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Analgesic and anti-inflammatory activities of aqueous extract from Glycine tomentella root in mice.
J Ethnopharmacol. 2007 Aug 15; 113(1):142-8.JE

Abstract

In the present study, we have investigated the analgesic effect of the aqueous extract of the root of Glycine tomentella (AGT) using models of acetic acid-induced writhing response and formalin test, the anti-inflammatory effect of AGT using model of lambda-carrageenan-induced paw edema. In order to investigate the anti-inflammatory mechanism of AGT, we have detected the activities of glutathione peroxidase (GPx) and glutathione reductase (GRx) in the liver and the levels of malondialdehyde (MDA) and NO in the edema paw. In the analgesic test, AGT (0.5 and 1.0 g/kg) decreased the acetic acid-induced writhing response and the licking time on the late phase in the formalin test. In the anti-inflammatory test, AGT (0.5 and 1.0 g/kg) decreased the paw edema at the third, fourth, fifth and sixth hour after lambda-carrageenan administration, and increased the activities of SOD, GPx and GRx in the liver tissue and decreased the MDA level in the edema paw at the third hour after lambda-carrageenan injection. However, AGT could not affect the NO level which induced by lambda-carrageenan. These results suggested that AGT possessed analgesic and anti-inflammatory effects. The anti-inflammatory mechanism of AGT might be related to the decrease in the level of MDA in the edema paw via increasing the activities of SOD, GPx and GRx in the liver.

Authors+Show Affiliations

Graduate Institute of Chinese Pharmaceutical Sciences, College of Pharmacy, China Medical University, 91 Hsueh-Shih Road, Taichung, Taiwan, ROC.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17616291

Citation

Lu, Tsung-Chun, et al. "Analgesic and Anti-inflammatory Activities of Aqueous Extract From Glycine Tomentella Root in Mice." Journal of Ethnopharmacology, vol. 113, no. 1, 2007, pp. 142-8.
Lu TC, Ko YZ, Huang HW, et al. Analgesic and anti-inflammatory activities of aqueous extract from Glycine tomentella root in mice. J Ethnopharmacol. 2007;113(1):142-8.
Lu, T. C., Ko, Y. Z., Huang, H. W., Hung, Y. C., Lin, Y. C., & Peng, W. H. (2007). Analgesic and anti-inflammatory activities of aqueous extract from Glycine tomentella root in mice. Journal of Ethnopharmacology, 113(1), 142-8.
Lu TC, et al. Analgesic and Anti-inflammatory Activities of Aqueous Extract From Glycine Tomentella Root in Mice. J Ethnopharmacol. 2007 Aug 15;113(1):142-8. PubMed PMID: 17616291.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Analgesic and anti-inflammatory activities of aqueous extract from Glycine tomentella root in mice. AU - Lu,Tsung-Chun, AU - Ko,Yu-Zen, AU - Huang,Hsin-Wei, AU - Hung,Ying-Chun, AU - Lin,Ying-Chih, AU - Peng,Wen-Huang, Y1 - 2007/05/31/ PY - 2007/02/27/received PY - 2007/04/25/revised PY - 2007/05/25/accepted PY - 2007/7/10/pubmed PY - 2007/11/14/medline PY - 2007/7/10/entrez SP - 142 EP - 8 JF - Journal of ethnopharmacology JO - J Ethnopharmacol VL - 113 IS - 1 N2 - In the present study, we have investigated the analgesic effect of the aqueous extract of the root of Glycine tomentella (AGT) using models of acetic acid-induced writhing response and formalin test, the anti-inflammatory effect of AGT using model of lambda-carrageenan-induced paw edema. In order to investigate the anti-inflammatory mechanism of AGT, we have detected the activities of glutathione peroxidase (GPx) and glutathione reductase (GRx) in the liver and the levels of malondialdehyde (MDA) and NO in the edema paw. In the analgesic test, AGT (0.5 and 1.0 g/kg) decreased the acetic acid-induced writhing response and the licking time on the late phase in the formalin test. In the anti-inflammatory test, AGT (0.5 and 1.0 g/kg) decreased the paw edema at the third, fourth, fifth and sixth hour after lambda-carrageenan administration, and increased the activities of SOD, GPx and GRx in the liver tissue and decreased the MDA level in the edema paw at the third hour after lambda-carrageenan injection. However, AGT could not affect the NO level which induced by lambda-carrageenan. These results suggested that AGT possessed analgesic and anti-inflammatory effects. The anti-inflammatory mechanism of AGT might be related to the decrease in the level of MDA in the edema paw via increasing the activities of SOD, GPx and GRx in the liver. SN - 0378-8741 UR - https://www.unboundmedicine.com/medline/citation/17616291/Analgesic_and_anti_inflammatory_activities_of_aqueous_extract_from_Glycine_tomentella_root_in_mice_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-8741(07)00270-X DB - PRIME DP - Unbound Medicine ER -