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Traumatic brain injury and Alzheimer's disease: a review.
Prog Brain Res 2007; 161:303-16PB

Abstract

In an effort to identify the factors that are involved in the pathogenesis of Alzheimer's disease (AD), epidemiological studies have featured prominently in contemporary research. Of those epidemiological factors, accumulating evidence implicates traumatic brain injury (TBI) as a possible predisposing factor in AD development. Exactly how TBI triggers the neurodegenerative cascade of events in AD remains controversial. There has been extensive research directed towards understanding the potential relationship between TBI and AD and the putative influence that apolipoprotein E (APOE) genotype has on this relationship. The aim of the current paper is to provide a critical summary of the experimental and human studies regarding the association between TBI, AD and APOE genotype. It will be shown that despite significant discrepancies in the literature, there still appears to be an increasing trend to support the hypothesis that TBI is a potential risk factor for AD. Furthermore, although it is known that APOE genotype plays an important role in AD, its link to a deleterious outcome following TBI remains inconclusive and ambiguous.

Authors+Show Affiliations

Discipline of Pathology, University of Adelaide, Centre for Neurological Diseases, The Hanson Institute, Adelaide, Australia. corinna.vandenheuvel@adelaide.edu.auNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

17618986

Citation

Van Den Heuvel, Corinna, et al. "Traumatic Brain Injury and Alzheimer's Disease: a Review." Progress in Brain Research, vol. 161, 2007, pp. 303-16.
Van Den Heuvel C, Thornton E, Vink R. Traumatic brain injury and Alzheimer's disease: a review. Prog Brain Res. 2007;161:303-16.
Van Den Heuvel, C., Thornton, E., & Vink, R. (2007). Traumatic brain injury and Alzheimer's disease: a review. Progress in Brain Research, 161, pp. 303-16.
Van Den Heuvel C, Thornton E, Vink R. Traumatic Brain Injury and Alzheimer's Disease: a Review. Prog Brain Res. 2007;161:303-16. PubMed PMID: 17618986.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Traumatic brain injury and Alzheimer's disease: a review. AU - Van Den Heuvel,Corinna, AU - Thornton,Emma, AU - Vink,Robert, PY - 2007/7/10/pubmed PY - 2007/10/27/medline PY - 2007/7/10/entrez SP - 303 EP - 16 JF - Progress in brain research JO - Prog. Brain Res. VL - 161 N2 - In an effort to identify the factors that are involved in the pathogenesis of Alzheimer's disease (AD), epidemiological studies have featured prominently in contemporary research. Of those epidemiological factors, accumulating evidence implicates traumatic brain injury (TBI) as a possible predisposing factor in AD development. Exactly how TBI triggers the neurodegenerative cascade of events in AD remains controversial. There has been extensive research directed towards understanding the potential relationship between TBI and AD and the putative influence that apolipoprotein E (APOE) genotype has on this relationship. The aim of the current paper is to provide a critical summary of the experimental and human studies regarding the association between TBI, AD and APOE genotype. It will be shown that despite significant discrepancies in the literature, there still appears to be an increasing trend to support the hypothesis that TBI is a potential risk factor for AD. Furthermore, although it is known that APOE genotype plays an important role in AD, its link to a deleterious outcome following TBI remains inconclusive and ambiguous. SN - 0079-6123 UR - https://www.unboundmedicine.com/medline/citation/17618986/Traumatic_brain_injury_and_Alzheimer's_disease:_a_review_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0079-6123(06)61021-2 DB - PRIME DP - Unbound Medicine ER -