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Prospective study of alcohol consumption and the risk of primary open-angle glaucoma.
Ophthalmic Epidemiol 2007 May-Jun; 14(3):141-7OE

Abstract

PURPOSE

Alcohol intake reduces intraocular pressure, a risk factor for primary open-angle glaucoma (POAG). We investigated whether alcohol consumption is associated with a reduced risk of POAG.

METHODS

We followed female nurses from 1980 and male health professionals from 1986 to 2002. Eligible participants were 40+ years old, did not have POAG, and reported receiving eye examinations during follow-up. Information on alcohol consumption, potential confounders and POAG diagnoses were updated by using biennial questionnaires. We identified 856 self-reported POAG cases that were confirmed with medical record review. Cohort-specific and pooled analyses across cohorts were conducted to calculate multivariable rate ratios (RR) of POAG.

RESULTS

Alcohol consumption<30 g/day did not influence POAG risk: compared with non-drinkers, the pooled RRs were 0.99 (95% Confidence Interval [CI]: 0.83-1.19) for drinking<10 g/day, 0.96 (95% CI: 0.76-1.22) for 10-19 g/day, and 0.95 (95% CI: 0.68-1.33) for 20-29 g/day. Although there were suggestive inverse associations with drinking>30 g/day (RR=0.71), this was not significant (95% CI: 0.49-1.04), and no significant linear associations were detected. Risks of POAG did not differ by type of alcoholic beverage consumed. To evaluate the potential for detection bias, we controlled for additional factors, such as frequency of eye exams, but results were similar.

CONCLUSION

In this large prospective study of men and women, alcohol consumption did not influence the risk of POAG.

Authors+Show Affiliations

Channing Laboratory, Department of Medicine, Harvard Medical School and Brigham & Women's Hospital, Boston, Massachusetts 02115, USA. nhjhk@channing.harvard.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

17613849

Citation

Kang, Jae H., et al. "Prospective Study of Alcohol Consumption and the Risk of Primary Open-angle Glaucoma." Ophthalmic Epidemiology, vol. 14, no. 3, 2007, pp. 141-7.
Kang JH, Willett WC, Rosner BA, et al. Prospective study of alcohol consumption and the risk of primary open-angle glaucoma. Ophthalmic Epidemiol. 2007;14(3):141-7.
Kang, J. H., Willett, W. C., Rosner, B. A., Hankinson, S. E., & Pasquale, L. R. (2007). Prospective study of alcohol consumption and the risk of primary open-angle glaucoma. Ophthalmic Epidemiology, 14(3), pp. 141-7.
Kang JH, et al. Prospective Study of Alcohol Consumption and the Risk of Primary Open-angle Glaucoma. Ophthalmic Epidemiol. 2007;14(3):141-7. PubMed PMID: 17613849.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prospective study of alcohol consumption and the risk of primary open-angle glaucoma. AU - Kang,Jae H, AU - Willett,Walter C, AU - Rosner,Bernard A, AU - Hankinson,Susan E, AU - Pasquale,Louis R, PY - 2007/7/7/pubmed PY - 2007/8/22/medline PY - 2007/7/7/entrez SP - 141 EP - 7 JF - Ophthalmic epidemiology JO - Ophthalmic Epidemiol VL - 14 IS - 3 N2 - PURPOSE: Alcohol intake reduces intraocular pressure, a risk factor for primary open-angle glaucoma (POAG). We investigated whether alcohol consumption is associated with a reduced risk of POAG. METHODS: We followed female nurses from 1980 and male health professionals from 1986 to 2002. Eligible participants were 40+ years old, did not have POAG, and reported receiving eye examinations during follow-up. Information on alcohol consumption, potential confounders and POAG diagnoses were updated by using biennial questionnaires. We identified 856 self-reported POAG cases that were confirmed with medical record review. Cohort-specific and pooled analyses across cohorts were conducted to calculate multivariable rate ratios (RR) of POAG. RESULTS: Alcohol consumption<30 g/day did not influence POAG risk: compared with non-drinkers, the pooled RRs were 0.99 (95% Confidence Interval [CI]: 0.83-1.19) for drinking<10 g/day, 0.96 (95% CI: 0.76-1.22) for 10-19 g/day, and 0.95 (95% CI: 0.68-1.33) for 20-29 g/day. Although there were suggestive inverse associations with drinking>30 g/day (RR=0.71), this was not significant (95% CI: 0.49-1.04), and no significant linear associations were detected. Risks of POAG did not differ by type of alcoholic beverage consumed. To evaluate the potential for detection bias, we controlled for additional factors, such as frequency of eye exams, but results were similar. CONCLUSION: In this large prospective study of men and women, alcohol consumption did not influence the risk of POAG. SN - 0928-6586 UR - https://www.unboundmedicine.com/medline/citation/17613849/Prospective_study_of_alcohol_consumption_and_the_risk_of_primary_open_angle_glaucoma_ L2 - http://www.tandfonline.com/doi/full/10.1080/09286580601187963 DB - PRIME DP - Unbound Medicine ER -