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Fasting glucose levels in predicting 1-year all-cause mortality in patients who do not have diabetes and are on maintenance hemodialysis.
J Am Soc Nephrol. 2007 Aug; 18(8):2385-91.JA

Abstract

Chronic inflammation and malnutrition relate to increased risks for cardiovascular death. This study compared fasting glucose levels (FGL) and impaired fasting glucose (IFG) with malnutrition and inflammation in nondiabetic maintenance hemodialysis (MHD) patients to investigate the adverse affects and risks for mortality. In total, 693 MHD patients were enrolled in this study and followed up for 1 yr. Geographic, hematologic, biochemical, and dialysis-related data were collected. According to 1997 and 2003 definitions, all patients were classified into three groups: Diabetic, nondiabetic with IFG, and nondiabetic with normal FGL. More diabetic and nondiabetic with IFG group patients were malnourished (chi(2) = 24.55, P < 0.0001) and had inflammatory changes (chi(2) = 9.32, P = 0.0095) than those with normal FGL. The IFG group had higher high-sensitivity C-reactive protein and ferritin and lower serum albumin, creatinine levels, and normalized protein catabolic rate than the normal FGL group. Age and parameters of nutrition and inflammation were associated with FGL. Stepwise multiple regression analysis demonstrated that FGL were negatively associated with serum albumin (P = 0.0026) and positively correlated with Log high-sensitivity C-reactive protein (P = 0.0004) in nondiabetic MHD patients. In addition, after 1 yr of follow-up, Cox multivariate analysis demonstrated that, after adjustment for other significant related factors, FGL (relative risk 1.049; 95% confidence interval 1.007 to 1.093; P = 0.0232) or presence of IFG (relative risk 3.798; 95% confidence interval 1.168 to 12.344; P = 0.0265) was a significant risk factor for 1-yr all-cause mortality of these patients. On the basis of these findings, basal FGL or presence of IFG, a preventive and treatable status, plays an important role in inflammation, malnutrition, and short-term mortality of nondiabetic MHD patients.

Authors+Show Affiliations

Lin-Kou Medical Center, Chang Gung Memorial Hospital, 199, Tung-Hwa North Road, Taipei, Taiwan, ROC.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17599971

Citation

Lin-Tan, Dan-Tzu, et al. "Fasting Glucose Levels in Predicting 1-year All-cause Mortality in Patients Who Do Not Have Diabetes and Are On Maintenance Hemodialysis." Journal of the American Society of Nephrology : JASN, vol. 18, no. 8, 2007, pp. 2385-91.
Lin-Tan DT, Lin JL, Wang LH, et al. Fasting glucose levels in predicting 1-year all-cause mortality in patients who do not have diabetes and are on maintenance hemodialysis. J Am Soc Nephrol. 2007;18(8):2385-91.
Lin-Tan, D. T., Lin, J. L., Wang, L. H., Wang, L. M., Huang, L. M., Liu, L., Huang, J. Y., & Huang, Y. L. (2007). Fasting glucose levels in predicting 1-year all-cause mortality in patients who do not have diabetes and are on maintenance hemodialysis. Journal of the American Society of Nephrology : JASN, 18(8), 2385-91.
Lin-Tan DT, et al. Fasting Glucose Levels in Predicting 1-year All-cause Mortality in Patients Who Do Not Have Diabetes and Are On Maintenance Hemodialysis. J Am Soc Nephrol. 2007;18(8):2385-91. PubMed PMID: 17599971.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Fasting glucose levels in predicting 1-year all-cause mortality in patients who do not have diabetes and are on maintenance hemodialysis. AU - Lin-Tan,Dan-Tzu, AU - Lin,Ja-Liang, AU - Wang,Li-Hua, AU - Wang,Li-Mei, AU - Huang,Lan-Mei, AU - Liu,Lily, AU - Huang,Jeng-Yi, AU - Huang,Yen-Lin, Y1 - 2007/06/28/ PY - 2007/6/30/pubmed PY - 2007/9/27/medline PY - 2007/6/30/entrez SP - 2385 EP - 91 JF - Journal of the American Society of Nephrology : JASN JO - J Am Soc Nephrol VL - 18 IS - 8 N2 - Chronic inflammation and malnutrition relate to increased risks for cardiovascular death. This study compared fasting glucose levels (FGL) and impaired fasting glucose (IFG) with malnutrition and inflammation in nondiabetic maintenance hemodialysis (MHD) patients to investigate the adverse affects and risks for mortality. In total, 693 MHD patients were enrolled in this study and followed up for 1 yr. Geographic, hematologic, biochemical, and dialysis-related data were collected. According to 1997 and 2003 definitions, all patients were classified into three groups: Diabetic, nondiabetic with IFG, and nondiabetic with normal FGL. More diabetic and nondiabetic with IFG group patients were malnourished (chi(2) = 24.55, P < 0.0001) and had inflammatory changes (chi(2) = 9.32, P = 0.0095) than those with normal FGL. The IFG group had higher high-sensitivity C-reactive protein and ferritin and lower serum albumin, creatinine levels, and normalized protein catabolic rate than the normal FGL group. Age and parameters of nutrition and inflammation were associated with FGL. Stepwise multiple regression analysis demonstrated that FGL were negatively associated with serum albumin (P = 0.0026) and positively correlated with Log high-sensitivity C-reactive protein (P = 0.0004) in nondiabetic MHD patients. In addition, after 1 yr of follow-up, Cox multivariate analysis demonstrated that, after adjustment for other significant related factors, FGL (relative risk 1.049; 95% confidence interval 1.007 to 1.093; P = 0.0232) or presence of IFG (relative risk 3.798; 95% confidence interval 1.168 to 12.344; P = 0.0265) was a significant risk factor for 1-yr all-cause mortality of these patients. On the basis of these findings, basal FGL or presence of IFG, a preventive and treatable status, plays an important role in inflammation, malnutrition, and short-term mortality of nondiabetic MHD patients. SN - 1046-6673 UR - https://www.unboundmedicine.com/medline/citation/17599971/Fasting_glucose_levels_in_predicting_1_year_all_cause_mortality_in_patients_who_do_not_have_diabetes_and_are_on_maintenance_hemodialysis_ L2 - https://jasn.asnjournals.org/cgi/pmidlookup?view=long&amp;pmid=17599971 DB - PRIME DP - Unbound Medicine ER -