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Stress and hypothalamic-pituitary-adrenal axis function in experimental autoimmune encephalomyelitis and multiple sclerosis - a review.
Psychoneuroendocrinology 2007; 32(6):604-18P

Abstract

Multiple sclerosis (MS) is an inflammatory and degenerative disease of the CNS with an assumed autoimmune-mediated pathogenesis. Stressful life events have been hypothesized as potential triggers of disease exacerbation. Animal studies using experimental autoimmune encephalomyelitis (EAE), as a model for MS, suggest that decreased hypothalamic-pituitary-adrenal (HPA) function may play a role in the increased susceptibility and severity of the disease. Histopathological studies of the hypothalamus point to disturbances in corticotropin-releasing hormone (CRH) regulation as a result of MS lesions in this area. Functional endocrine tests (e.g., the combined Dexamethasone-CRH test) showed a disturbed negative feedback after steroid application in MS patients. Hyper- and hypoactivity of the HPA axis, have been described to be associated with more severe courses. This paper presents an overview of the evidence for a role of HPA dysfunction in EAE and MS based on stress-experimental studies.

Authors+Show Affiliations

Institute of Neuroimmunology and Clinical MS Research (INiMS), University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany. heesen@uke.uni-hamburg.deNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

17602841

Citation

Heesen, C, et al. "Stress and Hypothalamic-pituitary-adrenal Axis Function in Experimental Autoimmune Encephalomyelitis and Multiple Sclerosis - a Review." Psychoneuroendocrinology, vol. 32, no. 6, 2007, pp. 604-18.
Heesen C, Gold SM, Huitinga I, et al. Stress and hypothalamic-pituitary-adrenal axis function in experimental autoimmune encephalomyelitis and multiple sclerosis - a review. Psychoneuroendocrinology. 2007;32(6):604-18.
Heesen, C., Gold, S. M., Huitinga, I., & Reul, J. M. (2007). Stress and hypothalamic-pituitary-adrenal axis function in experimental autoimmune encephalomyelitis and multiple sclerosis - a review. Psychoneuroendocrinology, 32(6), pp. 604-18.
Heesen C, et al. Stress and Hypothalamic-pituitary-adrenal Axis Function in Experimental Autoimmune Encephalomyelitis and Multiple Sclerosis - a Review. Psychoneuroendocrinology. 2007;32(6):604-18. PubMed PMID: 17602841.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Stress and hypothalamic-pituitary-adrenal axis function in experimental autoimmune encephalomyelitis and multiple sclerosis - a review. AU - Heesen,C, AU - Gold,S M, AU - Huitinga,I, AU - Reul,J M H M, Y1 - 2007/06/29/ PY - 2006/11/26/received PY - 2007/03/29/revised PY - 2007/05/04/accepted PY - 2007/7/3/pubmed PY - 2007/10/19/medline PY - 2007/7/3/entrez SP - 604 EP - 18 JF - Psychoneuroendocrinology JO - Psychoneuroendocrinology VL - 32 IS - 6 N2 - Multiple sclerosis (MS) is an inflammatory and degenerative disease of the CNS with an assumed autoimmune-mediated pathogenesis. Stressful life events have been hypothesized as potential triggers of disease exacerbation. Animal studies using experimental autoimmune encephalomyelitis (EAE), as a model for MS, suggest that decreased hypothalamic-pituitary-adrenal (HPA) function may play a role in the increased susceptibility and severity of the disease. Histopathological studies of the hypothalamus point to disturbances in corticotropin-releasing hormone (CRH) regulation as a result of MS lesions in this area. Functional endocrine tests (e.g., the combined Dexamethasone-CRH test) showed a disturbed negative feedback after steroid application in MS patients. Hyper- and hypoactivity of the HPA axis, have been described to be associated with more severe courses. This paper presents an overview of the evidence for a role of HPA dysfunction in EAE and MS based on stress-experimental studies. SN - 0306-4530 UR - https://www.unboundmedicine.com/medline/citation/17602841/Stress_and_hypothalamic_pituitary_adrenal_axis_function_in_experimental_autoimmune_encephalomyelitis_and_multiple_sclerosis___a_review_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0306-4530(07)00099-6 DB - PRIME DP - Unbound Medicine ER -