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Soy isoflavones and fatty acids: effects on bone tissue postovariectomy in mice.
Mol Nutr Food Res. 2007 Jul; 51(7):824-31.MN

Abstract

Osteoporosis is a silent disease that leads to fragility fractures that can diminish quality of life and contribute to death. With no ideal drug treatment available to manage osteoporosis, soy isoflavones (ISO), and omega-3 long chain PUFAs in fish oil (FO) may be integral in a dietary strategy that prevents bone loss. The overall objective of this study was to determine if combining ISO with omega-3 long chain PUFAs resulted in greater protection against the loss of bone mineral and skeletal weakening in ovariectomized mice. Ovariectomized CD-1 mice were randomized to control diet or a diet containing ISO alone (250 mg of genistein + 250 mg of daidzein/kg diet), FO alone (7% menhaden oil), or ISO + FO. Each dietary intervention prevented the loss of bone mineral density (BMD) in the femur and preserved femur strength, but only FO, either alone or combined with ISO, resulted in a higher BMD of lumbar vertebra (LV). Most notably, FO + ISO resulted in a higher peak load of LV4, indicating that vertebra were more resistant to fracture. Whether a dietary strategy providing FO in combination with ISO attenuates bone loss in postmenopausal women awaits investigation.

Authors+Show Affiliations

Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada. wendy.ward@utoronto.caNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17604386

Citation

Ward, Wendy E., and Debbie Fonseca. "Soy Isoflavones and Fatty Acids: Effects On Bone Tissue Postovariectomy in Mice." Molecular Nutrition & Food Research, vol. 51, no. 7, 2007, pp. 824-31.
Ward WE, Fonseca D. Soy isoflavones and fatty acids: effects on bone tissue postovariectomy in mice. Mol Nutr Food Res. 2007;51(7):824-31.
Ward, W. E., & Fonseca, D. (2007). Soy isoflavones and fatty acids: effects on bone tissue postovariectomy in mice. Molecular Nutrition & Food Research, 51(7), 824-31.
Ward WE, Fonseca D. Soy Isoflavones and Fatty Acids: Effects On Bone Tissue Postovariectomy in Mice. Mol Nutr Food Res. 2007;51(7):824-31. PubMed PMID: 17604386.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Soy isoflavones and fatty acids: effects on bone tissue postovariectomy in mice. AU - Ward,Wendy E, AU - Fonseca,Debbie, PY - 2007/7/3/pubmed PY - 2007/11/10/medline PY - 2007/7/3/entrez SP - 824 EP - 31 JF - Molecular nutrition & food research JO - Mol Nutr Food Res VL - 51 IS - 7 N2 - Osteoporosis is a silent disease that leads to fragility fractures that can diminish quality of life and contribute to death. With no ideal drug treatment available to manage osteoporosis, soy isoflavones (ISO), and omega-3 long chain PUFAs in fish oil (FO) may be integral in a dietary strategy that prevents bone loss. The overall objective of this study was to determine if combining ISO with omega-3 long chain PUFAs resulted in greater protection against the loss of bone mineral and skeletal weakening in ovariectomized mice. Ovariectomized CD-1 mice were randomized to control diet or a diet containing ISO alone (250 mg of genistein + 250 mg of daidzein/kg diet), FO alone (7% menhaden oil), or ISO + FO. Each dietary intervention prevented the loss of bone mineral density (BMD) in the femur and preserved femur strength, but only FO, either alone or combined with ISO, resulted in a higher BMD of lumbar vertebra (LV). Most notably, FO + ISO resulted in a higher peak load of LV4, indicating that vertebra were more resistant to fracture. Whether a dietary strategy providing FO in combination with ISO attenuates bone loss in postmenopausal women awaits investigation. SN - 1613-4125 UR - https://www.unboundmedicine.com/medline/citation/17604386/Soy_isoflavones_and_fatty_acids:_effects_on_bone_tissue_postovariectomy_in_mice_ L2 - https://doi.org/10.1002/mnfr.200600187 DB - PRIME DP - Unbound Medicine ER -