Damage to lipids, proteins, DNA, and RNA in mild cognitive impairment.Arch Neurol. 2007 Jul; 64(7):954-6.AN
Abstract
Free radical-mediated oxidative damage is thought to play a role in the pathogenesis of Alzheimer disease. Previous studies have shown oxidative damage to lipids, proteins, DNA, and RNA in multiple brain regions in late-stage Alzheimer disease. Recent studies on patients with amnestic mild cognitive impairment who have undergone autopsy have shown increased lipid peroxidation as well as protein, DNA, and RNA oxidation in multiple brain regions. These studies establish oxidative damage as an early event in the pathogenesis of Alzheimer disease that can serve as a therapeutic target to slow the progression or perhaps the onset of the disease.
Links
MeSH
Pub Type(s)
Journal Article
Research Support, N.I.H., Extramural
Review
Language
eng
PubMed ID
17620484
Citation
Markesbery, William R., and Mark A. Lovell. "Damage to Lipids, Proteins, DNA, and RNA in Mild Cognitive Impairment." Archives of Neurology, vol. 64, no. 7, 2007, pp. 954-6.
Markesbery WR, Lovell MA. Damage to lipids, proteins, DNA, and RNA in mild cognitive impairment. Arch Neurol. 2007;64(7):954-6.
Markesbery, W. R., & Lovell, M. A. (2007). Damage to lipids, proteins, DNA, and RNA in mild cognitive impairment. Archives of Neurology, 64(7), 954-6.
Markesbery WR, Lovell MA. Damage to Lipids, Proteins, DNA, and RNA in Mild Cognitive Impairment. Arch Neurol. 2007;64(7):954-6. PubMed PMID: 17620484.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR
T1 - Damage to lipids, proteins, DNA, and RNA in mild cognitive impairment.
AU - Markesbery,William R,
AU - Lovell,Mark A,
PY - 2007/7/11/pubmed
PY - 2007/9/1/medline
PY - 2007/7/11/entrez
SP - 954
EP - 6
JF - Archives of neurology
JO - Arch Neurol
VL - 64
IS - 7
N2 - Free radical-mediated oxidative damage is thought to play a role in the pathogenesis of Alzheimer disease. Previous studies have shown oxidative damage to lipids, proteins, DNA, and RNA in multiple brain regions in late-stage Alzheimer disease. Recent studies on patients with amnestic mild cognitive impairment who have undergone autopsy have shown increased lipid peroxidation as well as protein, DNA, and RNA oxidation in multiple brain regions. These studies establish oxidative damage as an early event in the pathogenesis of Alzheimer disease that can serve as a therapeutic target to slow the progression or perhaps the onset of the disease.
SN - 0003-9942
UR - https://www.unboundmedicine.com/medline/citation/17620484/Damage_to_lipids_proteins_DNA_and_RNA_in_mild_cognitive_impairment_
L2 - https://jamanetwork.com/journals/jamaneurology/fullarticle/10.1001/archneur.64.7.954
DB - PRIME
DP - Unbound Medicine
ER -