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Treatment of acute gout in hospitalized patients.
J Rheumatol. 2007 Jul; 34(7):1566-8.JR

Abstract

OBJECTIVE

To record practice patterns of treatment of acute gout in hospitalized patients.

METHODS

We performed a retrospective chart review of hospitalized patients diagnosed with gout.

RESULTS

Seventy-nine (43%) patients were diagnosed with acute gout during their hospitalization. Fifty-eight (73%) patients with acute gout were found to have a reduction in their glomerular filtration rate. Twenty patients (25%) underwent arthrocentesis. The most widely used drugs for acute gout were colchicine, n = 42 (53%), and nonsteroidal antiinflammatory drugs (NSAID), n = 40 (51%). Combination therapy was used in 52% of patients with acute gout. Thiry-six (86%) patients treated with colchicine and 32 (80%) patients treated with NSAID had renal failure.

DISCUSSION

Crystal analysis, the gold standard for diagnosing gout, was performed in only 25% of patients suspected of acute gout. Combination antiinflammatory agents are used in over 50% of patients despite the absence of evidence to support use of such combinations. Renal failure was present in 73% of patients with acute gout. Colchicine and NSAID should therefore be used with caution in these patients. Practice patterns vary widely and often appear to be in conflict with recommended diagnostic and treatment measures for acute gout.

Authors+Show Affiliations

Petersel D
Rheumatology Division, Department of Medicine, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, New Brunswick, New Jersey 08903-0019, USA.
Schlesinger N
No affiliation info available

MeSH

Acute DiseaseAdultAgedAged, 80 and overAllopurinolAnti-Inflammatory Agents, Non-SteroidalChronic DiseaseColchicineDrug Therapy, CombinationGoutGout SuppressantsHospitalizationHumansMaleMiddle AgedPractice Patterns, Physicians'Renal InsufficiencyRetrospective Studies

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17610315

Citation

Petersel, Danielle, and Naomi Schlesinger. "Treatment of Acute Gout in Hospitalized Patients." The Journal of Rheumatology, vol. 34, no. 7, 2007, pp. 1566-8.
Petersel D, Schlesinger N. Treatment of acute gout in hospitalized patients. J Rheumatol. 2007;34(7):1566-8.
Petersel, D., & Schlesinger, N. (2007). Treatment of acute gout in hospitalized patients. The Journal of Rheumatology, 34(7), 1566-8.
Petersel D, Schlesinger N. Treatment of Acute Gout in Hospitalized Patients. J Rheumatol. 2007;34(7):1566-8. PubMed PMID: 17610315.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Treatment of acute gout in hospitalized patients. AU - Petersel,Danielle, AU - Schlesinger,Naomi, Y1 - 2007/06/15/ PY - 2007/7/5/pubmed PY - 2007/8/19/medline PY - 2007/7/5/entrez SP - 1566 EP - 8 JF - The Journal of rheumatology JO - J Rheumatol VL - 34 IS - 7 N2 - OBJECTIVE: To record practice patterns of treatment of acute gout in hospitalized patients. METHODS: We performed a retrospective chart review of hospitalized patients diagnosed with gout. RESULTS: Seventy-nine (43%) patients were diagnosed with acute gout during their hospitalization. Fifty-eight (73%) patients with acute gout were found to have a reduction in their glomerular filtration rate. Twenty patients (25%) underwent arthrocentesis. The most widely used drugs for acute gout were colchicine, n = 42 (53%), and nonsteroidal antiinflammatory drugs (NSAID), n = 40 (51%). Combination therapy was used in 52% of patients with acute gout. Thiry-six (86%) patients treated with colchicine and 32 (80%) patients treated with NSAID had renal failure. DISCUSSION: Crystal analysis, the gold standard for diagnosing gout, was performed in only 25% of patients suspected of acute gout. Combination antiinflammatory agents are used in over 50% of patients despite the absence of evidence to support use of such combinations. Renal failure was present in 73% of patients with acute gout. Colchicine and NSAID should therefore be used with caution in these patients. Practice patterns vary widely and often appear to be in conflict with recommended diagnostic and treatment measures for acute gout. SN - 0315-162X UR - https://www.unboundmedicine.com/medline/citation/17610315/Treatment_of_acute_gout_in_hospitalized_patients_ DB - PRIME DP - Unbound Medicine ER -