -420C/G Variant of the Resistin Gene Promoter On Metabolic Syndrome, Obesity, Myocardial Infarction and Kidney Dysfunction. J Intern Med. 2007;262(1):104-12. PubMed PMID: 17598818.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of the -420C/G variant of the resistin gene promoter on metabolic syndrome, obesity, myocardial infarction and kidney dysfunction. AU - Norata,G D, AU - Ongari,M, AU - Garlaschelli,K, AU - Tibolla,G, AU - Grigore,L, AU - Raselli,S, AU - Vettoretti,S, AU - Baragetti,I, AU - Noto,D, AU - Cefalù,A B, AU - Buccianti,G, AU - Averna,M, AU - Catapano,A L, PY - 2007/6/30/pubmed PY - 2007/8/19/medline PY - 2007/6/30/entrez SP - 104 EP - 12 JF - Journal of internal medicine JO - J. Intern. Med. VL - 262 IS - 1 N2 - OBJECTIVE: Resistin is an adipokine that has been suggested to be correlated with markers of inflammation and to be predictive of coronary atherosclerosis and type II diabetes in humans. A common single nucleotide polymorphism (SNP) (-420C/G) in the promoter of resistin is associated with increased resistin plasma levels and susceptibility to type II diabetes. The aim of this study was to investigate the association of the -420C/G polymorphism with metabolic syndrome, obesity, myocardial infarction and kidney disease. DESIGN AND RESULTS: First we studied 1542 subjects from the PLIC study (a population based cohort). GG carriers showed an higher prevalence of obesity and metabolic syndrome as well as increased plasma triglycerides levels, BMI, systolic and diastolic blood pressure and cardiovascular risk according to Framingham algorithm (P < 0.05 for all). Next we investigated the presence of the -420C/G resistin polymorphism in a case-control study that included 300 subject with myocardial infarction and 300 age and sex matched controls and then we studied the role of the -420C/G SNP in 88 patients with mild to moderate renal dysfunction. No statistically significant differences in allele frequencies between the PLIC study, the myocardial infarction (MI) cases and the subjects with renal dysfunction were observed. Pro-inflammatory gene expression profiling of peripheral blood mononuclear cells failed to detect any difference between wild type subjects and carriers of the rare allele. CONCLUSION: Our data suggest that the presence of the -420C/G SNP of the resistin gene is associated with increased obesity and metabolic syndrome, although it is not different in subjects at high cardiovascular risk such as patients with myocardial infarction or patients with renal dysfunction compared with controls. SN - 0954-6820 UR - https://www.unboundmedicine.com/medline/citation/17598818/Effect_of_the__420C/G_variant_of_the_resistin_gene_promoter_on_metabolic_syndrome_obesity_myocardial_infarction_and_kidney_dysfunction_ L2 - https://doi.org/10.1111/j.1365-2796.2007.01787.x DB - PRIME DP - Unbound Medicine ER -