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Statistically significant changes of antimüllerian hormone and inhibin levels during the physiologic menstrual cycle in reproductive age women.
Fertil Steril. 2008 Apr; 89(4):927-33.FS

Abstract

OBJECTIVE

To define the dynamics of antimüllerian hormone (AMH) and inhibins during the physiologic menstrual cycle.

DESIGN

Longitudinal study.

SETTING

University hospital.

PATIENT(S)

36 young, healthy, normal weight Caucasian women without medication.

INTERVENTION(S)

Normal ovulatory menstrual cycles were evaluated by regular blood sampling taken every other day and periovulatory every day.

MAIN OUTCOME MEASURE(S)

Serum concentrations of AMH, inhibin A and B, follicle-stimulating hormone (FSH), luteinizing hormone (LH), prolactin, estradiol, progesterone, and free testosterone were measured in all blood samples.

RESULT(S)

Median AMH levels are statistically significantly higher in the late follicular compared with ovulation or the early luteal phase. There are statistically significant correlations between both AMH and FSH, and AMH and free testosterone in all cycle phases. Inhibin A increases strongly in the late follicular phase and peaks at day LH + 4. Inhibin B shows a broad midfollicular and a sharp early luteal peak, the difference being statistically significant between day LH + 4 and the earlier time points and between day LH + 2 and day LH. Although there is a negative association between inhibin A or B and the body mass index (BMI), there is no correlation between AMH and the BMI.

CONCLUSION(S)

Levels of AMH show a statistically significant change during the menstrual cycle and may influence the circulating gonadotropin and steroid hormone levels.

Authors+Show Affiliations

Department of Obstetrics and Gynaecology, University of Berne, Berne, Switzerland. dorothea.wunder@insel.chNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17603052

Citation

Wunder, Dorothea M., et al. "Statistically Significant Changes of Antimüllerian Hormone and Inhibin Levels During the Physiologic Menstrual Cycle in Reproductive Age Women." Fertility and Sterility, vol. 89, no. 4, 2008, pp. 927-33.
Wunder DM, Bersinger NA, Yared M, et al. Statistically significant changes of antimüllerian hormone and inhibin levels during the physiologic menstrual cycle in reproductive age women. Fertil Steril. 2008;89(4):927-33.
Wunder, D. M., Bersinger, N. A., Yared, M., Kretschmer, R., & Birkhäuser, M. H. (2008). Statistically significant changes of antimüllerian hormone and inhibin levels during the physiologic menstrual cycle in reproductive age women. Fertility and Sterility, 89(4), 927-33.
Wunder DM, et al. Statistically Significant Changes of Antimüllerian Hormone and Inhibin Levels During the Physiologic Menstrual Cycle in Reproductive Age Women. Fertil Steril. 2008;89(4):927-33. PubMed PMID: 17603052.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Statistically significant changes of antimüllerian hormone and inhibin levels during the physiologic menstrual cycle in reproductive age women. AU - Wunder,Dorothea M, AU - Bersinger,Nick A, AU - Yared,Mengistu, AU - Kretschmer,Robert, AU - Birkhäuser,Martin H, Y1 - 2007/07/02/ PY - 2007/01/24/received PY - 2007/04/24/revised PY - 2007/04/24/accepted PY - 2007/7/3/pubmed PY - 2008/4/30/medline PY - 2007/7/3/entrez SP - 927 EP - 33 JF - Fertility and sterility JO - Fertil Steril VL - 89 IS - 4 N2 - OBJECTIVE: To define the dynamics of antimüllerian hormone (AMH) and inhibins during the physiologic menstrual cycle. DESIGN: Longitudinal study. SETTING: University hospital. PATIENT(S): 36 young, healthy, normal weight Caucasian women without medication. INTERVENTION(S): Normal ovulatory menstrual cycles were evaluated by regular blood sampling taken every other day and periovulatory every day. MAIN OUTCOME MEASURE(S): Serum concentrations of AMH, inhibin A and B, follicle-stimulating hormone (FSH), luteinizing hormone (LH), prolactin, estradiol, progesterone, and free testosterone were measured in all blood samples. RESULT(S): Median AMH levels are statistically significantly higher in the late follicular compared with ovulation or the early luteal phase. There are statistically significant correlations between both AMH and FSH, and AMH and free testosterone in all cycle phases. Inhibin A increases strongly in the late follicular phase and peaks at day LH + 4. Inhibin B shows a broad midfollicular and a sharp early luteal peak, the difference being statistically significant between day LH + 4 and the earlier time points and between day LH + 2 and day LH. Although there is a negative association between inhibin A or B and the body mass index (BMI), there is no correlation between AMH and the BMI. CONCLUSION(S): Levels of AMH show a statistically significant change during the menstrual cycle and may influence the circulating gonadotropin and steroid hormone levels. SN - 1556-5653 UR - https://www.unboundmedicine.com/medline/citation/17603052/Statistically_significant_changes_of_antimüllerian_hormone_and_inhibin_levels_during_the_physiologic_menstrual_cycle_in_reproductive_age_women_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0015-0282(07)01017-5 DB - PRIME DP - Unbound Medicine ER -