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Genetics of chronic pain states.

Abstract

Chronic pain states are common in the general population. Genetic factors can explain a significant amount of the variability in the perception of pain. Fibromyalgia syndrome (FMS) and related conditions are syndromes characterized by generalized pain sensitivity as well as a constellation of other symptoms. Family studies show a strong familial aggregation of FMS and related conditions, suggesting the importance of genetic factors in the development of these conditions. Recent evidence suggests a role for polymorphisms of genes in the serotoninergic, dopaminergic and catecholaminergic systems in the pathogenesis of FMS and related conditions. Environmental factors may trigger the development of these disorders in genetically predisposed individuals. Future large well-designed studies are needed to further clarify the role of genetic factors in FMS and related conditions. The knowledge of these gene polymorphisms may help with better subgrouping of FMS patients and in designing a more specific pharmacologic treatment approach.

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  • Publisher Full Text
  • Authors+Show Affiliations

    Department of Medicine H, Soroka Medical Center and Faculty of Health Sciences, Ben Gurion University, Beer Sheva, Israel 84101. dbuskila@bgumail.bgu.ac.il

    Source

    MeSH

    Chronic Disease
    Fibromyalgia
    Genetic Predisposition to Disease
    Humans
    Pain
    Polymorphism, Genetic

    Pub Type(s)

    Journal Article
    Review

    Language

    eng

    PubMed ID

    17602998

    Citation

    Buskila, Dan. "Genetics of Chronic Pain States." Best Practice & Research. Clinical Rheumatology, vol. 21, no. 3, 2007, pp. 535-47.
    Buskila D. Genetics of chronic pain states. Best Pract Res Clin Rheumatol. 2007;21(3):535-47.
    Buskila, D. (2007). Genetics of chronic pain states. Best Practice & Research. Clinical Rheumatology, 21(3), pp. 535-47.
    Buskila D. Genetics of Chronic Pain States. Best Pract Res Clin Rheumatol. 2007;21(3):535-47. PubMed PMID: 17602998.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Genetics of chronic pain states. A1 - Buskila,Dan, PY - 2007/7/3/pubmed PY - 2007/9/5/medline PY - 2007/7/3/entrez SP - 535 EP - 47 JF - Best practice & research. Clinical rheumatology JO - Best Pract Res Clin Rheumatol VL - 21 IS - 3 N2 - Chronic pain states are common in the general population. Genetic factors can explain a significant amount of the variability in the perception of pain. Fibromyalgia syndrome (FMS) and related conditions are syndromes characterized by generalized pain sensitivity as well as a constellation of other symptoms. Family studies show a strong familial aggregation of FMS and related conditions, suggesting the importance of genetic factors in the development of these conditions. Recent evidence suggests a role for polymorphisms of genes in the serotoninergic, dopaminergic and catecholaminergic systems in the pathogenesis of FMS and related conditions. Environmental factors may trigger the development of these disorders in genetically predisposed individuals. Future large well-designed studies are needed to further clarify the role of genetic factors in FMS and related conditions. The knowledge of these gene polymorphisms may help with better subgrouping of FMS patients and in designing a more specific pharmacologic treatment approach. SN - 1521-6942 UR - https://www.unboundmedicine.com/medline/citation/17602998/Genetics_of_chronic_pain_states_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1521-6942(07)00029-0 DB - PRIME DP - Unbound Medicine ER -