Tags

Type your tag names separated by a space and hit enter

Impulse oscillometry for estimation of airway obstruction and bronchodilation in adults with mild obstructive asthma.
Ann Allergy Asthma Immunol 2007; 98(6):546-52AA

Abstract

BACKGROUND

Clinical validity of impulse oscillometry (IOS) for the evaluation of airway obstruction and bronchodilation is a controversial issue in adults with asthma.

METHODS

This study enrolled 195 outpatients from October 1998 to October 2004. We performed IOS in 158 asthmatic adults, including 70 asthmatic adults with a forced expiratory volume in 1 second (FEV,) reversibility (group 1), 88 asthmatic adults with hyperresponsiveness to methacholine or sputum eosinophilia (group 2) who did not meet the FEV, criteria, and 37 nonasthmatic adults (group 3).

RESULTS

Baseline respiratory resistance at 5 Hz (R5), respiratory resistance at 10 Hz, frequency dependency of resistance (R5 to 2)), and resonance frequency were discriminative between asthmatic patients and nonasthmatic patients. The IOS parameters were decreased after bronchodilation in both asthmatic groups compared with the nonasthmatic group. Among these patients, R5 and R5 to 21 were the most discriminative parameters for evaluation of bronchodilation. Approximately one third of the patients with positive methacholine challenge test results or sputum eosinophilia manifested bronchodilation evaluated by these IOS parameters. Overall sensitivities of these parameters were comparable to FEV, for diagnosis of bronchodilation in 158 asthmatic adults. Logistic regression analysis showed that R5 to 20 was the most reliable parameter for prediction of R5 reversibility for all asthmatic adults.

CONCLUSIONS

IOS may complement the estimation of obstruction and bronchodilation for asthmatic adults. Its discriminative power for airway obstruction and sensitivities for bronchodilation were comparable to FEV,.

Authors+Show Affiliations

Department of Internal Medicine, Institute of Allergy, Brain Korea 21. parkjw@yumc.yonsei.ac.krNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17601267

Citation

Park, Jung-Won, et al. "Impulse Oscillometry for Estimation of Airway Obstruction and Bronchodilation in Adults With Mild Obstructive Asthma." Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology, vol. 98, no. 6, 2007, pp. 546-52.
Park JW, Lee YW, Jung YH, et al. Impulse oscillometry for estimation of airway obstruction and bronchodilation in adults with mild obstructive asthma. Ann Allergy Asthma Immunol. 2007;98(6):546-52.
Park, J. W., Lee, Y. W., Jung, Y. H., Park, S. E., & Hong, C. S. (2007). Impulse oscillometry for estimation of airway obstruction and bronchodilation in adults with mild obstructive asthma. Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology, 98(6), pp. 546-52.
Park JW, et al. Impulse Oscillometry for Estimation of Airway Obstruction and Bronchodilation in Adults With Mild Obstructive Asthma. Ann Allergy Asthma Immunol. 2007;98(6):546-52. PubMed PMID: 17601267.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Impulse oscillometry for estimation of airway obstruction and bronchodilation in adults with mild obstructive asthma. AU - Park,Jung-Won, AU - Lee,Yong-Won, AU - Jung,Young-Hee, AU - Park,Se-Eun, AU - Hong,Chein-Soo, PY - 2007/7/3/pubmed PY - 2007/9/22/medline PY - 2007/7/3/entrez SP - 546 EP - 52 JF - Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology JO - Ann. Allergy Asthma Immunol. VL - 98 IS - 6 N2 - BACKGROUND: Clinical validity of impulse oscillometry (IOS) for the evaluation of airway obstruction and bronchodilation is a controversial issue in adults with asthma. METHODS: This study enrolled 195 outpatients from October 1998 to October 2004. We performed IOS in 158 asthmatic adults, including 70 asthmatic adults with a forced expiratory volume in 1 second (FEV,) reversibility (group 1), 88 asthmatic adults with hyperresponsiveness to methacholine or sputum eosinophilia (group 2) who did not meet the FEV, criteria, and 37 nonasthmatic adults (group 3). RESULTS: Baseline respiratory resistance at 5 Hz (R5), respiratory resistance at 10 Hz, frequency dependency of resistance (R5 to 2)), and resonance frequency were discriminative between asthmatic patients and nonasthmatic patients. The IOS parameters were decreased after bronchodilation in both asthmatic groups compared with the nonasthmatic group. Among these patients, R5 and R5 to 21 were the most discriminative parameters for evaluation of bronchodilation. Approximately one third of the patients with positive methacholine challenge test results or sputum eosinophilia manifested bronchodilation evaluated by these IOS parameters. Overall sensitivities of these parameters were comparable to FEV, for diagnosis of bronchodilation in 158 asthmatic adults. Logistic regression analysis showed that R5 to 20 was the most reliable parameter for prediction of R5 reversibility for all asthmatic adults. CONCLUSIONS: IOS may complement the estimation of obstruction and bronchodilation for asthmatic adults. Its discriminative power for airway obstruction and sensitivities for bronchodilation were comparable to FEV,. SN - 1081-1206 UR - https://www.unboundmedicine.com/medline/citation/17601267/Impulse_oscillometry_for_estimation_of_airway_obstruction_and_bronchodilation_in_adults_with_mild_obstructive_asthma_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1081-1206(10)60733-8 DB - PRIME DP - Unbound Medicine ER -