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A new flavonol glycoside and activity of compounds from the flower of Nymphaea candida.
J Asian Nat Prod Res. 2007 Apr-Aug; 9(3-5):333-8.JA

Abstract

A new compound, kaempferol 3-O-(2''-O-galloylrutinoside) (1), was isolated from the white flower of Nymphaea candida, together with nine known flavonol glycosides, kaempferol (2), kaempferol 3-O-beta-D-glucopyranoside (3), kaempferol 3-O-alpha-l-rhamnopyranoside (4), kaempferol 3-O-alpha-l-rhamnopyranosylglucopyranoside (5), kaempferol 7-O-beta-D-glucopyranoside 3-(O-alpha-l-rhamnopyranosylglucopyranoside) (6), quercetin (7), quercetin 3-O-beta-D-xylopyranoside (8), myricetin (9), myricetin 3'-O-beta-D-xylopyranoside (10). The structure of 1 was established on the basis of the analysis of its 1D and 2D NMR spectral data. Compounds 1-7 and 9 exhibited moderate to significant antioxidant activities, which were evaluated by measurement of low-density lipoprotein (LDL) and malondialdehyde (MDA) levels in vitro. Compounds 1, 3, 4, 6 and 9 exhibited promising neuroprotective effects on ischemic injury model of cultured rat cortical neurons treated with sodium dithionite in glucose-free medium. Furthermore, compounds 1, 5, and 9 had distinct cytotoxicity to adrenal gland pheochromocytoma, PC12 cells, being treated by the same way.

Authors+Show Affiliations

Laboratory of Pharmaceutical Sciences, Department of Biological Sciences and Biotechnology, Tsinghua University, Beijing 100084, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17613618

Citation

Liu, R-N, et al. "A New Flavonol Glycoside and Activity of Compounds From the Flower of Nymphaea Candida." Journal of Asian Natural Products Research, vol. 9, no. 3-5, 2007, pp. 333-8.
Liu RN, Wang W, Ding Y, et al. A new flavonol glycoside and activity of compounds from the flower of Nymphaea candida. J Asian Nat Prod Res. 2007;9(3-5):333-8.
Liu, R. N., Wang, W., Ding, Y., Xie, W. D., Ma, C., & Du, L. J. (2007). A new flavonol glycoside and activity of compounds from the flower of Nymphaea candida. Journal of Asian Natural Products Research, 9(3-5), 333-8.
Liu RN, et al. A New Flavonol Glycoside and Activity of Compounds From the Flower of Nymphaea Candida. J Asian Nat Prod Res. 2007 Apr-Aug;9(3-5):333-8. PubMed PMID: 17613618.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A new flavonol glycoside and activity of compounds from the flower of Nymphaea candida. AU - Liu,R-N, AU - Wang,W, AU - Ding,Y, AU - Xie,W-D, AU - Ma,C, AU - Du,L-J, PY - 2007/7/7/pubmed PY - 2008/1/4/medline PY - 2007/7/7/entrez SP - 333 EP - 8 JF - Journal of Asian natural products research JO - J Asian Nat Prod Res VL - 9 IS - 3-5 N2 - A new compound, kaempferol 3-O-(2''-O-galloylrutinoside) (1), was isolated from the white flower of Nymphaea candida, together with nine known flavonol glycosides, kaempferol (2), kaempferol 3-O-beta-D-glucopyranoside (3), kaempferol 3-O-alpha-l-rhamnopyranoside (4), kaempferol 3-O-alpha-l-rhamnopyranosylglucopyranoside (5), kaempferol 7-O-beta-D-glucopyranoside 3-(O-alpha-l-rhamnopyranosylglucopyranoside) (6), quercetin (7), quercetin 3-O-beta-D-xylopyranoside (8), myricetin (9), myricetin 3'-O-beta-D-xylopyranoside (10). The structure of 1 was established on the basis of the analysis of its 1D and 2D NMR spectral data. Compounds 1-7 and 9 exhibited moderate to significant antioxidant activities, which were evaluated by measurement of low-density lipoprotein (LDL) and malondialdehyde (MDA) levels in vitro. Compounds 1, 3, 4, 6 and 9 exhibited promising neuroprotective effects on ischemic injury model of cultured rat cortical neurons treated with sodium dithionite in glucose-free medium. Furthermore, compounds 1, 5, and 9 had distinct cytotoxicity to adrenal gland pheochromocytoma, PC12 cells, being treated by the same way. SN - 1028-6020 UR - https://www.unboundmedicine.com/medline/citation/17613618/A_new_flavonol_glycoside_and_activity_of_compounds_from_the_flower_of_Nymphaea_candida_ L2 - https://www.tandfonline.com/doi/full/10.1080/10286020600727665 DB - PRIME DP - Unbound Medicine ER -