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Nutritional intervention in brain aging: reducing the effects of inflammation and oxidative stress.
Subcell Biochem. 2007; 42:299-318.SB

Abstract

It is estimated that by the year 2050 the elderly (aged 65 or older) population will double the population of children (aged 0-14) for the first time in history. The expansion of the elderly population has already taken a toll on health care systems. In order to alleviate the health care costs and increase the quality of living in the aging population, it is crucial to explore methods that may retard or reverse the deleterious effects of aging. Inflammation and oxidative stress play important roles in brain aging. Inflammatory markers, as well as cellular and molecular oxidative damage, increase during normal brain aging. This increase is accompanied by the concomitant decline in cognitive and motor performance in the elderly population, even in the absence of neurodegenerative diseases. Epidemiological studies have shown that consumption of diets rich in antioxidant and anti-inflammatory agents, such as those found in fruits and vegetables, may lower the risk of developing age-related neurodegenerative diseases such as Parkinson's disease and Alzheimer's disease. Research from our laboratory suggests that dietary supplementation with fruit or vegetable extracts can decrease the age-enhanced vulnerability to oxidative stress and inflammation. Additional research suggests that the polyphenolic compounds found in fruits such as blueberries may exert their beneficial effects through signal transduction and neuronal communication. Thus, nutritional intervention may exert therapeutic protection against age-related deficits and neurodegenerative diseases.

Authors+Show Affiliations

USDA-ARS, Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

17612057

Citation

Lau, Francis C., et al. "Nutritional Intervention in Brain Aging: Reducing the Effects of Inflammation and Oxidative Stress." Sub-cellular Biochemistry, vol. 42, 2007, pp. 299-318.
Lau FC, Shukitt-Hale B, Joseph JA. Nutritional intervention in brain aging: reducing the effects of inflammation and oxidative stress. Subcell Biochem. 2007;42:299-318.
Lau, F. C., Shukitt-Hale, B., & Joseph, J. A. (2007). Nutritional intervention in brain aging: reducing the effects of inflammation and oxidative stress. Sub-cellular Biochemistry, 42, 299-318.
Lau FC, Shukitt-Hale B, Joseph JA. Nutritional Intervention in Brain Aging: Reducing the Effects of Inflammation and Oxidative Stress. Subcell Biochem. 2007;42:299-318. PubMed PMID: 17612057.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Nutritional intervention in brain aging: reducing the effects of inflammation and oxidative stress. AU - Lau,Francis C, AU - Shukitt-Hale,Barbara, AU - Joseph,James A, PY - 2007/7/7/pubmed PY - 2007/8/7/medline PY - 2007/7/7/entrez SP - 299 EP - 318 JF - Sub-cellular biochemistry JO - Subcell Biochem VL - 42 N2 - It is estimated that by the year 2050 the elderly (aged 65 or older) population will double the population of children (aged 0-14) for the first time in history. The expansion of the elderly population has already taken a toll on health care systems. In order to alleviate the health care costs and increase the quality of living in the aging population, it is crucial to explore methods that may retard or reverse the deleterious effects of aging. Inflammation and oxidative stress play important roles in brain aging. Inflammatory markers, as well as cellular and molecular oxidative damage, increase during normal brain aging. This increase is accompanied by the concomitant decline in cognitive and motor performance in the elderly population, even in the absence of neurodegenerative diseases. Epidemiological studies have shown that consumption of diets rich in antioxidant and anti-inflammatory agents, such as those found in fruits and vegetables, may lower the risk of developing age-related neurodegenerative diseases such as Parkinson's disease and Alzheimer's disease. Research from our laboratory suggests that dietary supplementation with fruit or vegetable extracts can decrease the age-enhanced vulnerability to oxidative stress and inflammation. Additional research suggests that the polyphenolic compounds found in fruits such as blueberries may exert their beneficial effects through signal transduction and neuronal communication. Thus, nutritional intervention may exert therapeutic protection against age-related deficits and neurodegenerative diseases. SN - 0306-0225 UR - https://www.unboundmedicine.com/medline/citation/17612057/Nutritional_intervention_in_brain_aging:_reducing_the_effects_of_inflammation_and_oxidative_stress_ L2 - https://medlineplus.gov/olderadulthealth.html DB - PRIME DP - Unbound Medicine ER -