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[Validation of a short test (3MS-R) for detecting Alzheimer's disease].
Fortschr Neurol Psychiatr. 2007 Dec; 75(12):728-36.FN

Abstract

BACKGROUND

The Modified Mini-Mental State Examination-revised (3MS-R) is a brief cognitive test designed to detect cognitive impairment, which is often used in Canada and USA.

OBJECTIVE

To assess the accuracy of the 3MS-R in identifying Alzheimer's disease (AD) in comparison with the conventional Mini-Mental State Examination (MMSE) in a German-speaking population.

SUBJECTS

The study refers to 31 patients with early AD and 5 patients with moderate dementia of AD etiology, as well as to 46 age-matched cognitively normal participants.

METHOD

The 3MS-R and the MMSE were validated against an expert diagnosis based on a comprehensive diagnostic workup. The 3MS scores were adjusted for educational attainment. Statistical analysis was performed using the Receiver Operating Characteristics (ROC).

RESULTS

ROC curves demonstrated the superiority of the ACE over the MMSE in identifying AD (Area under the Curve: 3MS-R vs. MMSE: 0.995 vs.0.953). The optimal cut-off score for the 3MS for detecting AD was 88 and had a sensitivity of 98% and a specificity of 94%. The German version of the 3MS-R is a short and practical but accurate test battery for the identification of AD. The effectiveness of the German version of the test in detecting other forms of dementias or mild cognitive impairment could be a task for future studies.

Authors+Show Affiliations

Psychiatrie und Psychotherapie Klinik, Friedrich-Alexander Universität Erlangen-Nürnberg, Erlangen. panagiotis.alexopoulos@uk-erlangen.deNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Validation Study

Language

ger

PubMed ID

17607642

Citation

Alexopoulos, P, et al. "[Validation of a Short Test (3MS-R) for Detecting Alzheimer's Disease]." Fortschritte Der Neurologie-Psychiatrie, vol. 75, no. 12, 2007, pp. 728-36.
Alexopoulos P, Nadler K, Cramer B, et al. [Validation of a short test (3MS-R) for detecting Alzheimer's disease]. Fortschr Neurol Psychiatr. 2007;75(12):728-36.
Alexopoulos, P., Nadler, K., Cramer, B., Herpertz, S. C., & Kurz, A. (2007). [Validation of a short test (3MS-R) for detecting Alzheimer's disease]. Fortschritte Der Neurologie-Psychiatrie, 75(12), 728-36.
Alexopoulos P, et al. [Validation of a Short Test (3MS-R) for Detecting Alzheimer's Disease]. Fortschr Neurol Psychiatr. 2007;75(12):728-36. PubMed PMID: 17607642.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Validation of a short test (3MS-R) for detecting Alzheimer's disease]. AU - Alexopoulos,P, AU - Nadler,K, AU - Cramer,B, AU - Herpertz,S C, AU - Kurz,A, Y1 - 2007/07/03/ PY - 2007/7/4/pubmed PY - 2008/2/26/medline PY - 2007/7/4/entrez SP - 728 EP - 36 JF - Fortschritte der Neurologie-Psychiatrie JO - Fortschr Neurol Psychiatr VL - 75 IS - 12 N2 - BACKGROUND: The Modified Mini-Mental State Examination-revised (3MS-R) is a brief cognitive test designed to detect cognitive impairment, which is often used in Canada and USA. OBJECTIVE: To assess the accuracy of the 3MS-R in identifying Alzheimer's disease (AD) in comparison with the conventional Mini-Mental State Examination (MMSE) in a German-speaking population. SUBJECTS: The study refers to 31 patients with early AD and 5 patients with moderate dementia of AD etiology, as well as to 46 age-matched cognitively normal participants. METHOD: The 3MS-R and the MMSE were validated against an expert diagnosis based on a comprehensive diagnostic workup. The 3MS scores were adjusted for educational attainment. Statistical analysis was performed using the Receiver Operating Characteristics (ROC). RESULTS: ROC curves demonstrated the superiority of the ACE over the MMSE in identifying AD (Area under the Curve: 3MS-R vs. MMSE: 0.995 vs.0.953). The optimal cut-off score for the 3MS for detecting AD was 88 and had a sensitivity of 98% and a specificity of 94%. The German version of the 3MS-R is a short and practical but accurate test battery for the identification of AD. The effectiveness of the German version of the test in detecting other forms of dementias or mild cognitive impairment could be a task for future studies. SN - 0720-4299 UR - https://www.unboundmedicine.com/medline/citation/17607642/[Validation_of_a_short_test__3MS_R__for_detecting_Alzheimer's_disease]_ L2 - http://www.thieme-connect.com/DOI/DOI?10.1055/s-2007-980062 DB - PRIME DP - Unbound Medicine ER -