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Hidden in plain sight: Borrelia burgdorferi and the extracellular matrix.

Abstract

Borrelia burgdorferi, the tick-transmitted etiologic agent of Lyme borreliosis, can colonize and persist in multiple tissue sites despite vigorous host immune responses. The extracellular matrix appears to provide a protective niche for the spirochete. Recent studies in mice suggest that B. burgdorferi interacts in various ways with collagen and its associated molecules, exploiting molecular and structural features to establish microcolonial refugia. Better knowledge of the genetic and structural bases for these interactions of B. burgdorferi with the extracellular matrix will be required before an understanding of the persistence of B. burgdorferi in the tissues and development of chronic infections can be achieved.

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  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Department of Microbiology and Immunology, New York Medical College, Valhalla, NY 10595, USA. cabello@nymc.edu

    ,

    Source

    Trends in microbiology 15:8 2007 Aug pg 350-4

    MeSH

    Adhesins, Bacterial
    Animals
    Bacterial Adhesion
    Bacterial Outer Membrane Proteins
    Bacterial Proteins
    Borrelia burgdorferi
    Chronic Disease
    Collagen
    Decorin
    Extracellular Matrix
    Extracellular Matrix Proteins
    Gene Expression Regulation, Bacterial
    Humans
    Lyme Disease
    Mice
    Proteoglycans
    Virulence

    Pub Type(s)

    Journal Article
    Research Support, N.I.H., Extramural
    Research Support, U.S. Gov't, Non-P.H.S.

    Language

    eng

    PubMed ID

    17600717

    Citation

    TY - JOUR T1 - Hidden in plain sight: Borrelia burgdorferi and the extracellular matrix. AU - Cabello,Felipe C, AU - Godfrey,Henry P, AU - Newman,Stuart A, Y1 - 2007/06/27/ PY - 2007/2/19/received PY - 2007/6/13/accepted PY - 2007/6/27/aheadofprint PY - 2007/6/30/pubmed PY - 2007/10/18/medline PY - 2007/6/30/entrez SP - 350 EP - 4 JF - Trends in microbiology JO - Trends Microbiol. VL - 15 IS - 8 N2 - Borrelia burgdorferi, the tick-transmitted etiologic agent of Lyme borreliosis, can colonize and persist in multiple tissue sites despite vigorous host immune responses. The extracellular matrix appears to provide a protective niche for the spirochete. Recent studies in mice suggest that B. burgdorferi interacts in various ways with collagen and its associated molecules, exploiting molecular and structural features to establish microcolonial refugia. Better knowledge of the genetic and structural bases for these interactions of B. burgdorferi with the extracellular matrix will be required before an understanding of the persistence of B. burgdorferi in the tissues and development of chronic infections can be achieved. SN - 0966-842X UR - https://www.unboundmedicine.com/medline/citation/17600717/abstract/Hidden_in_plain_sight:_Borrelia_burgdorferi_and_the_ext L2 - http://linkinghub.elsevier.com/retrieve/pii/S0966-842X(07)00110-2 ER -