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Damage to lipids, proteins, DNA, and RNA in mild cognitive impairment.
Arch Neurol 2007; 64(7):954-6AN

Abstract

Free radical-mediated oxidative damage is thought to play a role in the pathogenesis of Alzheimer disease. Previous studies have shown oxidative damage to lipids, proteins, DNA, and RNA in multiple brain regions in late-stage Alzheimer disease. Recent studies on patients with amnestic mild cognitive impairment who have undergone autopsy have shown increased lipid peroxidation as well as protein, DNA, and RNA oxidation in multiple brain regions. These studies establish oxidative damage as an early event in the pathogenesis of Alzheimer disease that can serve as a therapeutic target to slow the progression or perhaps the onset of the disease.

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    Authors+Show Affiliations

    Markesbery WR
    Department of Neurology, University of Kentucky, Lexington, KY 40536-0230, USA. wmark0@email.uky.edu
    Lovell MA
    No affiliation info available

    MeSH

    Alzheimer DiseaseAntioxidantsBrainCognition DisordersDNA DamageDisease ProgressionHumansLipid PeroxidationNerve Tissue ProteinsNucleic AcidsOxidative Stress

    Pub Type(s)

    Journal Article
    Research Support, N.I.H., Extramural
    Review

    Language

    eng

    PubMed ID

    17620484

    Citation

    Markesbery, William R., and Mark A. Lovell. "Damage to Lipids, Proteins, DNA, and RNA in Mild Cognitive Impairment." Archives of Neurology, vol. 64, no. 7, 2007, pp. 954-6.
    Markesbery WR, Lovell MA. Damage to lipids, proteins, DNA, and RNA in mild cognitive impairment. Arch Neurol. 2007;64(7):954-6.
    Markesbery, W. R., & Lovell, M. A. (2007). Damage to lipids, proteins, DNA, and RNA in mild cognitive impairment. Archives of Neurology, 64(7), pp. 954-6.
    Markesbery WR, Lovell MA. Damage to Lipids, Proteins, DNA, and RNA in Mild Cognitive Impairment. Arch Neurol. 2007;64(7):954-6. PubMed PMID: 17620484.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Damage to lipids, proteins, DNA, and RNA in mild cognitive impairment. AU - Markesbery,William R, AU - Lovell,Mark A, PY - 2007/7/11/pubmed PY - 2007/9/1/medline PY - 2007/7/11/entrez SP - 954 EP - 6 JF - Archives of neurology JO - Arch. Neurol. VL - 64 IS - 7 N2 - Free radical-mediated oxidative damage is thought to play a role in the pathogenesis of Alzheimer disease. Previous studies have shown oxidative damage to lipids, proteins, DNA, and RNA in multiple brain regions in late-stage Alzheimer disease. Recent studies on patients with amnestic mild cognitive impairment who have undergone autopsy have shown increased lipid peroxidation as well as protein, DNA, and RNA oxidation in multiple brain regions. These studies establish oxidative damage as an early event in the pathogenesis of Alzheimer disease that can serve as a therapeutic target to slow the progression or perhaps the onset of the disease. SN - 0003-9942 UR - https://www.unboundmedicine.com/medline/citation/17620484/Damage_to_lipids_proteins_DNA_and_RNA_in_mild_cognitive_impairment_ L2 - https://jamanetwork.com/journals/jamaneurology/fullarticle/10.1001/archneur.64.7.954 DB - PRIME DP - Unbound Medicine ER -