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Narirutin inhibits airway inflammation in an allergic mouse model.
Clin Exp Pharmacol Physiol. 2007 Aug; 34(8):766-70.CE

Abstract

1. Flavonoids are naturally occurring compounds that possess anti-allergic, anti-inflammatory, antiproliferative and anti-oxidant properties. In the present study, we investigated whether the flavonoid narirutin could reduce airway inflammation in ovalbumin (OVA)-sensitized/challenged NC/Nga mice, a model of allergic eosinophilic airway inflammation. 2. Mice were initially immunized intraperitoneally with OVA on Days 0 and 7 and then challenged with inhaled OVA on Days 14, 15 and 16. In addition, some mice received narirutin orally at doses of 0.1, 1 or 10 mg/kg bodyweight daily on Days 7-16. 3. At 10 mg/kg, but not 0.1 or 1 mg/kg, narirutin significantly diminished OVA-induced airway inflammation caused by infiltration of lung tissue with inflammatory and mucus-producing cells, as well as reduced eosinophil counts in the peripheral blood and bronchoalveolar lavage fluid (BALF), interleukin (IL)-4 levels in BALF and IgE levels in serum. 4. The mechanism of the anti-inflammatory effect of narirutin are likely to be associated with a reduction in the OVA-induced increases of IL-4 and IgE in a murine model of allergic eosinophilic airway inflammation. These findings suggest that narirutin may be an effective new tool in the treatment of bronchial asthma.

Authors+Show Affiliations

Second Department of Internal Medicine, Regeneration and Advanced Medical Science, Graduate School of Medicine, Gifu University, Gifu, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17600554

Citation

Funaguchi, Norihiko, et al. "Narirutin Inhibits Airway Inflammation in an Allergic Mouse Model." Clinical and Experimental Pharmacology & Physiology, vol. 34, no. 8, 2007, pp. 766-70.
Funaguchi N, Ohno Y, La BL, et al. Narirutin inhibits airway inflammation in an allergic mouse model. Clin Exp Pharmacol Physiol. 2007;34(8):766-70.
Funaguchi, N., Ohno, Y., La, B. L., Asai, T., Yuhgetsu, H., Sawada, M., Takemura, G., Minatoguchi, S., Fujiwara, T., & Fujiwara, H. (2007). Narirutin inhibits airway inflammation in an allergic mouse model. Clinical and Experimental Pharmacology & Physiology, 34(8), 766-70.
Funaguchi N, et al. Narirutin Inhibits Airway Inflammation in an Allergic Mouse Model. Clin Exp Pharmacol Physiol. 2007;34(8):766-70. PubMed PMID: 17600554.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Narirutin inhibits airway inflammation in an allergic mouse model. AU - Funaguchi,Norihiko, AU - Ohno,Yasushi, AU - La,Bu Lin Bai, AU - Asai,Toshihiro, AU - Yuhgetsu,Hideyuki, AU - Sawada,Masahiro, AU - Takemura,Genzou, AU - Minatoguchi,Shinya, AU - Fujiwara,Takako, AU - Fujiwara,Hisayoshi, PY - 2007/6/30/pubmed PY - 2007/8/19/medline PY - 2007/6/30/entrez SP - 766 EP - 70 JF - Clinical and experimental pharmacology & physiology JO - Clin Exp Pharmacol Physiol VL - 34 IS - 8 N2 - 1. Flavonoids are naturally occurring compounds that possess anti-allergic, anti-inflammatory, antiproliferative and anti-oxidant properties. In the present study, we investigated whether the flavonoid narirutin could reduce airway inflammation in ovalbumin (OVA)-sensitized/challenged NC/Nga mice, a model of allergic eosinophilic airway inflammation. 2. Mice were initially immunized intraperitoneally with OVA on Days 0 and 7 and then challenged with inhaled OVA on Days 14, 15 and 16. In addition, some mice received narirutin orally at doses of 0.1, 1 or 10 mg/kg bodyweight daily on Days 7-16. 3. At 10 mg/kg, but not 0.1 or 1 mg/kg, narirutin significantly diminished OVA-induced airway inflammation caused by infiltration of lung tissue with inflammatory and mucus-producing cells, as well as reduced eosinophil counts in the peripheral blood and bronchoalveolar lavage fluid (BALF), interleukin (IL)-4 levels in BALF and IgE levels in serum. 4. The mechanism of the anti-inflammatory effect of narirutin are likely to be associated with a reduction in the OVA-induced increases of IL-4 and IgE in a murine model of allergic eosinophilic airway inflammation. These findings suggest that narirutin may be an effective new tool in the treatment of bronchial asthma. SN - 0305-1870 UR - https://www.unboundmedicine.com/medline/citation/17600554/Narirutin_inhibits_airway_inflammation_in_an_allergic_mouse_model_ L2 - https://doi.org/10.1111/j.1440-1681.2007.04636.x DB - PRIME DP - Unbound Medicine ER -