Tags

Type your tag names separated by a space and hit enter

Dysplasia and cancer in inflammatory bowel disease 10 years after diagnosis: results of a population-based European collaborative follow-up study.
Digestion. 2007; 75(2-3):113-21.D

Abstract

OBJECTIVE

To determine dysplasia and cancer in the 1991-2004 European Collaborative Inflammatory Bowel Disease (EC-IBD) Study Group cohort.

PATIENTS AND METHODS

A patient questionnaire and a physician per patient form were completed for each of the 1,141 inflammatory bowel disease patients (776 ulcerative colitis/365 Crohn's disease) from 9 centers (7 countries) derived from the EC-IBD cohort. Rates of detection of intestinal cancer and dysplasia as well as extra-intestinal neoplasms were computed.

RESULTS

Patient follow-up time was 10.3 +/- 0.8 (range 9.4-11) years. The mean age of the whole group of IBD patients was 37.8 +/- 11.3 (range 16-76) years. Thirty-eight patients (3.3%; 26 with ulcerative colitis/12 with Crohn's disease, 21 males/17 females, aged 61.3 +/- 13.4, range 33-77 years), were diagnosed with 42 cancers. Cancers occurred 5.4 +/- 3.3 (range 0-11) years after inflammatory bowel disease diagnosis. Colorectal cancer was diagnosed in 8 (1 Crohn's disease and 7 ulcerative colitis patients--0.3 and 0.9% of the Crohn's disease and ulcerative colitis cohort, respectively) of 38 patients and 30 cancers were extra-intestinal. Four of 38 patients (10.5%) were diagnosed as having 2 cancers and they were younger compared to patients with one cancer (p = 0.0008). There was a trend for a higher prevalence of intestinal cancer in the northern centers (0.9%) compared to southern centers (0.3%, p = NS). Southern centers had more cases of extra-intestinal cancer compared to northern centers (2 vs. 3.8%, p = 0.08). Ten patients (0.9%; 8 with ulcerative colitis/2 with Crohn's disease, 8 males, aged 62.3 +/- 14.1 years) had colorectal dysplasia.

CONCLUSIONS

In the first decade of the EC-IBD Study Group cohort follow-up study, the prevalence of cancer was as expected with most patients having a single neoplasm and an extra-intestinal neoplasm. In northern centers there was a trend for more intestinal cancers, while in southern centers there was a trend for more extra-intestinal cancers compared to northern centers.

Authors+Show Affiliations

Department of Gastroenterology, University Hospital of Ioannina, Ioannina, Greece.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17598963

Citation

Katsanos, K H., et al. "Dysplasia and Cancer in Inflammatory Bowel Disease 10 Years After Diagnosis: Results of a Population-based European Collaborative Follow-up Study." Digestion, vol. 75, no. 2-3, 2007, pp. 113-21.
Katsanos KH, Vermeire S, Christodoulou DK, et al. Dysplasia and cancer in inflammatory bowel disease 10 years after diagnosis: results of a population-based European collaborative follow-up study. Digestion. 2007;75(2-3):113-21.
Katsanos, K. H., Vermeire, S., Christodoulou, D. K., Riis, L., Wolters, F., Odes, S., Freitas, J., Hoie, O., Beltrami, M., Fornaciari, G., Clofent, J., Bodini, P., Vatn, M., Nunes, P. B., Moum, B., Munkholm, P., Limonard, C., Stockbrugger, R., Rutgeerts, P., & Tsianos, E. V. (2007). Dysplasia and cancer in inflammatory bowel disease 10 years after diagnosis: results of a population-based European collaborative follow-up study. Digestion, 75(2-3), 113-21.
Katsanos KH, et al. Dysplasia and Cancer in Inflammatory Bowel Disease 10 Years After Diagnosis: Results of a Population-based European Collaborative Follow-up Study. Digestion. 2007;75(2-3):113-21. PubMed PMID: 17598963.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dysplasia and cancer in inflammatory bowel disease 10 years after diagnosis: results of a population-based European collaborative follow-up study. AU - Katsanos,K H, AU - Vermeire,S, AU - Christodoulou,D K, AU - Riis,L, AU - Wolters,F, AU - Odes,S, AU - Freitas,J, AU - Hoie,Ole, AU - Beltrami,Marina, AU - Fornaciari,G, AU - Clofent,J, AU - Bodini,P, AU - Vatn,M, AU - Nunes,Paula Borralho, AU - Moum,B, AU - Munkholm,P, AU - Limonard,C, AU - Stockbrugger,R, AU - Rutgeerts,P, AU - Tsianos,E V, AU - ,, Y1 - 2007/06/26/ PY - 2007/02/21/received PY - 2007/04/26/accepted PY - 2007/6/30/pubmed PY - 2007/10/13/medline PY - 2007/6/30/entrez SP - 113 EP - 21 JF - Digestion JO - Digestion VL - 75 IS - 2-3 N2 - OBJECTIVE: To determine dysplasia and cancer in the 1991-2004 European Collaborative Inflammatory Bowel Disease (EC-IBD) Study Group cohort. PATIENTS AND METHODS: A patient questionnaire and a physician per patient form were completed for each of the 1,141 inflammatory bowel disease patients (776 ulcerative colitis/365 Crohn's disease) from 9 centers (7 countries) derived from the EC-IBD cohort. Rates of detection of intestinal cancer and dysplasia as well as extra-intestinal neoplasms were computed. RESULTS: Patient follow-up time was 10.3 +/- 0.8 (range 9.4-11) years. The mean age of the whole group of IBD patients was 37.8 +/- 11.3 (range 16-76) years. Thirty-eight patients (3.3%; 26 with ulcerative colitis/12 with Crohn's disease, 21 males/17 females, aged 61.3 +/- 13.4, range 33-77 years), were diagnosed with 42 cancers. Cancers occurred 5.4 +/- 3.3 (range 0-11) years after inflammatory bowel disease diagnosis. Colorectal cancer was diagnosed in 8 (1 Crohn's disease and 7 ulcerative colitis patients--0.3 and 0.9% of the Crohn's disease and ulcerative colitis cohort, respectively) of 38 patients and 30 cancers were extra-intestinal. Four of 38 patients (10.5%) were diagnosed as having 2 cancers and they were younger compared to patients with one cancer (p = 0.0008). There was a trend for a higher prevalence of intestinal cancer in the northern centers (0.9%) compared to southern centers (0.3%, p = NS). Southern centers had more cases of extra-intestinal cancer compared to northern centers (2 vs. 3.8%, p = 0.08). Ten patients (0.9%; 8 with ulcerative colitis/2 with Crohn's disease, 8 males, aged 62.3 +/- 14.1 years) had colorectal dysplasia. CONCLUSIONS: In the first decade of the EC-IBD Study Group cohort follow-up study, the prevalence of cancer was as expected with most patients having a single neoplasm and an extra-intestinal neoplasm. In northern centers there was a trend for more intestinal cancers, while in southern centers there was a trend for more extra-intestinal cancers compared to northern centers. SN - 1421-9867 UR - https://www.unboundmedicine.com/medline/citation/17598963/Dysplasia_and_cancer_in_inflammatory_bowel_disease_10_years_after_diagnosis:_results_of_a_population_based_European_collaborative_follow_up_study_ L2 - https://www.karger.com?DOI=10.1159/000104731 DB - PRIME DP - Unbound Medicine ER -