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Thyroid hormones changes in infants and children with metabolic acidosis.
J Endocrinol Invest. 1991 Oct; 14(9):723-6.JE

Abstract

The influence of the acidotic state on the thyroxine (T4) peripheral metabolism was studied in two different forms of metabolic acidosis, ie infantile diarrhea and diabetic ketoacidosis. The serum concentrations of T4, free T4 (FT4), triiodothyronine (T3), reverse T3 (rT3), thyrotropin (TSH) and thyroxine-binding globulin (TBG) were measured and compared to healthy control groups. Lower T4 and T3 and higher rT3 serum concentrations were found in both tested groups of patients in relation to the control groups. In infants with severe metabolic acidosis FT4 values were lower than those observed in the control group. In addition, serum TBG levels were lower in diabetic patients as compared to control subjects. Despite the reduced serum T3 and T4 concentrations in both groups of patients, TSH concentrations, were within the normal range. Therefore, we concluded that acidosis caused either by diarrhea (not so far described) or by diabetes mellitus (well documented up to now) affects the thyroid hormones metabolism in a similar way, at least as far as the thyroid hormones blood levels are concerned.

Authors+Show Affiliations

Department of Pediatrics, Medical Faculty, University of Tuzla, Yugoslavia.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

1761806

Citation

Tahirović, H F.. "Thyroid Hormones Changes in Infants and Children With Metabolic Acidosis." Journal of Endocrinological Investigation, vol. 14, no. 9, 1991, pp. 723-6.
Tahirović HF. Thyroid hormones changes in infants and children with metabolic acidosis. J Endocrinol Invest. 1991;14(9):723-6.
Tahirović, H. F. (1991). Thyroid hormones changes in infants and children with metabolic acidosis. Journal of Endocrinological Investigation, 14(9), 723-6.
Tahirović HF. Thyroid Hormones Changes in Infants and Children With Metabolic Acidosis. J Endocrinol Invest. 1991;14(9):723-6. PubMed PMID: 1761806.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Thyroid hormones changes in infants and children with metabolic acidosis. A1 - Tahirović,H F, PY - 1991/10/1/pubmed PY - 1991/10/1/medline PY - 1991/10/1/entrez SP - 723 EP - 6 JF - Journal of endocrinological investigation JO - J. Endocrinol. Invest. VL - 14 IS - 9 N2 - The influence of the acidotic state on the thyroxine (T4) peripheral metabolism was studied in two different forms of metabolic acidosis, ie infantile diarrhea and diabetic ketoacidosis. The serum concentrations of T4, free T4 (FT4), triiodothyronine (T3), reverse T3 (rT3), thyrotropin (TSH) and thyroxine-binding globulin (TBG) were measured and compared to healthy control groups. Lower T4 and T3 and higher rT3 serum concentrations were found in both tested groups of patients in relation to the control groups. In infants with severe metabolic acidosis FT4 values were lower than those observed in the control group. In addition, serum TBG levels were lower in diabetic patients as compared to control subjects. Despite the reduced serum T3 and T4 concentrations in both groups of patients, TSH concentrations, were within the normal range. Therefore, we concluded that acidosis caused either by diarrhea (not so far described) or by diabetes mellitus (well documented up to now) affects the thyroid hormones metabolism in a similar way, at least as far as the thyroid hormones blood levels are concerned. SN - 0391-4097 UR - https://www.unboundmedicine.com/medline/citation/1761806/Thyroid_hormones_changes_in_infants_and_children_with_metabolic_acidosis_ L2 - https://link.springer.com/article/10.1007/BF03347903 DB - PRIME DP - Unbound Medicine ER -