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Reappraisal of a consecutive autopsy series of patients with primary degenerative dementia: Lewy-related pathology.
APMIS. 2007 Jul; 115(7):820-7.A

Abstract

Dementia with Lewy bodies (DLB) is a common but underdiagnosed dementing disorder. Its criteria were defined in 1996, and revised in 2005. DLB is characterised neuropathologically by widely distributed cortical Lewy bodies (LBs), usually associated with Alzheimer-type pathology. We have re-evaluated the neuropathology of 55 autopsied patients with clinically diagnosed primary degenerative dementia to determine the frequency of DLB in this cohort, which was originally examined when neither the entity of DLB nor its diagnostic criteria had been defined. We also evaluated how discovery of a new entity affects previous diagnoses. Of the 55 brains, 16 (29%) contained LBs. All 16 originally had a neuropathological diagnosis of Alzheimer's disease (AD). 11 (20%) fulfilled the neuropathological criteria for DLB. Three patients had AD with LBs in the brain stem only, and two patients had LBs in the limbic cortex only. Because the criteria and reliable markers for DLB were not available at the time of the autopsies, the diagnosis of DLB had not been possible. The common co-occurrence of AD-type pathology in DLB makes the clinical diagnosis of DLB problematic even today. This study also raises the question of the relative significances of Lewy-related and AD-type pathologies to the development of dementia.

Authors+Show Affiliations

Department of Pathology, University of Helsinki, Helsinki, Finland. minna.oinas@helsinki.fiNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17614849

Citation

Oinas, M, et al. "Reappraisal of a Consecutive Autopsy Series of Patients With Primary Degenerative Dementia: Lewy-related Pathology." APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica, vol. 115, no. 7, 2007, pp. 820-7.
Oinas M, Sulkava R, Polvikoski T, et al. Reappraisal of a consecutive autopsy series of patients with primary degenerative dementia: Lewy-related pathology. APMIS. 2007;115(7):820-7.
Oinas, M., Sulkava, R., Polvikoski, T., Kalimo, H., & Paetau, A. (2007). Reappraisal of a consecutive autopsy series of patients with primary degenerative dementia: Lewy-related pathology. APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica, 115(7), 820-7.
Oinas M, et al. Reappraisal of a Consecutive Autopsy Series of Patients With Primary Degenerative Dementia: Lewy-related Pathology. APMIS. 2007;115(7):820-7. PubMed PMID: 17614849.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Reappraisal of a consecutive autopsy series of patients with primary degenerative dementia: Lewy-related pathology. AU - Oinas,M, AU - Sulkava,R, AU - Polvikoski,T, AU - Kalimo,H, AU - Paetau,A, PY - 2007/7/7/pubmed PY - 2007/9/6/medline PY - 2007/7/7/entrez SP - 820 EP - 7 JF - APMIS : acta pathologica, microbiologica, et immunologica Scandinavica JO - APMIS VL - 115 IS - 7 N2 - Dementia with Lewy bodies (DLB) is a common but underdiagnosed dementing disorder. Its criteria were defined in 1996, and revised in 2005. DLB is characterised neuropathologically by widely distributed cortical Lewy bodies (LBs), usually associated with Alzheimer-type pathology. We have re-evaluated the neuropathology of 55 autopsied patients with clinically diagnosed primary degenerative dementia to determine the frequency of DLB in this cohort, which was originally examined when neither the entity of DLB nor its diagnostic criteria had been defined. We also evaluated how discovery of a new entity affects previous diagnoses. Of the 55 brains, 16 (29%) contained LBs. All 16 originally had a neuropathological diagnosis of Alzheimer's disease (AD). 11 (20%) fulfilled the neuropathological criteria for DLB. Three patients had AD with LBs in the brain stem only, and two patients had LBs in the limbic cortex only. Because the criteria and reliable markers for DLB were not available at the time of the autopsies, the diagnosis of DLB had not been possible. The common co-occurrence of AD-type pathology in DLB makes the clinical diagnosis of DLB problematic even today. This study also raises the question of the relative significances of Lewy-related and AD-type pathologies to the development of dementia. SN - 0903-4641 UR - https://www.unboundmedicine.com/medline/citation/17614849/Reappraisal_of_a_consecutive_autopsy_series_of_patients_with_primary_degenerative_dementia:_Lewy_related_pathology_ L2 - https://doi.org/10.1111/j.1600-0463.2007.apm_521.x DB - PRIME DP - Unbound Medicine ER -