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[Detection of gamma-hydroxybutyrate (GHB) in beverages].
Fa Yi Xue Za Zhi. 2007 Apr; 23(2):120-2, 129.FY

Abstract

OBJECTIVE

To establish an analytical method for the determination of GHB in beverages using GC/MS and LC/MS/MS.

METHODS

After beverage samples with GHB-d6 as the internal standard were extracted with ethyl acetate, then the extracts were derivatized with N,O-bis(trimethylsilyl)trifluoroacetamide (BSTFA), at last the derivateized extracts analyzed by gas chromatography- mass spectrometry. After beverage samples with GHB-d6 as the internal standard were diluted by mobile phase then directly analyzed by LC/MS/MS. Results The limit of detection was 0.2 microg/mL and both relative standard deviations for between-day and within-day assays were < 8.54% in GC/MS. The limit of detection was 2 microg/mL and both relative standard deviations for between-day and within-day assays were <8.62% in LC/MS/MS. Conclusion These methods of qualitative and quantitative analysis were found to be sensitive, accurate, rapid and suitable for the forensic toxicology to test of GHB in real cases.

Authors+Show Affiliations

Institute of Forensic Sciences, Ministry of Justice, P.R. China, Shanghai 200063, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article
Research Support, Non-U.S. Gov't

Language

chi

PubMed ID

17619459

Citation

Liu, Wei, et al. "[Detection of Gamma-hydroxybutyrate (GHB) in Beverages]." Fa Yi Xue Za Zhi, vol. 23, no. 2, 2007, pp. 120-2, 129.
Liu W, Shen M, Xiang P, et al. [Detection of gamma-hydroxybutyrate (GHB) in beverages]. Fa Yi Xue Za Zhi. 2007;23(2):120-2, 129.
Liu, W., Shen, M., Xiang, P., Bu, J., & Wu, H. J. (2007). [Detection of gamma-hydroxybutyrate (GHB) in beverages]. Fa Yi Xue Za Zhi, 23(2), 120-2, 129.
Liu W, et al. [Detection of Gamma-hydroxybutyrate (GHB) in Beverages]. Fa Yi Xue Za Zhi. 2007;23(2):120-2, 129. PubMed PMID: 17619459.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Detection of gamma-hydroxybutyrate (GHB) in beverages]. AU - Liu,Wei, AU - Shen,Min, AU - Xiang,Ping, AU - Bu,Jun, AU - Wu,He-Jian, PY - 2007/7/11/pubmed PY - 2010/4/7/medline PY - 2007/7/11/entrez SP - 120-2, 129 JF - Fa yi xue za zhi JO - Fa Yi Xue Za Zhi VL - 23 IS - 2 N2 - OBJECTIVE: To establish an analytical method for the determination of GHB in beverages using GC/MS and LC/MS/MS. METHODS: After beverage samples with GHB-d6 as the internal standard were extracted with ethyl acetate, then the extracts were derivatized with N,O-bis(trimethylsilyl)trifluoroacetamide (BSTFA), at last the derivateized extracts analyzed by gas chromatography- mass spectrometry. After beverage samples with GHB-d6 as the internal standard were diluted by mobile phase then directly analyzed by LC/MS/MS. Results The limit of detection was 0.2 microg/mL and both relative standard deviations for between-day and within-day assays were < 8.54% in GC/MS. The limit of detection was 2 microg/mL and both relative standard deviations for between-day and within-day assays were <8.62% in LC/MS/MS. Conclusion These methods of qualitative and quantitative analysis were found to be sensitive, accurate, rapid and suitable for the forensic toxicology to test of GHB in real cases. SN - 1004-5619 UR - https://www.unboundmedicine.com/medline/citation/17619459/[Detection_of_gamma_hydroxybutyrate__GHB__in_beverages]_ L2 - https://medlineplus.gov/clubdrugs.html DB - PRIME DP - Unbound Medicine ER -