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Dystrophic neurites infiltrate extracellular neurofibrillary tangles in Alzheimer disease.
Brain Res. 1991 Sep 27; 560(1-2):303-5.BR

Abstract

The neurotrophic activity of beta-amyloid protein (beta-AP) has been suggested to be responsible for the dystrophic neurites that surround beta-AP deposits in senile plaques of Alzheimer disease. The recent finding that neurofibrillary tangles (NFT) that remain as remnants in the extracellular space (E-NFT) after the death of the neuron contain beta-AP, suggested that dystrophic neurites might also be associated with E-NFT. In this study, we use a probe for E-NFT, basic fibroblast growth factor (bFGF)-binding to show that E-NFT do contain dystrophic neurites. Since these neurites contain the amyloid precursor protein whose cleavage can lead to beta-AP, they may also play a role in further beta-AP deposition in the E-NFT.

Authors+Show Affiliations

Vande Weghe J
Division of Neuropathology, Institute of Pathology, Case Western Reserve University, Cleveland, OH 44106.
Cras P
No affiliation info available
Kawai M
No affiliation info available
Siedlak SL
No affiliation info available
Tabaton M
No affiliation info available
Greenberg B
No affiliation info available
Perry G
No affiliation info available

MeSH

AgedAlzheimer DiseaseAmyloid beta-PeptidesExtracellular SpaceHumansNeuritesNeurofibrillary Tanglestau Proteins

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

1760735

Citation

Vande Weghe, J, et al. "Dystrophic Neurites Infiltrate Extracellular Neurofibrillary Tangles in Alzheimer Disease." Brain Research, vol. 560, no. 1-2, 1991, pp. 303-5.
Vande Weghe J, Cras P, Kawai M, et al. Dystrophic neurites infiltrate extracellular neurofibrillary tangles in Alzheimer disease. Brain Res. 1991;560(1-2):303-5.
Vande Weghe, J., Cras, P., Kawai, M., Siedlak, S. L., Tabaton, M., Greenberg, B., & Perry, G. (1991). Dystrophic neurites infiltrate extracellular neurofibrillary tangles in Alzheimer disease. Brain Research, 560(1-2), 303-5.
Vande Weghe J, et al. Dystrophic Neurites Infiltrate Extracellular Neurofibrillary Tangles in Alzheimer Disease. Brain Res. 1991 Sep 27;560(1-2):303-5. PubMed PMID: 1760735.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dystrophic neurites infiltrate extracellular neurofibrillary tangles in Alzheimer disease. AU - Vande Weghe,J, AU - Cras,P, AU - Kawai,M, AU - Siedlak,S L, AU - Tabaton,M, AU - Greenberg,B, AU - Perry,G, PY - 1991/9/27/pubmed PY - 1991/9/27/medline PY - 1991/9/27/entrez SP - 303 EP - 5 JF - Brain research JO - Brain Res VL - 560 IS - 1-2 N2 - The neurotrophic activity of beta-amyloid protein (beta-AP) has been suggested to be responsible for the dystrophic neurites that surround beta-AP deposits in senile plaques of Alzheimer disease. The recent finding that neurofibrillary tangles (NFT) that remain as remnants in the extracellular space (E-NFT) after the death of the neuron contain beta-AP, suggested that dystrophic neurites might also be associated with E-NFT. In this study, we use a probe for E-NFT, basic fibroblast growth factor (bFGF)-binding to show that E-NFT do contain dystrophic neurites. Since these neurites contain the amyloid precursor protein whose cleavage can lead to beta-AP, they may also play a role in further beta-AP deposition in the E-NFT. SN - 0006-8993 UR - https://www.unboundmedicine.com/medline/citation/1760735/Dystrophic_neurites_infiltrate_extracellular_neurofibrillary_tangles_in_Alzheimer_disease_ DB - PRIME DP - Unbound Medicine ER -