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Epidemic meningitis, meningococcaemia, and Neisseria meningitidis.
Lancet. 2007 Jun 30; 369(9580):2196-2210.Lct

Abstract

Meningococcus, an obligate human bacterial pathogen, remains a worldwide and devastating cause of epidemic meningitis and sepsis. However, advances have been made in our understanding of meningococcal biology and pathogenesis, global epidemiology, transmission and carriage, host susceptibility, pathophysiology, and clinical presentations. Approaches to diagnosis, treatment, and chemoprophylaxis are now in use on the basis of these advances. Importantly, the next generation of meningococcal conjugate vaccines for serogroups A, C, Y, W-135, and broadly effective serogroup B vaccines are on the horizon, which could eliminate the organism as a major threat to human health in industrialised countries in the next decade. The crucial challenge will be effective introduction of new meningococcal vaccines into developing countries, especially in sub-Saharan Africa, where they are urgently needed.

Authors+Show Affiliations

Emory University School of Medicine, Atlanta, GA, USA; Research Service (151I), Atlanta VA Medical Center, Decatur, GA, USA. Electronic address: dstep01@emory.edu.London School of Hygiene and Tropical Medicine, London, UK.Departments of Paediatrics and Clinical Chemistry, Ullevål University Hospital and Faculty of Medicine, University of Oslo, Oslo, Norway.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

17604802

Citation

Stephens, David S., et al. "Epidemic Meningitis, Meningococcaemia, and Neisseria Meningitidis." Lancet (London, England), vol. 369, no. 9580, 2007, pp. 2196-2210.
Stephens DS, Greenwood B, Brandtzaeg P. Epidemic meningitis, meningococcaemia, and Neisseria meningitidis. Lancet. 2007;369(9580):2196-2210.
Stephens, D. S., Greenwood, B., & Brandtzaeg, P. (2007). Epidemic meningitis, meningococcaemia, and Neisseria meningitidis. Lancet (London, England), 369(9580), 2196-2210. https://doi.org/10.1016/S0140-6736(07)61016-2
Stephens DS, Greenwood B, Brandtzaeg P. Epidemic Meningitis, Meningococcaemia, and Neisseria Meningitidis. Lancet. 2007 Jun 30;369(9580):2196-2210. PubMed PMID: 17604802.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Epidemic meningitis, meningococcaemia, and Neisseria meningitidis. AU - Stephens,David S, AU - Greenwood,Brian, AU - Brandtzaeg,Petter, PY - 2007/7/3/pubmed PY - 2007/7/13/medline PY - 2007/7/3/entrez SP - 2196 EP - 2210 JF - Lancet (London, England) JO - Lancet VL - 369 IS - 9580 N2 - Meningococcus, an obligate human bacterial pathogen, remains a worldwide and devastating cause of epidemic meningitis and sepsis. However, advances have been made in our understanding of meningococcal biology and pathogenesis, global epidemiology, transmission and carriage, host susceptibility, pathophysiology, and clinical presentations. Approaches to diagnosis, treatment, and chemoprophylaxis are now in use on the basis of these advances. Importantly, the next generation of meningococcal conjugate vaccines for serogroups A, C, Y, W-135, and broadly effective serogroup B vaccines are on the horizon, which could eliminate the organism as a major threat to human health in industrialised countries in the next decade. The crucial challenge will be effective introduction of new meningococcal vaccines into developing countries, especially in sub-Saharan Africa, where they are urgently needed. SN - 1474-547X UR - https://www.unboundmedicine.com/medline/citation/17604802/full_citation L2 - https://linkinghub.elsevier.com/retrieve/pii/S0140-6736(07)61016-2 DB - PRIME DP - Unbound Medicine ER -