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Reduced mitochondrial coenzyme Q10 levels in HepG2 cells treated with high-dose simvastatin: a possible role in statin-induced hepatotoxicity?
Toxicol Appl Pharmacol. 2007 Sep 01; 223(2):173-9.TA

Abstract

Lowering of low-density lipoprotein cholesterol is well achieved by 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors (statins). Statins inhibit the conversion of HMG-CoA to mevalonate, a precursor for cholesterol and coenzyme Q10 (CoQ10). In HepG2 cells, simvastatin decreased mitochondrial CoQ10 levels, and at higher concentrations was associated with a moderately higher degree of cell death, increased DNA oxidative damage and a reduction in ATP synthesis. Supplementation of CoQ10, reduced cell death and DNA oxidative stress, and increased ATP synthesis. It is suggested that CoQ10 deficiency plays an important role in statin-induced hepatopathy, and that CoQ10 supplementation protects HepG2 cells from this complication.

Authors+Show Affiliations

Department of Medicine, Alexandra Hospital, and Department of Community, Occupational and Family Medicine, Yong Loo Lin School of Medicine, Singapore. tavintharan_subramaniam@alexhosp.com.sgNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17610923

Citation

Tavintharan, S, et al. "Reduced Mitochondrial Coenzyme Q10 Levels in HepG2 Cells Treated With High-dose Simvastatin: a Possible Role in Statin-induced Hepatotoxicity?" Toxicology and Applied Pharmacology, vol. 223, no. 2, 2007, pp. 173-9.
Tavintharan S, Ong CN, Jeyaseelan K, et al. Reduced mitochondrial coenzyme Q10 levels in HepG2 cells treated with high-dose simvastatin: a possible role in statin-induced hepatotoxicity? Toxicol Appl Pharmacol. 2007;223(2):173-9.
Tavintharan, S., Ong, C. N., Jeyaseelan, K., Sivakumar, M., Lim, S. C., & Sum, C. F. (2007). Reduced mitochondrial coenzyme Q10 levels in HepG2 cells treated with high-dose simvastatin: a possible role in statin-induced hepatotoxicity? Toxicology and Applied Pharmacology, 223(2), 173-9.
Tavintharan S, et al. Reduced Mitochondrial Coenzyme Q10 Levels in HepG2 Cells Treated With High-dose Simvastatin: a Possible Role in Statin-induced Hepatotoxicity. Toxicol Appl Pharmacol. 2007 Sep 1;223(2):173-9. PubMed PMID: 17610923.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Reduced mitochondrial coenzyme Q10 levels in HepG2 cells treated with high-dose simvastatin: a possible role in statin-induced hepatotoxicity? AU - Tavintharan,S, AU - Ong,C N, AU - Jeyaseelan,K, AU - Sivakumar,M, AU - Lim,S C, AU - Sum,C F, Y1 - 2007/05/26/ PY - 2007/03/08/received PY - 2007/05/11/revised PY - 2007/05/17/accepted PY - 2007/7/6/pubmed PY - 2007/10/31/medline PY - 2007/7/6/entrez SP - 173 EP - 9 JF - Toxicology and applied pharmacology JO - Toxicol. Appl. Pharmacol. VL - 223 IS - 2 N2 - Lowering of low-density lipoprotein cholesterol is well achieved by 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors (statins). Statins inhibit the conversion of HMG-CoA to mevalonate, a precursor for cholesterol and coenzyme Q10 (CoQ10). In HepG2 cells, simvastatin decreased mitochondrial CoQ10 levels, and at higher concentrations was associated with a moderately higher degree of cell death, increased DNA oxidative damage and a reduction in ATP synthesis. Supplementation of CoQ10, reduced cell death and DNA oxidative stress, and increased ATP synthesis. It is suggested that CoQ10 deficiency plays an important role in statin-induced hepatopathy, and that CoQ10 supplementation protects HepG2 cells from this complication. SN - 0041-008X UR - https://www.unboundmedicine.com/medline/citation/17610923/Reduced_mitochondrial_coenzyme_Q10_levels_in_HepG2_cells_treated_with_high_dose_simvastatin:_a_possible_role_in_statin_induced_hepatotoxicity L2 - https://linkinghub.elsevier.com/retrieve/pii/S0041-008X(07)00241-4 DB - PRIME DP - Unbound Medicine ER -