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Suppression of mast cell-mediated allergic reaction by Amomum xanthiodes.
Food Chem Toxicol. 2007 Nov; 45(11):2138-44.FC

Abstract

The mast cell-mediated immediate-type allergic reaction is involved in many allergic diseases such as asthma, allergic rhinitis and sinusitis. Stimulation of mast cells starts the process of degranulation resulting in release of mediators such as histamine and an array of inflammatory cytokines. In this report, we investigated the effect of aqueous extract of Amomum xanthiodes (Zingiberaceae) (AXE) on the mast cell-mediated allergy model and studied its possible mechanisms of action. AXE inhibited compound 48/80-induced systemic reactions and serum histamine release in mice. AXE decreased immunoglobulin E (IgE)-mediated passive cutaneous anaphylaxis reaction. AXE reduced histamine release and intracellular calcium from rat peritoneal mast cells activated by compound 48/80. Furthermore, AXE decreased the activation of p38 mitogen-activated protein kinase (MAPK) but not extracellular signal-regulated kinase and c-jun N-terminal kinase, and downstream tumor necrosis factor (TNF)-alpha production in phorbol 12-myristate 13-acetate and calcium ionophore A23187-stimulated human mast cells. Our findings provide evidence that AXE inhibits mast cell-derived allergic reactions, and that intracellular calcium, TNF-alpha, and p38 MAPK are involved in these effects.

Authors+Show Affiliations

Department of Pharmacology, Kyungpook National University Medical School, Daegu 700-422, Republic of Korea. shkim72@knu.ac.krNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17602813

Citation

Kim, Sang-Hyun, et al. "Suppression of Mast Cell-mediated Allergic Reaction By Amomum Xanthiodes." Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association, vol. 45, no. 11, 2007, pp. 2138-44.
Kim SH, Lee S, Kim IK, et al. Suppression of mast cell-mediated allergic reaction by Amomum xanthiodes. Food Chem Toxicol. 2007;45(11):2138-44.
Kim, S. H., Lee, S., Kim, I. K., Kwon, T. K., Moon, J. Y., Park, W. H., & Shin, T. Y. (2007). Suppression of mast cell-mediated allergic reaction by Amomum xanthiodes. Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association, 45(11), 2138-44.
Kim SH, et al. Suppression of Mast Cell-mediated Allergic Reaction By Amomum Xanthiodes. Food Chem Toxicol. 2007;45(11):2138-44. PubMed PMID: 17602813.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Suppression of mast cell-mediated allergic reaction by Amomum xanthiodes. AU - Kim,Sang-Hyun, AU - Lee,Soyoung, AU - Kim,In Kyeom, AU - Kwon,Taeg Kyu, AU - Moon,Jin-Young, AU - Park,Won-Hwan, AU - Shin,Tae-Yong, Y1 - 2007/05/24/ PY - 2006/09/22/received PY - 2007/04/23/revised PY - 2007/05/12/accepted PY - 2007/7/3/pubmed PY - 2007/12/7/medline PY - 2007/7/3/entrez SP - 2138 EP - 44 JF - Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association JO - Food Chem Toxicol VL - 45 IS - 11 N2 - The mast cell-mediated immediate-type allergic reaction is involved in many allergic diseases such as asthma, allergic rhinitis and sinusitis. Stimulation of mast cells starts the process of degranulation resulting in release of mediators such as histamine and an array of inflammatory cytokines. In this report, we investigated the effect of aqueous extract of Amomum xanthiodes (Zingiberaceae) (AXE) on the mast cell-mediated allergy model and studied its possible mechanisms of action. AXE inhibited compound 48/80-induced systemic reactions and serum histamine release in mice. AXE decreased immunoglobulin E (IgE)-mediated passive cutaneous anaphylaxis reaction. AXE reduced histamine release and intracellular calcium from rat peritoneal mast cells activated by compound 48/80. Furthermore, AXE decreased the activation of p38 mitogen-activated protein kinase (MAPK) but not extracellular signal-regulated kinase and c-jun N-terminal kinase, and downstream tumor necrosis factor (TNF)-alpha production in phorbol 12-myristate 13-acetate and calcium ionophore A23187-stimulated human mast cells. Our findings provide evidence that AXE inhibits mast cell-derived allergic reactions, and that intracellular calcium, TNF-alpha, and p38 MAPK are involved in these effects. SN - 0278-6915 UR - https://www.unboundmedicine.com/medline/citation/17602813/Suppression_of_mast_cell_mediated_allergic_reaction_by_Amomum_xanthiodes_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0278-6915(07)00173-1 DB - PRIME DP - Unbound Medicine ER -