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Studies on lignan constituents from Schisandra chinensis (Turcz.) Baill. fruits using high-performance liquid chromatography/electrospray ionization multiple-stage tandem mass spectrometry.
J Mass Spectrom. 2007 Sep; 42(9):1148-61.JM

Abstract

A reversed-phase high-performance liquid chromatography-diode array detector-electrospray ionization multiple-stage tandem mass spectrometry (RP-HPLC-DAD-ESI-MS(n)) method has been developed for the detection and analysis of lignan constituents in the methanol extract from the fruits of Schisandra chinensis (Turcz.) Baill. RP-HPLC-DAD-ESI-MS(n) and electrospray ionization Fourier transform ion cyclotron resonance multiple-stage tandem mass spectrometry (ESI-FT-ICR-MS(n)) have been applied to investigate the characteristic product ions of four lignan reference compounds. Then, the logical fragmentation pathways of the lignans have been proposed. By comparing the retention time (t(R)) of HPLC, the ESI-MS(n) data and the structures of analyzed compounds with the data of reference compounds and in the literature, 11 peaks in HPLC have been unambiguously identified and another 5 peaks have been tentatively identified or deduced. Also, in the present paper, the extracted ion chromatograms (EIC) have been used to analyze the lignan isomers. The experimental results demonstrate that RP-HPLC-DAD-ESI-MS(n) is a specific and useful method for the identification of the lignan constituents and their isomers.

Authors+Show Affiliations

Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun Center of Mass Spectrometry, Changchun, PR China.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17613177

Citation

Huang, Xin, et al. "Studies On Lignan Constituents From Schisandra Chinensis (Turcz.) Baill. Fruits Using High-performance Liquid Chromatography/electrospray Ionization Multiple-stage Tandem Mass Spectrometry." Journal of Mass Spectrometry : JMS, vol. 42, no. 9, 2007, pp. 1148-61.
Huang X, Song F, Liu Z, et al. Studies on lignan constituents from Schisandra chinensis (Turcz.) Baill. fruits using high-performance liquid chromatography/electrospray ionization multiple-stage tandem mass spectrometry. J Mass Spectrom. 2007;42(9):1148-61.
Huang, X., Song, F., Liu, Z., & Liu, S. (2007). Studies on lignan constituents from Schisandra chinensis (Turcz.) Baill. fruits using high-performance liquid chromatography/electrospray ionization multiple-stage tandem mass spectrometry. Journal of Mass Spectrometry : JMS, 42(9), 1148-61.
Huang X, et al. Studies On Lignan Constituents From Schisandra Chinensis (Turcz.) Baill. Fruits Using High-performance Liquid Chromatography/electrospray Ionization Multiple-stage Tandem Mass Spectrometry. J Mass Spectrom. 2007;42(9):1148-61. PubMed PMID: 17613177.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Studies on lignan constituents from Schisandra chinensis (Turcz.) Baill. fruits using high-performance liquid chromatography/electrospray ionization multiple-stage tandem mass spectrometry. AU - Huang,Xin, AU - Song,Fengrui, AU - Liu,Zhiqiang, AU - Liu,Shuying, PY - 2007/7/7/pubmed PY - 2007/10/25/medline PY - 2007/7/7/entrez SP - 1148 EP - 61 JF - Journal of mass spectrometry : JMS JO - J Mass Spectrom VL - 42 IS - 9 N2 - A reversed-phase high-performance liquid chromatography-diode array detector-electrospray ionization multiple-stage tandem mass spectrometry (RP-HPLC-DAD-ESI-MS(n)) method has been developed for the detection and analysis of lignan constituents in the methanol extract from the fruits of Schisandra chinensis (Turcz.) Baill. RP-HPLC-DAD-ESI-MS(n) and electrospray ionization Fourier transform ion cyclotron resonance multiple-stage tandem mass spectrometry (ESI-FT-ICR-MS(n)) have been applied to investigate the characteristic product ions of four lignan reference compounds. Then, the logical fragmentation pathways of the lignans have been proposed. By comparing the retention time (t(R)) of HPLC, the ESI-MS(n) data and the structures of analyzed compounds with the data of reference compounds and in the literature, 11 peaks in HPLC have been unambiguously identified and another 5 peaks have been tentatively identified or deduced. Also, in the present paper, the extracted ion chromatograms (EIC) have been used to analyze the lignan isomers. The experimental results demonstrate that RP-HPLC-DAD-ESI-MS(n) is a specific and useful method for the identification of the lignan constituents and their isomers. SN - 1076-5174 UR - https://www.unboundmedicine.com/medline/citation/17613177/Studies_on_lignan_constituents_from_Schisandra_chinensis__Turcz___Baill__fruits_using_high_performance_liquid_chromatography/electrospray_ionization_multiple_stage_tandem_mass_spectrometry_ L2 - https://doi.org/10.1002/jms.1246 DB - PRIME DP - Unbound Medicine ER -