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Abnormal humoral immune response to influenza vaccination in pediatric type-1 human immunodeficiency virus infected patients receiving highly active antiretroviral therapy.
Mem Inst Oswaldo Cruz 2007; 102(4):501-8MI

Abstract

Given that highly active antiretroviral therapy (HAART) has been demonstrated useful to restore immune competence in type-1 human immunodeficiency virus (HIV-1)-infected subjects, we evaluated the specific antibody response to influenza vaccine in a cohort of HIV-1-infected children on HAART so as to analyze the quality of this immune response in patients under antiretroviral therapy. Sixteen HIV-1-infected children and 10 HIV-1 seronegative controls were immunized with a commercially available trivalent inactivated influenza vaccine containing the strains A/H1N1, A/H3N2, and B. Serum hemagglutinin inhibition (HI) antibody titers were determined for the three viral strains at the time of vaccination and 1 month later. Immunization induced a significantly increased humoral response against the three influenza virus strains in controls, and only against A/H3N2 in HIV-1-infected children. The comparison of post-vaccination HI titers between HIV-1+ patients and HIV-1 negative controls showed significantly higher HI titers against the three strains in controls. In addition, post vaccination protective HI titers (defined as equal to or higher than 1:40) against the strains A/H3N2 and B were observed in a lower proportion of HIV-1+ children than in controls, while a similar proportion of individuals from each group achieved protective HI titers against the A/H1N1 strain. The CD4+ T cell count, CD4/CD8 T cells ratio, and serum viral load were not affected by influenza virus vaccination when pre- vs post-vaccination values were compared. These findings suggest that despite the fact that HAART is efficient in controlling HIV-1 replication and in increasing CD4+ T cell count in HIV-1-infected children, restoration of immune competence and response to cognate antigens remain incomplete, indicating that additional therapeutic strategies are required to achieve a full reconstitution of immune functions.

Authors+Show Affiliations

Group of Immunovirology-Biogenesis, Universidad de Antioquia, Medellin, Columbia. cjmonto@une.net.coNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17612772

Citation

Montoya, Carlos J., et al. "Abnormal Humoral Immune Response to Influenza Vaccination in Pediatric Type-1 Human Immunodeficiency Virus Infected Patients Receiving Highly Active Antiretroviral Therapy." Memorias Do Instituto Oswaldo Cruz, vol. 102, no. 4, 2007, pp. 501-8.
Montoya CJ, Toro MF, Aguirre C, et al. Abnormal humoral immune response to influenza vaccination in pediatric type-1 human immunodeficiency virus infected patients receiving highly active antiretroviral therapy. Mem Inst Oswaldo Cruz. 2007;102(4):501-8.
Montoya, C. J., Toro, M. F., Aguirre, C., Bustamante, A., Hernandez, M., Arango, L. P., ... Rojas, M. (2007). Abnormal humoral immune response to influenza vaccination in pediatric type-1 human immunodeficiency virus infected patients receiving highly active antiretroviral therapy. Memorias Do Instituto Oswaldo Cruz, 102(4), pp. 501-8.
Montoya CJ, et al. Abnormal Humoral Immune Response to Influenza Vaccination in Pediatric Type-1 Human Immunodeficiency Virus Infected Patients Receiving Highly Active Antiretroviral Therapy. Mem Inst Oswaldo Cruz. 2007;102(4):501-8. PubMed PMID: 17612772.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Abnormal humoral immune response to influenza vaccination in pediatric type-1 human immunodeficiency virus infected patients receiving highly active antiretroviral therapy. AU - Montoya,Carlos J, AU - Toro,Maria F, AU - Aguirre,Carlos, AU - Bustamante,Alberto, AU - Hernandez,Mariluz, AU - Arango,Liliana P, AU - Echeverry,Marta, AU - Arango,Ana E, AU - Prada,Maria C, AU - Alarcon,Herminia del P, AU - Rojas,Mauricio, PY - 2006/11/29/received PY - 2007/04/19/accepted PY - 2007/7/7/pubmed PY - 2008/1/12/medline PY - 2007/7/7/entrez SP - 501 EP - 8 JF - Memorias do Instituto Oswaldo Cruz JO - Mem. Inst. Oswaldo Cruz VL - 102 IS - 4 N2 - Given that highly active antiretroviral therapy (HAART) has been demonstrated useful to restore immune competence in type-1 human immunodeficiency virus (HIV-1)-infected subjects, we evaluated the specific antibody response to influenza vaccine in a cohort of HIV-1-infected children on HAART so as to analyze the quality of this immune response in patients under antiretroviral therapy. Sixteen HIV-1-infected children and 10 HIV-1 seronegative controls were immunized with a commercially available trivalent inactivated influenza vaccine containing the strains A/H1N1, A/H3N2, and B. Serum hemagglutinin inhibition (HI) antibody titers were determined for the three viral strains at the time of vaccination and 1 month later. Immunization induced a significantly increased humoral response against the three influenza virus strains in controls, and only against A/H3N2 in HIV-1-infected children. The comparison of post-vaccination HI titers between HIV-1+ patients and HIV-1 negative controls showed significantly higher HI titers against the three strains in controls. In addition, post vaccination protective HI titers (defined as equal to or higher than 1:40) against the strains A/H3N2 and B were observed in a lower proportion of HIV-1+ children than in controls, while a similar proportion of individuals from each group achieved protective HI titers against the A/H1N1 strain. The CD4+ T cell count, CD4/CD8 T cells ratio, and serum viral load were not affected by influenza virus vaccination when pre- vs post-vaccination values were compared. These findings suggest that despite the fact that HAART is efficient in controlling HIV-1 replication and in increasing CD4+ T cell count in HIV-1-infected children, restoration of immune competence and response to cognate antigens remain incomplete, indicating that additional therapeutic strategies are required to achieve a full reconstitution of immune functions. SN - 0074-0276 UR - https://www.unboundmedicine.com/medline/citation/17612772/Abnormal_humoral_immune_response_to_influenza_vaccination_in_pediatric_type_1_human_immunodeficiency_virus_infected_patients_receiving_highly_active_antiretroviral_therapy_ L2 - http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762007000400012&lng=en&nrm=iso&tlng=en DB - PRIME DP - Unbound Medicine ER -