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Sustained-release from layered matrix system comprising chitosan and xanthan gum.
Drug Dev Ind Pharm. 2007 Jun; 33(6):595-605.DD

Abstract

Sustained-release tablets of propranolol HCl were prepared by direct compression using chitosan and xanthan gum as matrix materials. The effective prolongation of drug release in acidic environment was achieved for matrix containing chitosan together with xanthan gum which prolonged the drug release more extensive than that containing single polymer. Increasing lactose into matrix could adjust the drug release characteristic by enhancing the drug released. Component containing chitosan and xanthan gum at ratio 1:1 and lactose 75% w/w was selected for preparing the layered matrix by tabletting. Increasing the amount of matrix in barrier or in middle layer resulted in prolongation of drug release. From the investigation of drug release from one planar surface, the lag time for drug release through barrier layer was apparently longer as the amount of barrier was enhanced. Least square fitting the experimental dissolution data to the mathematical expressions (power law, first order, Higuchi's and zero order) was performed to study the drug release mechanism. Layering with polymeric matrix could prolong the drug release and could shift the release pattern approach to zero order. The drug release from chitosan-xanthan gum three-layer tablet was pH dependent due to the difference in charge density in different environmental pH. FT-IR and DSC studies exhibited the charge interaction between of NH3+ of chitosan molecule and COO- of acetate or pyruvate groups of xanthan gum molecule. The SEM images revealed the formation of the loose membranous but porous film that was due to the gel layer formed by the polymer relaxation upon absorption of dissolution medium. The decreased rate of polymer dissolution resulting from the decreased rate of solvent penetration was accompanied by a decrease in drug diffusion due to ionic interaction between chitosan and xanthan gum. This was suggested that the utilization of chitosan and xanthan gum could give rise to layered matrix tablet exhibiting sustained drug release.

Authors+Show Affiliations

Department of Pharmaceutical Technology, Faculty of Pharmacy, Silpakorn University, Nakorn Pathom, Thailand. thawatchai@emial.pharm.su.sc.thNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17613024

Citation

Phaechamud, Thawatchai, and Garnpimol C. Ritthidej. "Sustained-release From Layered Matrix System Comprising Chitosan and Xanthan Gum." Drug Development and Industrial Pharmacy, vol. 33, no. 6, 2007, pp. 595-605.
Phaechamud T, Ritthidej GC. Sustained-release from layered matrix system comprising chitosan and xanthan gum. Drug Dev Ind Pharm. 2007;33(6):595-605.
Phaechamud, T., & Ritthidej, G. C. (2007). Sustained-release from layered matrix system comprising chitosan and xanthan gum. Drug Development and Industrial Pharmacy, 33(6), 595-605.
Phaechamud T, Ritthidej GC. Sustained-release From Layered Matrix System Comprising Chitosan and Xanthan Gum. Drug Dev Ind Pharm. 2007;33(6):595-605. PubMed PMID: 17613024.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Sustained-release from layered matrix system comprising chitosan and xanthan gum. AU - Phaechamud,Thawatchai, AU - Ritthidej,Garnpimol C, PY - 2007/7/7/pubmed PY - 2007/9/29/medline PY - 2007/7/7/entrez SP - 595 EP - 605 JF - Drug development and industrial pharmacy JO - Drug Dev Ind Pharm VL - 33 IS - 6 N2 - Sustained-release tablets of propranolol HCl were prepared by direct compression using chitosan and xanthan gum as matrix materials. The effective prolongation of drug release in acidic environment was achieved for matrix containing chitosan together with xanthan gum which prolonged the drug release more extensive than that containing single polymer. Increasing lactose into matrix could adjust the drug release characteristic by enhancing the drug released. Component containing chitosan and xanthan gum at ratio 1:1 and lactose 75% w/w was selected for preparing the layered matrix by tabletting. Increasing the amount of matrix in barrier or in middle layer resulted in prolongation of drug release. From the investigation of drug release from one planar surface, the lag time for drug release through barrier layer was apparently longer as the amount of barrier was enhanced. Least square fitting the experimental dissolution data to the mathematical expressions (power law, first order, Higuchi's and zero order) was performed to study the drug release mechanism. Layering with polymeric matrix could prolong the drug release and could shift the release pattern approach to zero order. The drug release from chitosan-xanthan gum three-layer tablet was pH dependent due to the difference in charge density in different environmental pH. FT-IR and DSC studies exhibited the charge interaction between of NH3+ of chitosan molecule and COO- of acetate or pyruvate groups of xanthan gum molecule. The SEM images revealed the formation of the loose membranous but porous film that was due to the gel layer formed by the polymer relaxation upon absorption of dissolution medium. The decreased rate of polymer dissolution resulting from the decreased rate of solvent penetration was accompanied by a decrease in drug diffusion due to ionic interaction between chitosan and xanthan gum. This was suggested that the utilization of chitosan and xanthan gum could give rise to layered matrix tablet exhibiting sustained drug release. SN - 0363-9045 UR - https://www.unboundmedicine.com/medline/citation/17613024/Sustained_release_from_layered_matrix_system_comprising_chitosan_and_xanthan_gum_ L2 - https://www.tandfonline.com/doi/full/10.1080/03639040601015521 DB - PRIME DP - Unbound Medicine ER -