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Abnormal humoral immune response to influenza vaccination in pediatric type-1 human immunodeficiency virus infected patients receiving highly active antiretroviral therapy.

Abstract

Given that highly active antiretroviral therapy (HAART) has been demonstrated useful to restore immune competence in type-1 human immunodeficiency virus (HIV-1)-infected subjects, we evaluated the specific antibody response to influenza vaccine in a cohort of HIV-1-infected children on HAART so as to analyze the quality of this immune response in patients under antiretroviral therapy. Sixteen HIV-1-infected children and 10 HIV-1 seronegative controls were immunized with a commercially available trivalent inactivated influenza vaccine containing the strains A/H1N1, A/H3N2, and B. Serum hemagglutinin inhibition (HI) antibody titers were determined for the three viral strains at the time of vaccination and 1 month later. Immunization induced a significantly increased humoral response against the three influenza virus strains in controls, and only against A/H3N2 in HIV-1-infected children. The comparison of post-vaccination HI titers between HIV-1+ patients and HIV-1 negative controls showed significantly higher HI titers against the three strains in controls. In addition, post vaccination protective HI titers (defined as equal to or higher than 1:40) against the strains A/H3N2 and B were observed in a lower proportion of HIV-1+ children than in controls, while a similar proportion of individuals from each group achieved protective HI titers against the A/H1N1 strain. The CD4+ T cell count, CD4/CD8 T cells ratio, and serum viral load were not affected by influenza virus vaccination when pre- vs post-vaccination values were compared. These findings suggest that despite the fact that HAART is efficient in controlling HIV-1 replication and in increasing CD4+ T cell count in HIV-1-infected children, restoration of immune competence and response to cognate antigens remain incomplete, indicating that additional therapeutic strategies are required to achieve a full reconstitution of immune functions.

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  • Authors+Show Affiliations

    ,

    Group of Immunovirology-Biogenesis, Universidad de Antioquia, Medellin, Columbia. cjmonto@une.net.co

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    Source

    Memorias do Instituto Oswaldo Cruz 102:4 2007 Jun pg 501-8

    MeSH

    Antibodies, Viral
    Antiretroviral Therapy, Highly Active
    CD4 Lymphocyte Count
    Case-Control Studies
    Child
    Child, Preschool
    Cohort Studies
    Female
    HIV Infections
    HIV-1
    Humans
    Influenza A virus
    Influenza B virus
    Influenza Vaccines
    Influenza, Human
    Male
    Vaccines, Inactivated
    Viral Load

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    17612772

    Citation

    Montoya, Carlos J., et al. "Abnormal Humoral Immune Response to Influenza Vaccination in Pediatric Type-1 Human Immunodeficiency Virus Infected Patients Receiving Highly Active Antiretroviral Therapy." Memorias Do Instituto Oswaldo Cruz, vol. 102, no. 4, 2007, pp. 501-8.
    Montoya CJ, Toro MF, Aguirre C, et al. Abnormal humoral immune response to influenza vaccination in pediatric type-1 human immunodeficiency virus infected patients receiving highly active antiretroviral therapy. Mem Inst Oswaldo Cruz. 2007;102(4):501-8.
    Montoya, C. J., Toro, M. F., Aguirre, C., Bustamante, A., Hernandez, M., Arango, L. P., ... Rojas, M. (2007). Abnormal humoral immune response to influenza vaccination in pediatric type-1 human immunodeficiency virus infected patients receiving highly active antiretroviral therapy. Memorias Do Instituto Oswaldo Cruz, 102(4), pp. 501-8.
    Montoya CJ, et al. Abnormal Humoral Immune Response to Influenza Vaccination in Pediatric Type-1 Human Immunodeficiency Virus Infected Patients Receiving Highly Active Antiretroviral Therapy. Mem Inst Oswaldo Cruz. 2007;102(4):501-8. PubMed PMID: 17612772.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Abnormal humoral immune response to influenza vaccination in pediatric type-1 human immunodeficiency virus infected patients receiving highly active antiretroviral therapy. AU - Montoya,Carlos J, AU - Toro,Maria F, AU - Aguirre,Carlos, AU - Bustamante,Alberto, AU - Hernandez,Mariluz, AU - Arango,Liliana P, AU - Echeverry,Marta, AU - Arango,Ana E, AU - Prada,Maria C, AU - Alarcon,Herminia del P, AU - Rojas,Mauricio, PY - 2006/11/29/received PY - 2007/04/19/accepted PY - 2007/7/7/pubmed PY - 2008/1/12/medline PY - 2007/7/7/entrez SP - 501 EP - 8 JF - Memorias do Instituto Oswaldo Cruz JO - Mem. Inst. Oswaldo Cruz VL - 102 IS - 4 N2 - Given that highly active antiretroviral therapy (HAART) has been demonstrated useful to restore immune competence in type-1 human immunodeficiency virus (HIV-1)-infected subjects, we evaluated the specific antibody response to influenza vaccine in a cohort of HIV-1-infected children on HAART so as to analyze the quality of this immune response in patients under antiretroviral therapy. Sixteen HIV-1-infected children and 10 HIV-1 seronegative controls were immunized with a commercially available trivalent inactivated influenza vaccine containing the strains A/H1N1, A/H3N2, and B. Serum hemagglutinin inhibition (HI) antibody titers were determined for the three viral strains at the time of vaccination and 1 month later. Immunization induced a significantly increased humoral response against the three influenza virus strains in controls, and only against A/H3N2 in HIV-1-infected children. The comparison of post-vaccination HI titers between HIV-1+ patients and HIV-1 negative controls showed significantly higher HI titers against the three strains in controls. In addition, post vaccination protective HI titers (defined as equal to or higher than 1:40) against the strains A/H3N2 and B were observed in a lower proportion of HIV-1+ children than in controls, while a similar proportion of individuals from each group achieved protective HI titers against the A/H1N1 strain. The CD4+ T cell count, CD4/CD8 T cells ratio, and serum viral load were not affected by influenza virus vaccination when pre- vs post-vaccination values were compared. These findings suggest that despite the fact that HAART is efficient in controlling HIV-1 replication and in increasing CD4+ T cell count in HIV-1-infected children, restoration of immune competence and response to cognate antigens remain incomplete, indicating that additional therapeutic strategies are required to achieve a full reconstitution of immune functions. SN - 0074-0276 UR - https://www.unboundmedicine.com/medline/citation/17612772/Abnormal_humoral_immune_response_to_influenza_vaccination_in_pediatric_type_1_human_immunodeficiency_virus_infected_patients_receiving_highly_active_antiretroviral_therapy_ L2 - http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762007000400012&lng=en&nrm=iso&tlng=en DB - PRIME DP - Unbound Medicine ER -