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Hidden in plain sight: Borrelia burgdorferi and the extracellular matrix.
Trends Microbiol 2007; 15(8):350-4TM

Abstract

Borrelia burgdorferi, the tick-transmitted etiologic agent of Lyme borreliosis, can colonize and persist in multiple tissue sites despite vigorous host immune responses. The extracellular matrix appears to provide a protective niche for the spirochete. Recent studies in mice suggest that B. burgdorferi interacts in various ways with collagen and its associated molecules, exploiting molecular and structural features to establish microcolonial refugia. Better knowledge of the genetic and structural bases for these interactions of B. burgdorferi with the extracellular matrix will be required before an understanding of the persistence of B. burgdorferi in the tissues and development of chronic infections can be achieved.

Authors+Show Affiliations

Department of Microbiology and Immunology, New York Medical College, Valhalla, NY 10595, USA. cabello@nymc.eduNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

17600717

Citation

Cabello, Felipe C., et al. "Hidden in Plain Sight: Borrelia Burgdorferi and the Extracellular Matrix." Trends in Microbiology, vol. 15, no. 8, 2007, pp. 350-4.
Cabello FC, Godfrey HP, Newman SA. Hidden in plain sight: Borrelia burgdorferi and the extracellular matrix. Trends Microbiol. 2007;15(8):350-4.
Cabello, F. C., Godfrey, H. P., & Newman, S. A. (2007). Hidden in plain sight: Borrelia burgdorferi and the extracellular matrix. Trends in Microbiology, 15(8), pp. 350-4.
Cabello FC, Godfrey HP, Newman SA. Hidden in Plain Sight: Borrelia Burgdorferi and the Extracellular Matrix. Trends Microbiol. 2007;15(8):350-4. PubMed PMID: 17600717.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hidden in plain sight: Borrelia burgdorferi and the extracellular matrix. AU - Cabello,Felipe C, AU - Godfrey,Henry P, AU - Newman,Stuart A, Y1 - 2007/06/27/ PY - 2007/02/19/received PY - 2007/06/13/accepted PY - 2007/6/30/pubmed PY - 2007/10/18/medline PY - 2007/6/30/entrez SP - 350 EP - 4 JF - Trends in microbiology JO - Trends Microbiol. VL - 15 IS - 8 N2 - Borrelia burgdorferi, the tick-transmitted etiologic agent of Lyme borreliosis, can colonize and persist in multiple tissue sites despite vigorous host immune responses. The extracellular matrix appears to provide a protective niche for the spirochete. Recent studies in mice suggest that B. burgdorferi interacts in various ways with collagen and its associated molecules, exploiting molecular and structural features to establish microcolonial refugia. Better knowledge of the genetic and structural bases for these interactions of B. burgdorferi with the extracellular matrix will be required before an understanding of the persistence of B. burgdorferi in the tissues and development of chronic infections can be achieved. SN - 0966-842X UR - https://www.unboundmedicine.com/medline/citation/17600717/abstract/Hidden_in_plain_sight:_Borrelia_burgdorferi_and_the_ext L2 - https://linkinghub.elsevier.com/retrieve/pii/S0966-842X(07)00110-2 DB - PRIME DP - Unbound Medicine ER -