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Damage to lipids, proteins, DNA, and RNA in mild cognitive impairment.
Arch Neurol. 2007 Jul; 64(7):954-6.AN

Abstract

Free radical-mediated oxidative damage is thought to play a role in the pathogenesis of Alzheimer disease. Previous studies have shown oxidative damage to lipids, proteins, DNA, and RNA in multiple brain regions in late-stage Alzheimer disease. Recent studies on patients with amnestic mild cognitive impairment who have undergone autopsy have shown increased lipid peroxidation as well as protein, DNA, and RNA oxidation in multiple brain regions. These studies establish oxidative damage as an early event in the pathogenesis of Alzheimer disease that can serve as a therapeutic target to slow the progression or perhaps the onset of the disease.

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Authors+Show Affiliations

Markesbery WR
Department of Neurology, University of Kentucky, Lexington, KY 40536-0230, USA. wmark0@email.uky.edu
Lovell MA
No affiliation info available

MeSH

Alzheimer DiseaseAntioxidantsBrainCognition DisordersDNA DamageDisease ProgressionHumansLipid PeroxidationNerve Tissue ProteinsNucleic AcidsOxidative Stress

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Review

Language

eng

PubMed ID

17620484

Citation

Markesbery, William R., and Mark A. Lovell. "Damage to Lipids, Proteins, DNA, and RNA in Mild Cognitive Impairment." Archives of Neurology, vol. 64, no. 7, 2007, pp. 954-6.
Markesbery WR, Lovell MA. Damage to lipids, proteins, DNA, and RNA in mild cognitive impairment. Arch Neurol. 2007;64(7):954-6.
Markesbery, W. R., & Lovell, M. A. (2007). Damage to lipids, proteins, DNA, and RNA in mild cognitive impairment. Archives of Neurology, 64(7), 954-6.
Markesbery WR, Lovell MA. Damage to Lipids, Proteins, DNA, and RNA in Mild Cognitive Impairment. Arch Neurol. 2007;64(7):954-6. PubMed PMID: 17620484.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Damage to lipids, proteins, DNA, and RNA in mild cognitive impairment. AU - Markesbery,William R, AU - Lovell,Mark A, PY - 2007/7/11/pubmed PY - 2007/9/1/medline PY - 2007/7/11/entrez SP - 954 EP - 6 JF - Archives of neurology JO - Arch Neurol VL - 64 IS - 7 N2 - Free radical-mediated oxidative damage is thought to play a role in the pathogenesis of Alzheimer disease. Previous studies have shown oxidative damage to lipids, proteins, DNA, and RNA in multiple brain regions in late-stage Alzheimer disease. Recent studies on patients with amnestic mild cognitive impairment who have undergone autopsy have shown increased lipid peroxidation as well as protein, DNA, and RNA oxidation in multiple brain regions. These studies establish oxidative damage as an early event in the pathogenesis of Alzheimer disease that can serve as a therapeutic target to slow the progression or perhaps the onset of the disease. SN - 0003-9942 UR - https://www.unboundmedicine.com/medline/citation/17620484/Damage_to_lipids_proteins_DNA_and_RNA_in_mild_cognitive_impairment_ L2 - https://jamanetwork.com/journals/jamaneurology/fullarticle/10.1001/archneur.64.7.954 DB - PRIME DP - Unbound Medicine ER -