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Genetics of chronic pain states.
Best Pract Res Clin Rheumatol 2007; 21(3):535-47BP

Abstract

Chronic pain states are common in the general population. Genetic factors can explain a significant amount of the variability in the perception of pain. Fibromyalgia syndrome (FMS) and related conditions are syndromes characterized by generalized pain sensitivity as well as a constellation of other symptoms. Family studies show a strong familial aggregation of FMS and related conditions, suggesting the importance of genetic factors in the development of these conditions. Recent evidence suggests a role for polymorphisms of genes in the serotoninergic, dopaminergic and catecholaminergic systems in the pathogenesis of FMS and related conditions. Environmental factors may trigger the development of these disorders in genetically predisposed individuals. Future large well-designed studies are needed to further clarify the role of genetic factors in FMS and related conditions. The knowledge of these gene polymorphisms may help with better subgrouping of FMS patients and in designing a more specific pharmacologic treatment approach.

Authors+Show Affiliations

Department of Medicine H, Soroka Medical Center and Faculty of Health Sciences, Ben Gurion University, Beer Sheva, Israel 84101. dbuskila@bgumail.bgu.ac.il

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

17602998

Citation

Buskila, Dan. "Genetics of Chronic Pain States." Best Practice & Research. Clinical Rheumatology, vol. 21, no. 3, 2007, pp. 535-47.
Buskila D. Genetics of chronic pain states. Best Pract Res Clin Rheumatol. 2007;21(3):535-47.
Buskila, D. (2007). Genetics of chronic pain states. Best Practice & Research. Clinical Rheumatology, 21(3), pp. 535-47.
Buskila D. Genetics of Chronic Pain States. Best Pract Res Clin Rheumatol. 2007;21(3):535-47. PubMed PMID: 17602998.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Genetics of chronic pain states. A1 - Buskila,Dan, PY - 2007/7/3/pubmed PY - 2007/9/5/medline PY - 2007/7/3/entrez SP - 535 EP - 47 JF - Best practice & research. Clinical rheumatology JO - Best Pract Res Clin Rheumatol VL - 21 IS - 3 N2 - Chronic pain states are common in the general population. Genetic factors can explain a significant amount of the variability in the perception of pain. Fibromyalgia syndrome (FMS) and related conditions are syndromes characterized by generalized pain sensitivity as well as a constellation of other symptoms. Family studies show a strong familial aggregation of FMS and related conditions, suggesting the importance of genetic factors in the development of these conditions. Recent evidence suggests a role for polymorphisms of genes in the serotoninergic, dopaminergic and catecholaminergic systems in the pathogenesis of FMS and related conditions. Environmental factors may trigger the development of these disorders in genetically predisposed individuals. Future large well-designed studies are needed to further clarify the role of genetic factors in FMS and related conditions. The knowledge of these gene polymorphisms may help with better subgrouping of FMS patients and in designing a more specific pharmacologic treatment approach. SN - 1521-6942 UR - https://www.unboundmedicine.com/medline/citation/17602998/Genetics_of_chronic_pain_states_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1521-6942(07)00029-0 DB - PRIME DP - Unbound Medicine ER -